Hoʻohui Biol. 2016 Jan 5. hana: 10.1111 / adb.12338.
Liu L1, Yip SW2,3, Zhang JT4,5, ʻO Wang LJ4, Shen ZJ1, Liu B4, Ma SS4, Yao YW4, ʻO Fang XY1.
Hōʻuluʻulu Manaʻo
ʻO nā haʻawina i hana ʻia i ka ulia ʻana i ka lāʻau lapaʻau e hōʻike nei i kahi ka hoʻololi ʻana i nā hōʻiliʻili o nā lāʻau lapaʻau e pili ana i ka ventral i ka dorsal singa o ka striatum. Eia naʻe, ʻaʻole i aʻo ʻia kēia kaʻina hana i kahi hoʻohui kolohe. ʻO ka loiloi o kēia kaʻina hana i ka hoʻohui lāʻau ʻole hiki ke hāʻawi i ka ʻike i ka pathophysiology o ka waiwai a me nā hoʻohui. He kanakolu kumamāiwa ʻenekini huakaʻi pāʻani honua (IGD) a me 23 male ʻona hoʻomalu kūpono (HCs) i komo i ka hana me ka hoʻonaninani (magnetic resonance) i ka wā e hana ana i kahi hana cue-reactivity e pili pū ana i nā hōʻike e pili ana i ka hōʻeuʻeu ʻana o ka pāʻani pūnaewele pili i ka hoʻokolohua (cues game) a me ka Pūnaewele holomua. hoʻāliʻi ʻia e pili ana i ka hoʻouluulu ʻana. Hoʻohālikelike ʻia nā hana neue cue i loko o ka ventral a me ka dorsal striatum (DS) ma waena o nā mea hui o IGD a me HC. Ua ʻike ʻia nā hui ma waena o ka cue-reactivity ma waena o kēia mau ʻāina a me nā cue-induced craving a me ke koʻikoʻi a me ka lōʻihi o ka IGD. Ua hōʻike ka poʻe komo ʻo IGD i nā kiʻekiʻe e pili ana i nā hana cue-hoʻemi ʻia i loko o ka lua ventral a me DS a i hoʻohālikelike ʻia me HC. I loko o ka pūʻulu IGD, hana i loko o ka ʻaoʻao hema o ka ventral striatum (VS) i hoʻopale ʻia me ka cue-induced craving; Loaʻa nā hui maikaʻi ma waena o nā hana i loko o ka DS (putamen pololei, pallidum a me caudate hema) a me ka lōʻihi o ka IGD. Hoʻokomo ʻia nā hana cue i loko o nā pihi hema hema i nā kī VS ʻokoʻa ma waena o nā mea hui a IGD. Kūlike me nā haʻawina i nā mea pili i ke koina, ke hōʻike nei ko mākou mau hopena i kahi neʻe mai ka ventral i ka hana striatal dorsal e hele mai i waena o nā poʻe me ka IGD, kahi ʻano ʻole o ka hopena o ka waiwai komo.
KEYWORDS:
Pūnaewele ʻO ka pāʻani pūnaewele; cue-kamaliu; dorsal striatum; fMRI; ventral striatum
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