Jokinen, Jussi
Iunivesite o Umeå, Faculty of Medicine, Department of Clinical Sciences.ORCID iD: 0000-0001-6766-7983
Flanagan, Ioane
Chatzittofis, Andreas
Iunivesite o Umeå, Faculty of Medicine, Department of Clinical Sciences.
Oberg, Katarina
Aotelega [en]
Talaʻaga: O le gasegase feusuaʻiga (HD) tuʻufaʻatasia vaega pathophysiological pei o le tuinanau manaʻoga deregulation, feusuaʻiga faʻamalosi, impulsivity ma compulsivity na fautuaina o se faʻamaoniga mo le DSM-5. "Faʻamalosi amioga faʻafeusuaiga faʻaletonu" ua avea nei o se faʻatonutonu-faʻatonutonu le faʻamaʻi i le ICD-11. O suʻesuʻega talu ai nei na faʻaalia ai le faʻaleagaina HPA 'au i aliʻi ma HD. Oxytocin (OXT) afaina ai le gaioiga o le HPA axis; leai ni suʻesuʻega na suʻesuʻeina tulaga OXT i tagata mamaʻi ma HD. Pe o le CBT togafitiga mo HD faʻailoga ei ai se aʻafiaga i luga o le OXT tulaga e leʻi suʻesuʻeina.
Metotia: Na matou suesueina le OXT o le plasma i 64 tamaʻitaʻi ma le HD ma 38 tamaʻitaʻi e tutusa lelei ma le soifua maloloina. E le gata i lea, sa matou suʻesuʻeina fesoʻotaʻiga i le va o le OXT o le plasma ma le faʻailoga ole HD o loʻo faʻaaogaina ai le fua faatatau e fuaina ai le amio faʻaletagata: O le suʻesuʻega ole faʻailoaina o le tino (HDSI) ma le fua o le Sexual Compulsive (SCS). O se vaega o tagata gasegase (N = 30) faʻamaeʻaina le tusi faʻavae-vaega vaega-faʻatautaia CBT polokalame mo HD ma sa i ai se tulaga faʻalua o OXT i le maeʻa o togafitiga. OXT na fuaina ma Radioimmunoassay (RIA).
I'uga: O tagata mama'i i le HD na sili atu le maualuga o le OXT (Mean 31.0 ± SD 9.9 pM) fa'atusatusa i volenitia soifua maloloina (Mean 16.9 ± SD 3.9 pM) (p <0.001). Sa i ai ni fesoʻotaʻiga lelei i le va o le OXT ma le fua faʻatatau e fuaina ai amioga faʻafeusuaiga (Spearman rhos i le va o le HDSI r = 0.649, p <0.001 ma le SCS r = 0.629, p <0.001) i le au suʻesuʻe tuʻufaʻatasia. O maʻi na faʻamaeʻaina togafitiga CBT na faʻaititia tele le maualuga o le OXT mai le muaʻi togafitiga (30.5 ± 10.1pM) i le maeʻa togafitiga (20.2 ± 8.0pM) (p <0.001). O maʻi ma HD sa i ai se faʻamaopoopo lelei tele o latou suiga ile HD: CAS faʻatasi ai ma le plasma oxytocin maualuga i luma ma pe a uma le CBT (r = 0.388, p tau = 0.0344).
Faʻaiʻuga: O faʻaiʻuga e fautuaina ai le hyperactive oxytonergic system i tamaʻi maʻi o le tino feʻaveaʻi e ono avea ma auala e faʻamalosia ai le faʻaitiitia o le faʻamalosi o le toto. O se manuia o togafitiga CBT vaega e ono i ai le aoga i luga hyperactive oxytonergic polokalama.
Nofoaga, tagata lolomi, tausaga, lomiga, itulau
Nature Publishing Group, 2019. Vol. 44, itulau. 114-114
upu autu [i]
Oxytocin ma Vaisu, Fa'aletonu Fa'afeusuaiga, Togafitiga o Amio
National Category
Pharmacology ma Toxicology Neurosciences Psychiatry
Faʻamatalaga
URN: urn:nbn:se:umu:diva-168967ISI: 000509665600228OAI: oai:DiVA.org:umu-168967DiVA, id: diva2: 1420877
fono
Fonotaga Lona 58 Faaletausaga a le American-College-of-Neuropsychopharmacology (ACNP), DEC 08-11, 2019, Orlando, FL
Faaopoopo: 1
Fa'amatalaga o le Fonotaga: M71
Avanoa mai: 2020-04-01 Fausia: 2020-04-01 Fa'afouina mulimuli: 2020-04-01
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