Faʻamatalaga a le YBOP: O le maualalo o le aofaʻi o dopamine taliaina (D2) e fesoʻotaʻi ma le faʻafitauli o le popolevale lautele. Tele o tagata mamafa porn faʻaaogaina lagona i agafesootai popolega. O nisi lipotia le faʻateleina o popolega lautele pe a maeʻa se porn binge. Mo le tele o popolega e faʻaleleia atili i le le toe taumamafa - mo sina taimi puʻupuʻu, o isi mo se taimi umi. Manatua o le sili atu faʻaosofia (vaisu) e tau atu i le tuʻuina i lalo o le dopamine D2 taliaina. Faʻaaliga: Ou te le o fai atu o le porn mafua ai uma mataupu o le SAD.
Am J Psychiatry. 2000 Mar;157(3):457-9.
Schneier FR, Liebowitz MR, Abi-Dargham A, Zea-Ponce Y, Lin SH, Laruelle M. Clinical Disorders Clinic ma le Vaega o Ata Mataga, New York State Institute of Psychiatric, New York 10032, USA.
MANULAUTI: O lenei suʻesuʻega e faʻatusatusaina ai le faʻamalamalamaina o le dopamine D (2) e mafai ona gafatia faʻamaʻi i tagata gasegase i le telefoni faʻafesootai ma le faʻatusatusaina o mataupu.
METHOD: Dopamine D (2) na mafai ona tuʻuina atu i le 10 faʻataʻitaʻiga faʻamaonia ma le televise telefoni faʻasalalau ma le leai o se soifuaga o le psychiatric comorbidity ma 10 faʻataʻitaʻiga lelei faʻatusatusa e fetaui ma le matua ma le va. Na mafai ona fuaina le malosi o le fusifusia i le vaega e ala i le faʻaaogaina o faʻamatalaga komepiuta e faʻaogaina ai le photon e tasi ma le faʻaauau pea o le radio (DVNUMX) I le iodobenzamide (2) i le iodobenzamide ([(123) I] IBZM).
TULAFONO: O le aʻafiaga o le senitise D (2) e mafai ona tuʻufaʻatasia le gasegase na sili ona maualalo i mataupu ma feʻau faʻapitoa nai lo mataupu faʻatusatusa. I totonu o le vaega o fefaatauaiga lautele, sa i ai se tuufaatasiga le mafaatusalia o le mafai ona fusia ma le Liebowitz Social Social Asset Scale.
FAAIUGA: E mafai ona fesoʻotaʻi le televise fesoʻotaʻi vavalalata ma le maulalo o [(123) I] IBZM i le D (2) o loʻo talia i le striatum.
INTRO
O le siʻomaga lautele o phobia faʻaalia, e faʻaalia e le fefe ma / poʻo le aloese mai le tele o tulaga faʻalapotopotoga, e masani ona fai (1), e talafeagai (2), ma e mafai ona fefaʻasoaaʻi uiga faʻasolosolo ma tulaga faʻapitoa laʻasaga i manu (3), ae o le biology o le televise faaagafesootai ua itiiti se suʻesuʻega. O faʻamatalaga mo se faʻapotopotoga o phobia fefaʻatauaiga ma faʻasologa masani i le polokalama o le dopamine e aofia ai le togafitiga o faʻamaoniga mo le initaneti o monoamine oxidase ae le o ni tigyclic antidepressants (4), le maualalo o le transporter i le televise telefoni faʻasalalau (5), maualalo le CSF maualuga o le vailaʻau oona i totonu o tagata maʻi le mautonu i le faʻatautaia o phobia telefoni (6), o se maualuga maualuga o telefoni faʻafesootai i tagata mamaʻi ma le maʻi o Parkinson (7), ma faʻateleina faailoga o le phobia i le taimi o le halopaleidol togafitiga o gasegase ma le maʻi o Tourette (8).
I lenei suʻesuʻega na matou faʻatusatusa ai le dopamine D2 taliga e mafai ona gafatia faʻamaʻi i tagata gasegase i televise telefoni faʻasalalau ma faʻataʻitaʻiga lelei faʻatusatusaga mataupu.
METHOD
E toʻasefulu taʻaloga faʻasalalau faʻapitoa na faʻauluina e faasalalauga faʻapitoa ma faʻamatalaga falemaʻi; o latou tausaga laʻititi o 32.5 tausaga (SD = 10.4), ma le vaega e aofia ai tane e lima ma le toʻalima tamaitai. O mataupu uma lava e maloloina faaletino e pei ona fuafuaina i iloiloga atoa faafomaʻi, e leai se mafaufauga i le taimi nei po o le olaga atoa, faaletonu o le mafaufau, popolega tele, maʻi pipili, faaletonu faʻanoanoa, le mautonu le faʻalavelave, maʻi faʻasolosolo posttraumatic, faʻafitauli o mea taumafa, faʻaleagaina poʻo le faʻalagolago, faʻasolosolo poʻo le lisiina o le amio a le tagata, po o le talafaasolo- pito o aiga o le valea. O le sefulu mea e faʻatusatusaina ai le soifua maloloina, e tutusa ma tausaga ma feusuaiga ma e leai ni faaletonu o le mafaufau i le taimi nei pe ua mavae, na faʻatautaia e le faasalalauga. Na faʻamaonia faʻamaumauga e ala i le faʻaaogaina o le Interview Clinical Structured mo DSM-IV Axis I Disorders (9).
O mataupu uma sa leai se vailaau o le mafaufau mo le itiiti ifo ma le tasi le tausaga, ma sa faia se vailaau faasaina aʻo lei suʻeina. Ina ua uma le faʻamatalaga atoa o le suʻesuʻega i mataupu, na maua mai se maliega tusitusia.
O le Liebowitz Social Situation Settlement (10) na faʻaaogaina e fuaina ai le matuia o telefoni faʻafesootai. D2 le fuaina o le faʻamalosia o le talini na fuaina i le faʻaaogaina o le leitio [123I] iodobenzamide ([123I] IBZM) faʻatasi ai ma le faʻatautaia o le faʻaogaina o le telefoni i luga o le photon, e ala i le bolus ma le faʻafesoʻotaʻiga faifai pea, pei ona faʻamatalaina muamua (11). O se faʻataʻitaʻiga o le tele-o-interest profile o le tele ma le faʻaauau o le faʻaaogaina e faʻavasega ai suʻesuʻega. O le itu taumatau ma le agavale o itumalo ma itulagi pito i tua na faʻatulagaina i luga o ata faʻapitoa. O le faʻamaufaʻailoga faapitoa na faʻatulagaina e pei o le eseesega i le va o galuega faʻapitoa ma le gaioiga i le matai. [123I] IBZM e mafai ona gafatia (i le ml / g), e tutusa ma le oloa o le tele o le tagata e taliaina le tali (BMax, i le MM po o picomoles i le gram o le faiʻai o le faiʻai) ma le faʻatasi (1 / KD, i le 1 / NM poʻo le milliliters o le plasma i le picomole o [123I] IBZM), na fuafuaina e pei o le fua faatatau o le fusi faapitoa (i microcuries per gram of the brain brain) i le tuumamaina o le plasma e le mafaatusaliaina le maualalo (i microcuries i le milliliter o plasma) (12).
O faʻatusatusaga a vaega na faʻaaogaina faʻataʻitaʻiga e lua e aunoa ma le totogiina o faʻataʻitaʻiga faʻatasi ma se pusa o le 0.05. E mafai ona fesoʻotaʻi le malosi o le fusiga i le faʻamalosia o le tino e ala i le faʻaliliuina o faʻamatalaga (Spearman rank correlation).
TULAFONO
E leai ni eseesega eseese o tagata i le matutua, feusuaiga, taʻaloga, aʻoga, tulaga o le ulugalii, poʻo le lima.
Sa i ai se eseesega taua i [123I] IBZM e mafai ona maua le gafatia i le va o vaega (t = 2.6, df = 18, p = 0.02), faatasi ai ma le maualalo o le gafatia i tagata gasegase i le televise telebia (mean = 93.6 ml / g, SD = 29.8) nai lo mataupu faʻatusatusa ( mean = 133.5 ml / g, SD = 38.2) (F1). I totonu o le vaega o fefaatauaiga lautele, sa i ai se tuufaatasiga le lelei o le mafai ona fusia faatasi ma le aofaʻiga atoa i le Liebowitz Social Axiety Scale (rs= -0.59, N = 10, p = 0.07).
TALANOAGA
O nei suʻesuʻega ua fautua mai ai e mafai ona fesoʻotaʻi faʻatasi le telefoni faʻasalalau i le maualalo o le D2 taliga e mafai ona gafatia i totonu o le vaega. Low D2 gaioiga o le faʻamalosia o le taligalu o le a ogatasi ma suʻesuʻega o le faiva o le polokalama o le laititi o le dopamine i telefoni faʻafesootai.
O lenei suʻesuʻega e tapulaa e le numera laʻitiiti o mataupu. E le gata i lea, ona e naʻo le tasi le faʻamalositino-faʻamalositino o galuega na faia i mataupu taʻitasi, D2 e le mafai ona fuaina le tele o le taligalu ma le vavalalata.
O mea na maua e foliga tutusa ma i latou mai suʻesuʻega a manu i le tulaga o tagata lautele, lea na fautuaina e faʻatalanoa uiga faʻale-aganuʻu ma feʻau faʻapitoa a le tagata. (3). Mo se faʻataʻitaʻiga, o se suʻesuʻega lata mai nei o suʻesuʻega o faʻataʻitaʻiga o manuki o le cynomolgus female (13) Faʻaalia le taʻi lalo ifo o le D2 e fusifusia i lalo ifo, e talitutusa ma la matou sailiga i le lautele o phobia masani. E mafai ona avea manu o le tulaga faʻapitoa laʻasaga ma se faʻataʻitaʻiga aoga mo le malamalama o le faiʻai o loʻo galue i lalo o le telefoni faʻafesootai tagata.
MF Low2 taliga o le taligalu e foliga mai e le itiiti ifo i se vaega faapitoa i phobia, nai lo le suiina o se faʻasalaga manino o le atuatuvale poʻo le le atoatoa o le mafaufau. D2 o le faʻamaonia e leʻi maua i lalo ifo o le vhizophrenia (14) poʻo le faʻalavelave tele (15). Ua lipotia mai o le maualalo o le faʻaaogaina o fualaau oona (16), lea e masani ona faʻamalosia i le telefoni fesoʻotaʻi (17).
O nei faʻamaumauga e taʻu mai ai le maualalo o D2 e mafai ona fesoʻotaʻi faʻatasi ma le telefoni faʻafesootai. Faʻatasi ma faʻamaumauga mai isi nofoaga autu, o nei faʻamatalaga faaopoopo i le faʻatupulaia o le faʻamaoniga o le D2 O le faʻatulagaga o le talipupuni e faʻaleleia ai amioga masani i totonu o tagata.
Maua le Fepuari 23, 1999; toe iloiloga na mauaina Iulai 13 ma Aug. 27, 1999; taliaina Sept. 2, 1999. Mai le Falemaʻi o Faʻafitauli Faʻafitauli ma le Vaega o Ata Faʻatau, o Niu Sila State Psychiatric Institute; ma le Department of Psychiatry, Columbia University College o fomaʻi ma fomai tipitipi, Niu Ioka. E leai ni kopi e maua. Faʻasalalau faʻasalalauga i le Dr. Schneier, Falemaʻi o Faʻafitauli Faʻafitauli, Unit 69, Institute of Psychiatric Institute a Niu Ioka, 1051 Riverside Dr., Niu Ioka, NY 10032; [imeli puipuia] (i-meli). Lagolagoina e fesoasoani mai le Sycamore Foundation ma mai Solvay Pharmaceuticals ma le NIMH Independent Scientist Award MH-01603 i Dr. Laruelle. Na faafetai ia tusitala ia Kathy Rivera, Tami Edwards, Janine Rodenhiser, Ph.D., Suehee Chung, Mali Pratap, Ted Pozniakoff, Richard Weiss, Dan Schneider, ma Analea Arevalo mo fesoasoani faʻapitoa.
Faʻaaliga 1.
Dopamine D2 Faʻafesoʻotaʻi le faʻamalosia o le faʻamaonia i tagata mamaʻi faʻatasi ma le lautele lautele o le vafealoaloai ma le soifua maloloina
mau faasino
Chartier MJ, Hazen AL, Stein MB: Tausaga masani o le telefoni faaagafesootai: o se suesuega lata mai o le faagasologa o fefaatauaiga masani i se faitau aofaʻi. Faʻatuʻuina le Faʻanoanoa 1998; 7: 113-121
[Toefaʻatau][PubMed][Toefaʻatau]
Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ: O le geneticiology o phobias i fafine: o fesoʻotaʻiga o agoraphobia, phobia telefonia, situational phobia, ma phobia faigofie. Arch Gen Psychiatry 1992; 49: 273-281
Manatua A: Faʻasaga i le manufeʻai ma matataʻu i foliga: popolega manu ma agafesootai e avea o ni faʻataʻitaʻiga mo suʻesuʻega o suʻesuʻega o lagona. Psychophysiol 1986; 23: 123-145
Liebowitz MR, Campeas R, Hollander E: O le a mafai ona faia le dopamine dysregulation i le telefoni masani ma le le mautonu o le mafaufau. Lapataiga Faʻapitoa Sipiʻi Res 1987; 22: 89-90
[Toefaʻatau][PubMed][Toefaʻatau]
Tiihonen J, Kuikka J, Bergstr�, Lepola U, Koponen H, Leinonen E: Dopamine toe faʻaleleia tulaga o nofoaga i tagata gasegase i le telefoni faʻafesootai. Am J Psychiatry 1997; 154: 239-242
Johnson MR, Lydiard RB, Zealberg JJ, Fossey MD, Ballenger JC: Plasma ma le CSF i tulaga faʻalavelave faʻalavelave ma le faʻatautaia o phobia. Biol Psychiatry 1994; 36: 426-427
Stein MB, Heuser IJ, Juncos JL, Uhde TUA: Faʻalavelave faʻalavelave i tagata gasegase i le maʻi o Parkinson. Am J Psychiatry 1990; 147: 217-220
Mikkelsen EJ, Detlor J, Cohen DJ: Aʻoga le aloese ma le telefoni faʻafesootai na mafua ona o haloperidol i tagata gasegase ma le faaletonu o Tourette. Am J Psychiatry1981; 138: 1572-1576
Muamua MB, Spitzer RL, Gibbon M, Williams JBW: Faʻatalanoaina o Falemai mo le DSM-IV Axis Disorders, Patient Edition (SCID-P), 2 1994. New York, New York State Institute of Psychiatric, Biometrics Research, XNUMX
Heimberg RG, Horner KJ, Juster HR, Safren SA, Brown EJ, Schneier FR, Liebowitz MR: O mea tau le mafaufau o le Liebowitz Social Settlement Scale. Psychol Med 1999; 29: 199-212
[Toefaʻatau][PubMed][Toefaʻatau]
Laruelle M, Abi-Dargham A, van Dyck CH, Rosenblatt W, Zea-Ponce Y, Zoghbi SS, Baldwin RM, Charney DS, Hoffer PB, Kung HF, Innis RB: FUAFUAGA ata faataitai o le dopamine i tua atu o le luitau o le amphetamine. J Nucl Med1995; 36: 1182-1190
Laruelle M, Abi-Dargham A, Al-Tikriti MS, Baldwin RM, Zea-Ponce Y, Zoghbi SS, Charney DS, Hoffer PB, Innis RB: Faatusatusaga o le [123I] iomazenil binding to benzodiazepine receptors in nonhuman primates, II: iloiloga paleni o suʻesuʻega faifai pea ma faʻafesoʻotaʻiga faʻatasi ma vailaau in vitro. J Cereb Blood Flow Metab 1994; 14: 453-465
[Toefaʻatau][PubMed][Toefaʻatau]
Grant Ka, Shively CA, Nader MA, Ehrenkaufer RL, Laina SW, Morton TE, Gage HD, Mach RH: Aafiaga o tulaga faʻalapotopotoga i luga o le DA D2 faʻamaumauga o loʻo faʻaaogaina i cynomolgus malekuki na suʻesuʻeina i totonu o le falemaʻi. Synapse 1998; 29: 80-83
[Toefaʻatau][PubMed][Toefaʻatau]
Laruelle M: Tuuina atu o le dopamine i le schizophrenia: o se toe iloiloga ma ni talatalanoaga. QJ Nucl Med 1998; 42: 211-221
Shah PJ, Ogilvie AD, Goodwin GM, Ebmeier KP: O le faʻasologa o le clinical ma psychometric o le dopamine D2 o loʻo fusifusia i le faʻalavelave. Psychol Med1997; 27: 1247-1256
Hietala J, West C, Syvalahti E, Nagren K, Lehikoinen P, Sonninen P, Ruotsalainen U: St2 le faʻamaumauga o le receptor o le dopamine i le olaola i tagata mamaʻi ma le ava malosi. Psychopharmacology (Berl) 1994; 116: 285-290
[Toefaʻatau][PubMed][Toefaʻatau]
Schneier FR, Martin LY, Liebowitz MR, Gorman JM, Klein DF, Fyer AJ: O le ava malosi ma le telefoni feaveaʻi. J Disfortiness Disord 1989; 3: 15-23
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