ʻO Biol Pākīpī. 2017 Jun 16. pii: S0006-3223 (17) 31672-4. doi: 10.1016 / j.biopsych.2017.06.010.
van Holst RJ1, Keleka G2, Janssen LK2, Janssen M3, Berry AS4, W O Jagust4, Hoʻopau i R5.
Hōʻuluʻulu Manaʻo
KEKAHI:
ʻO ka hypothesis e dopamine ka mea nui i ka pathophysiology o ka papa pathological i hoʻopōʻino ʻia. Eia naʻe, ʻaʻohe liʻiliʻi o ka hōʻike hōʻike pololei no ka hoʻokaʻawale ʻana ma waena o nā mea gambl pathological a me nā kumumana mālama i ke olakino e pili ana i ka lawe dopamine i kahi kūlana manuahi. Maanei mākou e hāʻawi ai i nā hōʻikeʻike no kēia hypothesis ma ka hoʻohālikelike ʻana i ka hiki ke dopamine synthesis i ka poʻe dorsal a me ka ventral o ka striatum ma 13 poʻe papaʻima papa a me 15 kumuhana olakino olakino.
KANAKA:
Ua loaʻa kēia18F] fluoro-levo-dihydroxyphenylalanine dinitron emission tomography scans a me nā wahi striatal o ka hoihoi i hoʻopili ʻia e pili ana i ka nānāʻana i nā hiʻohiʻona hoʻonaninani magnetic resonance imaging scan.
Nā hopena:
Hōʻike kā mākou mau hopena i hoʻonui ʻia ke kaha syntop dopamine i ka poʻe papa ukali pathological i hoʻohālikelike ʻia me nā kumuhana hoʻomalu olakino. ʻOi aku ka nui o ka syntrop Dopamine ma 16% kiʻekiʻe loa i ke kino caudate, ʻo 17% kiʻekiʻe loa i ka damenal putamen, a ʻo 17% kiʻekiʻe loa i ka striatum ventral i nā mea papa pololi i hoʻohālikelike ʻia me nā kumuhana paʻa. Eia kekahi, hiki i ka dopamine synthesis kaha i ka damenal putamen a me ke poʻo caudate me ka maikaʻi o ka launa pū ʻana me nā mea kolo i nā poʻe pāʻani āpau.
NĀ KUMU:
Lawe pū ʻia kēia mau hualoaʻa i nā hōʻike empirical no ka nui o ka synthesis dopamine synthesis i ka pāʻani pathological.
KEYWORDS: Ke kuikahi; Dopamine; Ke pāʻani nei; Neuroimaging; Uiho; [(18) F] DOPA
PMID: 28728675
DOI: 10.1016 / j.biopsych.2017.06.010
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