Neuropharmacology. 2012 Jul 11.
puna
Psychology Department, University of Wisconsin, 1202 W. Johnson St., Madison, WI 53706, ISA.
lē faʻatino
O vailaʻau na faʻaaoga e togafitia ai le faʻafitauli o le le atoatoa lelei o le toto (ADHD) faʻaleleia atili ai le faʻamuamua (PFC) -o le faʻalagolago i le mafaufau. Ole toʻatele o togafitiga e fesoʻotaʻi ma ADHD, e avea ma norepinephrine (NE) ma le dopamine (DA) e taofia ai le toe taofia (psychostimulants) poʻo ni tagata e filifili e toe faʻafouina NE (SNRIs). Nisi ituaiga benztropine analogs galue pei sili ona filifilia DA reuptake taofiofia ao le lava le faʻamalosia gaioiga, ma faʻasuaʻava gafatia, o psychostimulants. Ina ia iloiloina le ono faʻaaogaina o nei mea tuʻufaʻatasi i le togafitia o le ADHD, na matou suʻesuʻeina ai aʻafiaga o le ituaiga lelei o le benztropine, AHN 2-005, i le faʻatinoina o isumu i le PFC-faʻatuai tuai-fesuiaʻi galuega o spatial galue manatuaina. Tutusa i le mea na vaʻaia ma vailaʻau uma ua faʻamaonia nei mo ADHD, AHN 2-005 fualaʻau-faʻalagolago atili faʻaleleia atili gaioiga i lenei galuega. Togafitiga-talafeagai tui o psychostimulants ma SNRIs siitia NE ma DA sili i le PFC. E ui lava i le filifilia o lenei mea tuʻufaʻatasia mo le felauaiga a le DA, o suʻesuʻega faʻaopopo microdialysis na faʻaalia ai o le aʻoga e faʻalauteleina le fualaʻau o le AHN 2-005 na le maua le locomotor activating effects faʻateleina extracellular maualuga o uma DA ma NE i le PFC. O le AHN 2-005 na faʻatupuina le tele o le faʻateleina o extracellular DA i totonu o le tumutumu o le tumutumu, e ui lava o le maualuga o lenei mea sa i lalo ifo o le vaʻaia ma le afi o loʻo faʻatupuina inumaga o psychostimulants. I se tuʻufaʻatasiga, o nei maitauga e atagia mai ai o le benztropine analogs atonu e aoga tele i le togafitia o ADHD poʻo isi faʻalavelave e fesoʻotaʻi ma le PFC faʻaletonu. O nei suʻesuʻega maua ai se malosi mafuaʻaga mo lumanaʻi suʻesuʻega taulaʻi i neural auala e fesoasoani ai i le mafaufau-faʻalauteleina gaioiga ma le ono aoga falemaʻi o le AHN 2-005 ma fesoʻotaʻiga faʻatasi. Lenei tusitusiga o se vaega o le Faʻapitoa Faʻailogaina faʻaulutalaina 'Cognitive Enhancers'.
Puletaofia © 2012 Elsevier Ltd. Faʻasao aia tatau uma.
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