Int J Androl. 2011 Dec 13. Pule: 10.1111 / j.1365-2605.2011.01230.x.
Nyante SJ, Graubard BI, Li Y, McQuillan GM, Platz EA, Rohrmann S, Bradwin G, McGlynn KA.
puna
Vaega o Kanesa Epidemiology ma Genetics, National Cancer Institute, Bethesda, MD Matagaluega o le Matematika, Iunivesite o Texas i Arlington, Arlington, TX National Center mo Soifua Maloloina Fuainumera, Hyattsville, MD Matagaluega o Epidemiology, Johns Hopkins Bloomberg Aoga a le Soifua Maloloina Lautele, Johns Hopkins Iunivesite, Baltimore, MD, USA Vaega o Kanesa Epidemiology ma Puipuiga, Inisetiute o agafesoʻotaʻi ma Puipuiga Faʻafomaʻi, Iunivesite o Zurich, Zürich, Suiselani Matagaluega o Laboratory Faʻafomai, Harvard Medical Aoga ma Falemai Fanau, Boston, MA, USA.
lē faʻatino
O suʻesuʻega muamua na fautua mai ai o le tane testosterone concentrations ua faʻaitiitia i le taimi. Ina ia suʻesuʻeina lenei mea i le tele o tagata Amerika, matou te suʻesuʻeina le testosterone ma le free testosterone concentrations i le National Health and Nutrition Exams (NHANES) mai le 1988-1991 ma le 1999-2004. Na matou suʻesuʻeina foi i le homone-binding globulin (SHBG), estradiol, ma le androstanediol glucuronide (3α-diol-G) i le vaitaimi lava e tasi. Le-Hispanic papaʻe, leai-Hispanic uliuli, ma tagata Mekisiko-Amerika mai le 1988-1991 ma le 1999-2004 NHANES suʻesuʻega na ≥20 tausaga ma na maua le serum mai taeao tosoina toto na aofia ai i lenei auiliiliga (1988-1991: N = 1,413; 1999-2004: N = 902). O le testosterone, estradiol ma le SHBG na fuaina e le tauvaga electrochemiluminescence immunoassays ma le 3α-diol-G na fuaina e le enzyme immunoassay. Ole fua ole testosterone na faʻatulagaina e faʻaaogaina ai testosterone ma SHBG. Fetuunaiga o lona uiga o homone concentrations sa fuafuaina e faʻaaogaina laina laina, fuafua mo NHANES faʻataʻitaʻiga mamafa ma mamanu, tausaga, tuʻuga / ituaiga, tino vaega tele, sulugatiti, faʻaaogaina o le ava malosi ma ulaula. Eseesega i fetuʻunaʻiga o mea faʻatulagaina (two) ma itu-taʻi p-faʻatauaina na fuafuaina; p <0.05 sa taua tele ile fuainumera. I le aotelega, o le 3α-diol-G ma le estradiol na teʻena i le va o le 1988-1991 ma le 1999-2004, ae e laʻititi lava le suiga i le testosterone, maua fua le testosterone, poʻo le SHBG (Δ: 3α-diol-G = -1.83 ng / mL, p <0.01 ; estradiol = -6.07 pg / mL, p <0.01; testosterone = -0.03 ng / mL, p = 0.75; free testosterone = -0.001 ng / mL, p = 0.67; SHBG = -1.17 nmol / L, p = 0.19) . Faʻamaonia i tausaga ma tuʻuga na faʻaalia ai o SHBG ma le 3α-diol-G na paʻuʻu i totonu o tagata papaʻe 20-44 tausaga le matua (Δ: SHBG = -5.14 nmol / L, p <0.01; 3α-diol-G = -2.89 ng / mL, p <0.01) ma maua fua testosterone faʻateleina i uli 20-44 tausaga (Δ: 0.014 ng / mL, p = 0.03). Estradiol na teʻena i tausaga uma o papalagi ma Mekisiko-Amerika.
I le faaiuga, e leai se faʻamaoniga mo le testosterone o loʻo paʻu i le va o 1988-1991 ma 1999-2004 i le numera lautele o le US. O iloiloga a vaega vaega e fautuaina ai le teena e le SHBG ma le 3A-diol-G i alii talavou papaʻe, le teena leradio i tagata papaʻe ma Mexiko-Amerika, ma le testosterone saoloto na faateleina i alii talavou. O nei suiga e mafai ona fesoʻotai i le faʻalauteleina o le faʻalavelave o faʻafitauli o le fananau mai i alii talavou.
© 2011 Le Tusitala. Faʻasalalauga Faʻavaomalo o Andrology © 2011 European Academy of Andrology.
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