Front Pharmacol. 2018 Iulai 27;9:821. doi: 10.3389/fphar.2018.00821.
Tau AE1, Anastasio NC1,2, Stutz SJ1, Hommel JD1,2, Cunningham KA1,2.
lē faʻatino
Binge eating disorder (BED) e faʻaalia i le faʻaleagaina o meaʻai hedonic ma faʻagasologa o taui. Fa'agaoioia o le serotonin (5-HT) 5-HT2C talitali (5-HT2CR) fa'agata uma mea'ai ma amioga fa'atatau i taui ma fa'apea e fa'atonuina le BED. O lenei suʻesuʻega na suʻesuʻeina ai aʻafiaga o le 5-HT2CR fa'agaoioia e ala i le filifilia 5-HT2CR agonist WAY163909 i uiga fa'atauva'a fa'atatau i le 'ai i iole tane matutua Sprague-Dawley. O tui maualalo ole WAY163909 (1.0, 2.0 mg/kg) e taofia ai le taumafaina o mea'ai ga'o maualuga (HFF), ae le o mea'ai masani e le'i fa'atau. WAY163909 (1.0 mg/kg) fa'ato'a fa'ato'ilaloina fo'i le tali atu mo pellets HFF fa'afoe e le tagata lava ia i luga o fa'asologa fa'aopoopo ma fa'agasolo fa'asologa o le fa'amalosi, fa'ailoa mai o le 5-HT.2CO le fa'agaoioiga o le R e taofia ai le fa'amalosia ma le fa'amalosia o meatotino a le HFF, fa'asologa. O nei suʻesuʻega o loʻo fautua mai ai o le faʻagaoioia o le 5-HT2CR atonu e aoga i le taofiofia o le 'ai tele i tagata mamaʻi ma le BED e ala i taofia o le faʻamalosia ma le faʻamalosia o meatotino a le HFF. O lenei galuega e lagolagoina suʻesuʻega i le lumanaʻi e faʻatatau i le 5-HT2CR ile togafitiga ole BED.
FUAFUAGA:
5-HT2C talitali; 'ai tele; mea'ai ga'o maualuga; fa'aosofiaga; serotonin
PMID: 30100875
PMCID: PMC6072841
FAIA: 10.3389/fphar.2018.00821
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