Vaefaʻavalevale: O Se Faʻataʻitaʻiga o le Faʻateleina o Amio Lelei? (2006)

FAʻAALIGA: E tusa ai ma lenei pepa, o le pisapisao isumu o se lelei faʻataʻitaʻiga mo tagata vaisu - uma amio ma vailaʻau. O le fafagaina o isumu meaʻai suamalie i luga o taimi le masani ai e faʻamalosia ai le amio faʻapipiʻi Suesuega i luga o faiʻai o nei bingeing rat o loʻo faʻaalia ai le neurobiology o vaisu mo tagata.

Suesuega Atoa: Faʻatauga o Faʻatauga: O Se Faʻataʻitaʻiga o le Faʻateleina o Amio Lelei?

Manatu. 2006 Jan; 46 (1): 11-15.

Lomia i luga o le initaneti 2005 Sep 26. Tui: 10.1016 / j.appet.2004.09.002

PMCID: PMC1769467

NIHMSID: NIHMS15066

Rebecca L. Corwin

lē faʻatino

O le tele o amioga le talafeagai (IEB) e faʻaalia ai faʻafitauli eseese o tagata, e aofia ai le 'aiina o meaʻai, faʻaaogaina o fualaau faasaina, ava malosi, amio faʻafeusuai, ma le faʻamalosi tupe. O loʻo i ai i le IEB le faʻamaʻi faʻamaʻi pipisi, ma o loʻo avanoa avanoa tau togafitiga. O le faʻaaogaina o faʻataʻitaʻiga faʻalelei o le taloina ma isi faʻailoga faʻailoga ua amata ona faamanino ai mea e tutusa lelei ma eseesega o loʻo i ai i le va o le IEB e faʻatatau i le mauaina ma le faʻaaogaina o meaai ma le IEB i le mauaina ma le faʻaaogaina o fualaau oona. O suʻesuʻega mai lenei potu suʻesuʻe e faʻaaoga ai se tapulaa faʻafeiloaʻi e mafai ona maua ai se faʻataʻitaʻiga e mafai ona maua ai se faʻamatalaga fou i le IEB.

uputatala: Tausiga o Binge, Faʻatauga o mea, mea faʻalelei

O a mea e le mautonu, amioga tele?

O amioga soʻona fai faʻasolitulafono (IEB) e faʻailoa mai ai le tele o faʻaletonu o le tagata e aofia ai le taumafa tele i fualaʻau, faʻaogaina o fualaʻau faʻasaina, 'ava malosi, amioga faʻasotoma leaga, ma le faʻamalosi tupe. O nei amioga e fesoʻotaʻi ma le faʻateleina o le gasegase ma le olaga faitino, ae o loʻo tumau e ui lava i le leaga faʻaiuga e fesoʻotaʻi ma latou. I nai tausaga ua tuanaʻi, o le faʻateleina o le uaʻi na ave i le malamalama i le neurobiological faʻavae o le vaʻavaʻaia vaega o amioga sili atu, faʻatasi ai ma taumafaiga faapitoa taulaʻi i le faʻaititia o le faʻaogaina o fualaʻau ma le soona faʻaaoga o meaʻai. O le faʻamoemoe o le faʻamalamalamaina o le neurobiological faʻavae o se tasi ituaiga o amioga (eg fafagaina) o le a faʻalauteleina ai lo tatou malamalama i isi ituaiga o amioga (eg faʻataʻitaʻiga fualaʻau). Lenei o le a maua ai se faʻavae mo le atiaʻeina o togafitiga fou faʻapitoa e mafai ona aoga i le tele o faʻaletonu. E ui lava, talu ai nei lipoti faʻailoa mai le alualu i luma i le falemaʻi falemaʻi togafitiga o faʻafitauli aofia ai bingeing ma nisi vaisu, togafitiga togafitiga tumau tapulaʻa ma toe paʻu fua maualuga (de Lima, Soares, Reisser, & Farrellde, 2002; Halmi, Agras, Mitchell, Wilson, Crow ma Bryson, 2002; Kreek, LaForge, & Butelman, 2002; Sili atu le saogalemu, olaola, Telch, & Agras, 2002; Zhu & Walsh, 2002).

I totonu o tagata, o le IEB e faasino i le faʻaaogaina o meaai atonu e sili atu ona lelei le faʻatusalia e le pinge eating. O le taumafa o Binge e aofia ai le faʻateleina o le taumafa i ni taimi pupuu i se aofaiga e sili atu nai lo le tele o tagata e ai i lalo o tulaga faapena. E mafai pe le mafai ona mulimulitaia e le tulafono le faʻamaonia o amioga e pei o le vomiting ('faʻamamaina'), anapogi, poʻo le mamafa tele. I le gasegase o mea taumafa e aʻafia ai, e faʻapope ona faʻaosoina i luga ole taimi uumi ma e fesoʻotaʻi ma se lagona o le leai o se pule ma le faʻalagona lagona (DSM-IV, 1994).

Binge taumafaina faʻasoa faʻatasi ma isi IEB. Mo se faʻataʻitaʻiga, o fomaʻi e sailia togafitiga mo le ava malosi ma le faʻaleagaina o le cocaine e maua ai le maualuga o le pinge eating (Johnson, Spitzer, Williams, Kroenke, Linzer ma Brody, 1997; Wilson, 1993), ma o le faitau aofai e saili togafitiga mo faʻafitauli o le taumafa o le pingeing e maua ai le maualuga o fualaau o vailaʻau, aemaise lava o le ava malosi ma le cocaine (Brewerton, Lydiard, Herzog, Brotman, O'Neill ma Ballenger, 1995; Bulik, Sullivan, & Kendler, 2002; Bushnell et al., 1994; Herzog et al., 1992; Laessle, Wittchen, Fichter, & Pirke, 1989; Wiederman & Pryor, 1996). O se mafutaga i le va o le pinge eating and gambling has also reported (Engwall, Hunter, & Steinberg, 2004).

O le faʻamaualuga i le IEB ua fautua mai ai e mafai ona sola ese auala e fefaasoaaʻi ai nei amioga. O faʻataʻitaʻiga manu e manaʻomia e suʻesuʻe ai suiga e tutupu i le taimi o le IEB, faʻaleleia, ma toe foʻi, ma faʻatusatusa tutusa ma eseesega i le va o vasega IEB eseese. O faʻamaufaʻailoga e faʻaaoga ai taui masani e pei o meaai e taua tele ona o lo latou gafatia e faʻaalia suiga e tutupu pe a oʻo i taimi e masani ai ona faʻataunuʻuina le amio masani (eg faʻapipiʻi i nisi o taimi) e avea ma faʻasolosolo, faʻalavelave, faʻafeusuaʻiga amioga faʻaleagaga (eg faʻasolosolo pea). E tele ni faʻataʻitaʻiga faʻale-amio o le taloina o le taloni, ua uma ona faʻatulagaina, lea na toe iloiloina talu ai nei (Corwin & Buda-Levin, 2004). O le faʻaaogaina o nei tulafono ma isi faʻataʻitaʻiga o loʻo amata ona faamanino ai mea e tutusa ma le eseesega o loʻo iai i le va o le IEB e faʻatatau i meaai ma le IEB e faʻatatau i fualaau faʻaleagaina (mo se faʻataʻitaʻiga, Bello, Sweigart, Lakoski, Norgren, & Hajnal, 2003; DeSousa, Bush, & Vaccarino, 2000; Di Chiara, 2002; Gosnell, 2000; Grigson, 2002; Hagan & Moss, 1991; Kelley & Berridge, 2002; Schroeder, Binzak, & Kelley, 2001; Spangler, Wittkowski, Goddard, Avena, Hoebel ma Leibowitz, 2004).

Totoina o rati ma le IEB

O le tapulaa faʻasalalau avanoa

O suʻesuʻega mai lenei fale suesue ua tuʻuina atu i le atinaʻeina o se faʻataʻitaʻiga o le taumafa o le pinge lea e le manaʻomia ai le faʻamalosia o le malosi, ina ia faʻaitiitia ai le faʻaleagaina o aʻafiaga e fesoʻotai ma meaʻai-leai. O le mea lea, o mea uma e faʻaaogaina i totonu o fale suesue ma vai e maua i taimi uma i totonu o la tatou feagaiga. Mo le faatosinaina o le taumafa-pinge-type, o le avanoa faatapulaa i se punaoa filifilia o gaʻo meaʻai (gaosia o le gaosiga o le gaosiga o le suavai) ua saunia. O la matou suʻesuʻega ua faʻaalia ai, e pei o le faʻaititia o le faʻaitiitia o le faʻaititia, o le faʻaaogaina o le faʻapuupuuga o le faʻapuupuuga i le taimi o le 2-h avanoa avanoa (Corwin, 2004; Corwin, Wojnicki, Fisher, Dimitriou, Rice ma le Young, 1998; Dimitriou, Rice, & Corwin, 2000; Thomas, Rice, Weinstock, & Corwin, 2002). A maua e rati le faʻapuupuuga mo le 2 i le tolu taimi i le vaiaso, o le meaʻai i le taimi o le 2-h avanoa avanoa e matua maualuga lava, o lona uiga e tutusa lelei ma aumei ma faʻaauau ona avanoa i le faʻapuʻupuʻu faʻaaoga i le 24 h. O le faʻavaeina o nei mea maualuga e faʻatatau i 4 vaiaso. Ae ui i lea, pe a faʻamautuina, e faigofie ona tausia le amio. O lenei maliega e maua ai se auala faigofie ma e le taugata e faʻavae ai le IEB lea e mafai ona tausia mo taimi uumi. O le tulaga malosi e malosi ma faʻatuatuaina, e pei ona tatou faʻaalia i le tele o aʻafiaga ma tausaga o kio (Thomas et al., 2002), faapea foi i alii ma tamaitai (Corwin et al., 1998; Dimitriou et al., 2000).

O lapisi e mafai ona faʻapuʻupuʻu mo le 2 i le Mon, Weds, Fri (MWF) i vaiaso taitasi e le totogiina ai le tele o le malosi e faʻaaogaina i le taimi o le vevela i le 22 i le maeʻa o le mea o le binge. O lona uiga, o le faʻaaogaina tele i le taimi o le 2-h binge e mafua ai le eletise 24-h sili i le aso o le binge. Ae peitai, i aso mulimuli ane e le o ni aso, e le gata i lea, o le 24-h ua faʻaitiitia le faʻaaogaina o le malosi. O le mea lea, o se faʻasologa o le amio mama / faʻasalaga e atiaʻe ai i le MWF kusi, e ui lava e le mafai ona faʻaaogaina meaai; naʻo lo latou avanoa i le faʻapuupuuga e gata. O le mamanu o le taumafaina o meaai i Motu a le MWF e ese mai i ituaiga o kioti o loʻo tausia i le aso 2-h faasoloatoa avanoa avanoa. O le aso 24-h o taumafa i totonu o na kusi e le ese mai le puleaina o na o le tele o aso.

O le mea moni o le pipiiina i le tapulaa faʻatapulaʻaina o loʻo faʻateleina e ala i le faʻamapulaʻaina o se mea e sili ona lelei e maua ai le meaʻai, aua o meaʻai e taofi e tagata e masani lava ona aofia ai mea faasaina ma meaʻai e faasaina (DSM-IV) ; Guertin, 1999; Hadigan, Kissileff, & Walsh, 1989; Kales, 1990; Rosen, Leitenberg, Gross, & Willmuth, 1986). E le gata i lea, o le faatapulaaina o avanoa i mea taumafa o mea taumafa e faateleina ai lo latou taumafaina mulimuli ane i totonu o se potu suesue faatulagaina (Fisher & Birch, 1999). O le mea moni e faʻapea, e leai se meaʻai e maua mai i meaʻai-pei o le 'ai i le leai o se fiaʻai e fesootaʻi ma le pipiʻi i tagata (Marcus & Kalarchian, 2003). O le amio a manu i luga o le tapulaʻa faʻatapulaʻaina, o le mea lea, e fetaui lelei i le taumafa o tagata, ma tutusa i nisi o tagata o loʻo mafatia i faʻafitauli o mea taumafa e aʻafia ai le pingeing.

Pepides e faʻasaoina ai le gaosiga o le gaʻo e leai se aoga i lalo o tuutuuga avanoa

I faʻasalalauga e le faʻaaogaina, o le galanin e faʻateleina ai le taumafa o mea taumafa pe a faʻatonu saʻo i totonu o le nofoaga faʻasolosolo o le hypothalamus (Corwin, Robinson, & Crawley, 1993; Kyrkouli, Stanley, Seirafi, & Leibowitz, 1990), ma o le taulalata o le M40 e faʻaitiitia ai le faʻaaogaina o gaʻo (Leibowitz & Kim, 1992). Ae ui i lea, pe a tofotofoina i lalo o tuutuuga avanoa e le mafai e le galanin poʻo le M40 ona aafia ai le gaʻo o le gaʻo (Corwin, Rowe, & Crawley, 1995). Na maua foi tali tutusa ma le enterostatin, o se mafaufauga neuropeptide e saofagā ai i le satisite gaʻo (mediated satiety)Erlanson-Albertsson & York, 1997). O lona uiga, i lalo o tuutuuga faʻatapulaʻa, o le enterostatin e leai sona aoga i le taumafaina o mea taumafa (Corwin & Rice, 1998; Rice & Corwin, 1996, 1998). O nei suʻesuʻega o loʻo taʻu mai ai o le neurobiology o le gaʻo i le faʻatapulaʻaina o avanoa avanoa e ese mai le neurobiology o le gaʻo gaʻo i lalo o isi tulaga.

O le faʻauʻuina e ala i le faʻatapulaʻaina o avanoa atonu e pei o le faʻaaogaina o vailaʻau

O suʻesuʻega talu ai nei na amataina e suʻe ai mea e ono tutusa ai le gaʻo o le gaioiga e aʻafia e ala i le faʻatapulaʻaina o avanoa ma se isi IEB, faʻaaogaina o vailaʻau. O lipoti mai isi vaega ua faaalia ai o le GABA-B agonist baclofen e faaitiitia ai le puleaina o fualaau oona i manu (Fattore, Cossu, Martellotta, & Fratta, 2002; Janak & Gill, 2003; Ranaldi & Poeggel, 2002; tagai foi Brebner, Phelan, & Roberts, 2002; Cousins, Roberts, & de Wit, 2002, mo iloiloga), ma ua faʻaalia ile aoga i le togafitiga o vailaau faʻasaina ma le faʻalagolago (Addolorato, Caputo, Capristo, Domenicali, Bernard ma Janiri, 2002; Assadi, Radgoodarzi, & Ahmadi-Abhari, 2003; Shoptaw, Yang, Rotheram-Fuller, Hsieh, Kintaudi ma Charuvastra, 2003; Vaʻai foi Brebner et al., 2002; Cousins et al., 2002, mo iloiloga). O faʻamatalaga lata mai nei mai lenei potu suʻesuʻe ua faʻaalia ai o le afaina e faʻaitiitia ai le faʻaaogaina o le gaʻo o le gaʻo e aʻafia e ala i le faʻatapulaʻaina o le avanoa e aunoa ma le faʻaitiitia o le taumafa o se meaʻai tele-gaʻo poo le au (Buda-Levin, Wojnicki, & Corwin, 2005). E manaia tele lenei mea ona o le tuiina ma le faʻaaogaina o vailaau e faʻaaogaina ai le faʻamalosia o le tino (Brewerton et al., 1995; Bulik et al., 2002; Bushnell et al., 1994; Herzog et al., 1992; Johnson et al., 1997; Laessle et al., 1989; Wiederman & Pryor, 1996; Wilson, 1993) ma le afaina i le lautele e leai se aafiaga i luga pe faateleina ai le taumafa i meaʻai i totonu o faʻasalaga o manu (Brebner et al., 2000; Ebenezer, 1995; Echo, Lamonte, Ackerman, & Bodnar, 2002; Higgs & Barber, 2004; Minano, Meneres Sancho, Sancibrian, Salinas, & Myers, 1992; Stratford & Kelley, 1997; Ward, Somerville, & Clifton, 2000; Wirthafter, Stratford, & Pitzer, 1993; Znamensky, Echo, Lamonte, Kerisiano, Ragnauth ma Bodnar, 2001). I le tuufaatasiga, o nei sailiiliga e taʻu mai ai o le faʻailoga faʻailoga e aofia i le faʻauluina o le talo, e pei ona faʻataʻitaʻiina i le tapulaa faʻatapulaʻaina, e ese mai i le le 'aiina o meaai. Nai lo o lea, o faailo o le neural talafeagai i le IEB o le bingeing atonu e sili atu ona vavalalata ma i latou o aafia i le IEB o le faʻaaogaina o vailaʻau.

faaiuga

O le neurobiology o le faifai pea, le mautonu, o vaega o le amio le pulea e le o malamalama lelei i ai. Ae ui i lea, o molimau liliu mai e taʻu mai ai o mea masani e mafai ona fesoasoani i faʻafitauli e aafia ai lenei ituaiga amioga. O suʻesuʻega mai lenei potu suʻesuʻe ua faʻaalia ai le faatapulaaina o avanoa i le faʻapuupuuga e mafai ona faʻanofoina ai, faifai pea, faʻateleina le faʻaogaina o le faʻapuupuuga o tamaiti e leai ni meaʻai. O le maliega e faigofie ma e le taugata, ma o le amioga e tutusa i nisi o auala e pipiʻi ai tagata. Faʻamatalaga talu ai nei, o le faʻailoga i totonu o le faʻatapulaʻaina o tulaga faʻapipiʻi ituaiga e ese mai tulaga e le o vaʻaia, ma atonu e sili atu ona vavalalata ma le faʻaaogaina o vailaʻau. O loʻo i ai nei le tele o faʻaiʻuga fafagaina e mafai ona faʻaaoga e faʻaleleia ai lo matou malamalama i suiga o le physiological ma le neurological e tutupu ona o le auai i le IEB. O ia suʻesuʻega e taua tele pe afai e tatau ona tatou faʻamalosia auala e fesoasoani i le atinaʻeina, tausiga, ma toe foʻi i nei faʻaoga masani o amioga.

tautinoga

Faʻaalia i le Society for the Study of Ingestive Behaviour (SSIB) Satellite Symposium, Hueston Woods Resort, Ohio, Iulai 18–20, 2004. Taitaifono ai Allan Geliebter ma Harry R. Kissileff. O le satelite na lagolagoina i se vaega e le New York Obesity Research Center, SSIB, General Mills Foods, McNeil Nutrals, Ortho-McNeil Pharmaceuticals, Procter & Gamble.

mau faasino

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