Neuropsychopharmacology. 2017 Ian 4. doi: 10.1038/npp.2017.1.
Kuiper LB1,2, Frohmader KS3,4, Coolen LM1,3,4.
lē faʻatino
O le faʻaaogaina o le psychostimulants e masani ona fesoʻotaʻi ma le hypersexuality, ma o tagata faʻaoga psychostimulant ua latou iloa aʻafiaga o fualaau faasaina i amioga faʻafeusuaiga o se mafuaaga mo le faʻaaogaina atili. Na fa'aalia muamua o le methamphetamine (Meth), pe a tu'uina fa'atasi ma amioga fa'afeusuaiga o lo'o fa'aalia ai le fa'aletonu o le taofiofia o amioga fa'afeusuaiga i se fa'ata'ita'iga fa'afeusuaiga (CSA) fa'ata'ita'iga e fa'atasi ai ma le ma'i. O se fa'ailoga lea o amioga fa'afeusuaiga leaga pe a mae'a le Meth ma le fa'afeusuaiga.
O suʻesuʻega o loʻo i ai nei na suʻesuʻeina ai ala neura na faʻagaoioia i le taimi o le taofiofia o amioga faʻafeusuaiga ma aʻafiaga o Meth faʻatasi ma amioga faʻafeusuaiga i luga o le neural gaioiga i nei auala, faʻaaogaina le ERK phosphorylation (pERK) e fai ma faʻailoga gaioiga.
Muamua, o le faʻaalia i faʻamaʻi faʻafefeteina i tamaʻitaʻi ua aʻoaʻoina e faʻalavelaveina amioga faʻafeusuaiga i le CSA paradigm na faʻaalia e faʻateleina ai le faʻaaliga pERK i le medial prefrontal (mPFC), orbitofrontal cortex (OFC) ma vaega i striatum ma amygdala..
Lona lua, o aʻafiaga o Meth faʻatasi ma feusuaʻiga na faʻataʻitaʻiina i tamaʻitaʻi na faʻaalia i le 4 i aso taʻitasi o Meth (1 mg / kg) poʻo le saline ma le mating ma faʻaalia i le CSA i le vaiaso e tasi pe a maeʻa togafitiga mulimuli. Meth ma mating-treated male na faʻaalia le faʻaleagaina tele i le taofiofia o le faʻaipoipo, maualuga le faʻaaliga o le pERK i lalo o tulaga faʻavae, ma faʻalavelaveina le faʻaogaina o le pERK e ala i le faʻaalia i le faʻalavelave faʻafefe i le mPFC ma le OFC.
Suiga o le pERK sa i totonu o le CaMKII-faʻaalia neu, faʻaalia suiga i faʻaaliga o nei vaega. Faʻatasi, o nei faʻamatalaga o loʻo faʻaalia ai o le Meth faʻatasi ma le faʻalavelave faʻafuaseʻi e mafua ai amioga faʻafeusuaiga leaga e fesoʻotaʻi ma suiga i le faʻagaioiina o neural i le mPFC ma le OFC.
PMID: 28051103
FAIA: 10.1038 / npp.2017.1
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