Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Mar;2(2):188-195. doi: 10.1016/j.bpsc.2016.03.001.
Yip SW1, Morie KP2, Xu J2, Leoleo RT3, Malison RT4, Carroll KM2, Potenza MN5.
lē faʻatino
FAʻAMATALAGA:
E iai mea e tutusa ai amioga ma vaisu. Ae ui i lea, o le faʻatusatusaga tuusaʻo o le neurobiological i le va o faʻafitauli o mea ua fai ma vaisu e seasea. Fuafuaga o le faaletonu-faʻapitoa (poʻo le leai) o suiga i totonu o microstructures paʻepaʻe o le a faʻalauteleina le malamalama i le pathophysiology o vaisu.
METHODS:
Na matou faʻatusatusaina mea paʻepaʻe microstructural vaega i le va o tagata taʻitoʻatasi e iai le faʻalavelave tau tupe (GD; n = 38), faʻamaʻi faʻaoga cocaine (CUD; n = 38) ma faʻatusatusaga maloloina (HC; n = 38) tagata auai, e pei ona iloiloina e faʻaaoga ai le faʻamaneta faʻamaneta. fa'ata'ita'iga fa'afoliga (dMRI). Ina ia maua se fa'atusatusaga sili atu ona sa'o o le fa'asalalauga i totonu o itulagi o fa'ata'ita'iga lavelave (fa'ata'ita'iga, cortico-limbic tracts), sa fa'atinoina su'esu'ega i le fa'aogaina o se fa'ata'ita'iga felavasa'i fa'atasi ma fa'ata'ita'iga fa'alotoifale (tbss_x). Anisotropy fua faatatau mo tulaga muamua ma lona lua fiber orientations na faʻatusatusa i le faʻaaogaina o ANOVA faʻasaʻo mo le tele o faʻatusatusaga i luga o le avanoa e faʻaogaina ai le faʻaleleia o fuifui e leai se avanoa (pFWE<.05).
TULAFONO:
O se aafiaga autu o le vaega i luga o le anisotropy o lona lua fiber orientations i totonu o le agavale i totonu capsule, corona radiata, forceps tele ma posterior thalamic radiation, e aofia ai le faaitiitia o le anisotropy i le GD ma le CUD tagata auai pe a faatusatusa i tagata auai HC. Leai se eseesega i fua anisotropy na maua i le va o tagata GD ma CUD.
FAAIUGA:
O le suʻesuʻega muamua lea e faʻatusatusa faʻamatalaga faʻasalalau saʻo i le va o vaisu o amioga ma vailaʻau ma le tele o suʻesuʻega dMRI a le GD. O a matou suʻesuʻega o loʻo faʻaalia ai suiga tutusa microstructural paʻepaʻe i vaisu e le mafai ona faʻatatau naʻo le faʻaalia i vailaʻau poʻo le ava malosi ma mafai ai ona avea ma se faʻalavelave faʻalavelave mo faʻafitauli o vaisu.
FUAFUAGA: faaletonu o le faaaogaina o le ava; vaisu tau amio; fa'ata'ita'iga fa'asalalauina (DTI); impulsivity; pathological taaloga faitupe; fa'aletonu o le fa'aaogaina o vaila'au
PMID: 28367515
PMCID: PMC5373810
FAIA: 10.1016/j.bpsc.2016.03.001
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