ACS Chem Neurosci. 2019 Aper 1. doi: 10.1021 / acschemneuro.8b00601.
Yohn S., Galbraith J, Calipari E., Conn PJ.
lē faʻatino
O faʻamaumauga tuʻufaʻatasi mai falemaʻi ma faʻataʻitaʻiga suʻesuʻega fautua mai ai i vailaʻau faʻasaina ma setete o le soona 'ai, pei o le lapoʻa ma le faʻatamaʻia o le' ai (BED), e i ai le le paleni i taʻamilosaga e taua mo le faʻaosofia, taui saliency, pulega faʻatinoina, ma oe lava faʻatonutonu. . Tutotonu i nei pathologies ma le lautele autu o lenei iloiloga o le aberrations i le dopamine (DA) ma le glutamate (Glu) i totonu o le mesolimbic auala. Vaega I metabotropic glutamate taliaina o loʻo faʻaalia tele i auala mesolimbic ma ua sauni i tulaga taua e faʻafetaui le faʻalavelave i le synaptic plasticity ma le neurotransmitter faʻasaʻolotoina matauina i vailaʻau faʻasāina, lapoʻa ma BED. O le faʻaaogaina o allosteric modulator o le kulupu I metabotropic glutamate receptor (mGluRs) na suʻesuʻeina i vailaʻau faʻasaina, ona latou te ofoina atu le tele o tulaga lelei nai lo aganuʻu masani orthosteric agents. Ae ui i lea, latou te leʻi suʻesuʻeina i le lapoʻa poʻo le BED. Faatasi ai ma le tele o soʻoga i le va o le neurocircuitry aʻafia i vailaʻau fai ma vaisu ma 'ai faʻaletonu, kulupu I mGluRs mafai foi ona maua ai ni sini fou mo gaʻoa ma BED.
PMID: 30933466
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