ʻO J Psychopharmacol. 2004 Dec;18(4):544-52.
ʻO Franken IH1, Hulstijn KP, Stam CJ, Hendriks VM, ka van den Brink W.
Hōʻuluʻulu Manaʻo
ʻO ka makemake no ka kokela kokahi kekahi o nā hiʻohiʻona nui o ka honu kokō. ʻO kekahi o nā pilikia me ka makemake e pili ana i ka ʻike. Nā kūlohelohe psychophysiological maʻamau e like me ka mālama ʻana o ka ʻili a me ka puʻuwai puʻuwai i lawe i nā hopena kūʻē kipi. Ua ʻike ʻia kēia mau ʻano o ke akeʻai e hoʻomaʻamaʻa wale ʻia me ka pīʻāpā ponoʻī ʻana i ka manaʻo ponoʻī. I ka noiʻi ʻana i kēia manawa, loiloi ka pili o ka lolo e pili ana i ka hanana (ERP) a me ka pane startle cue modulated (CMSR) i loiloi ʻia he indices for caineving caineving. I iwakāluakūmākahi mau poʻe mālama koko i hoʻokaʻawale ʻia i loko o nā pūʻulu haʻahaʻa kiʻekiʻe a haʻahaʻa e pili ana i ke kuʻina median o nā moʻoʻōlelo hōʻike ponoʻī. Huina ʻia nā ERPs a me CMSR i ke nānā ʻana o nā kumuhana i nā haʻalulu, maikaʻi, ʻoluʻolu a me nā kiʻi e pili ana i ka cocaine. Ma ka holoʻokoʻa, ua ʻike ʻia e hōʻike ʻia ana nā kumuhana e pili ana i ka koko i nā neʻe lohi ʻana (SPWs) o ka ERP ma nā kiʻi kokua i hoʻohālikelike ʻia i nā kiʻi kūlike. ʻO nā pua nani wale nō i hōʻike nui i ka SPW ma nā caine kokoleka, e hōʻike ana i kahi hui ma waena o nā SPWs cue-elicited a me ka hōʻike pilikino kokoti. Ke hoʻohālikelike nei i nā kaha ERP, ʻaʻole i hoʻokaʻawale ka CMSR ma waena o nā kiʻi kokoti a me nā kiʻi hapa kūleʻa. Eia kekahi, ʻaʻohe mau ʻokoʻa ma waena o nā haʻahaʻa haʻahaʻa a me ke kiʻekiʻe o ka ana CMSR. Hōʻike nā hopena o kēia manawa i ka paradigm e huki ʻia ka mea i loaʻa i nā hopena i hoʻohiki ai i ka cra-elicited craving. Pono ka hoʻohana ʻana o ka mana ʻōloe hou no ka hoʻokolokolo hou.
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