J Neurosci. 2012 Jun 27; 32 (26): 9023-9034.
Anzalone A, Lizardi-Ortiz JE, Ramos M, De Mei C, Hopf FW, Iaccarino C, Halbout B, Jacobsen J, Kinoshita C, Welter M, Caron MG, Bonos A, Sulzer D, Borrelli E.
puna
Matagaluega o Suesuega Faasaienisia ma le Molecular Genetics, INSERM U904, University of California Irvine, Irvine, Kalefonia 92697, Department of Psychiatry, Columbia University, New York, New York 10032, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, Kalefonia 94608, Matagaluega o Cell Biology, Falemaʻi Falemaʻi a Duke, Durham, North Carolina 27710, Polokalame Suʻesuʻega Faʻafesoʻotaʻi, National Institute on Drug Abuse, Baltimore, Maryland 21224, ma Matagaluega o Neurology and Pharmacology, Columbia University, Niu Ioka, New York 10032 .
lē faʻatino
O faʻafitauli o le dopaminergic homeostasis e oʻo atu i le maualalo poʻo le maualuga o le maualuga o le dopamine (DA) e fesoʻotaʻi ma le faʻamaʻi a Parkinson, schizophrenia, ma vaisu. Nofoaga tele o le synthes DA o le mesencephalic neurons e afua mai i le substantia nigra ma ventral tegmental area; nei fausaga auina tetele faʻatatauga i le dorsal striatum (DSt) ma nucleus accumbens (NAcc), faʻatulagaina. Faʻalelei lelei e le DA lana lava faʻasologa ma faʻasaʻolotoina e ala i le faʻagaoioia o DA D2 taliaina (D2R). I le taimi nei, o lenei faitioga taua-faalagolago i le D2R na manatu e mafua ona o le faʻagaoioia o D2Rs i luga o neurone dopaminergic (D2 autoreceptors); Ae ui i lea, o le faʻaaogaina o isumu faʻapitoa o le D2R tuʻituʻi fafo, matou te iloa ai o le D2 heteroreceptors o loʻo tu i luga o le non-DAergic medium spiny neurons e auai i le faʻatonutonuina o le maualuga o le DA. O lenei D2 heteroreceptor-mediated mechanism e sili atu le lelei i le DSt nai lo le NAcc, e faʻaalia ai o le D2R signaling eseese faʻatonutonu mesolimbic- versus nigrostriatal-mediated functions. O lenei suʻesuʻega na aliali mai ai talu ai le le talisapaia le faʻatonutonuina o le saini a le DA, faʻamalamalamaina le malamalama fou i le itulagi-faʻatonutonu faʻatonutonuina o DA-faʻatonutonuina aafiaga
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