Psychopharmacology (Berl). 2018 Jan; 235 (1): 23-35. doi: 10.1007 / s00213-017-4744-0. Epub 2017 Oct 30.
Di Ciano P1, Manvich DF2, Pushparaj A1, Gappasov A1, Hess EJ3, Weinshenker D2, Le Kapeka B4,5,6,7,8,9,10.
Hōʻuluʻulu Manaʻo
MAU RĀKAHI:
ʻO ka maʻi keʻake ma ka māhuahua he hopohopo pili nui, e like me ka ʻike ʻia e ia ma ka helu ʻana i kēia manawa he maʻi addictive i loko o ka DSM-5. Ua hōʻike nā hōʻike hōʻike hihia i ka hōʻemi ʻana o disulfiram i ka pili ʻana o ka pili pili i ka pili kanaka i nā kāne.
NĀ HANA HANA:
ʻO ke kumu o ke aʻo i kēia manawa ʻo ia ka hoʻoholo inā pili ka disulfiram i ka hana ma luna o kahi hana i ka kaila ʻoi, ʻo kahi mea koʻikoʻi o ka hana ʻoihana ʻo Iowa i nā kānaka, a inā he pili paha nā mea hoʻololi i nā dopamine a me / a me nā pae norepinephrine.
KANAKA:
Ua hoʻokele ʻia ʻo Ratsela disulfiram ma mua o ka hoʻāʻo ʻana i ka hana pili i ka kaole ʻoi aku ai ma mua o ka loiloi ʻana o ka pae dopamine a i ʻole norepinephrine pae i loko o ka home homogenates. Ua mahele ʻia ʻo Rats i loko o ka hana ʻano i ʻelua mau pūʻulu. Ua koho ʻo Rats i ka hui maikaʻi loa i ka hoʻolālā pono e ʻoi aku, a me nā kiʻi i ka pūʻulu suboptimal (kahi like ʻole i ka pāʻani pilikia) i koho ʻo ia i ka hoʻolālā maikaʻi ʻole. ʻAʻole i hoʻokaʻawale ʻia ʻo Rats i nā lālā i hoʻoluʻu maikaʻi a suboptimal ma mua o ka loiloi neurochemical.
Nā hopena:
Hoʻokele ʻo Disulfiram iā 2 h, akā ʻaʻole 30 min, ma mua o ka hoʻomaʻamaʻa ʻana o ka hana mahele lāʻau i ka hoʻomaʻamaʻa maikaʻi ʻana i nāʻiole me kahi hoʻolālā maikaʻi ʻole "piliwaiwai" maikaʻi ʻole, ʻoiai he hopena ʻole i nāʻiole e hoʻohana ana i kahi hoʻolālā maikaʻi. Pili nā hopena a me nā hopena o ka disulfiram me ka nui o ka striatal dopamine a me ka hoʻemi ʻana i ka norepinephrine striatal.
NĀ KUMU:
Hōʻike kēia mau ʻike ʻana i nā hana i hoʻopili ʻia ma ka dopamine a me norepinephrine paha i lilo i mālama pono no nā maʻi kīleʻa.
KEYWORDS: Antabuse; Dopamine; Ke pāʻani nei; Norepinephrine
PMID: 29085979
PMCID: PMC5750121
DOI: 10.1007/s00213-017-4744-0
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