ʻO Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 27: 109680. doi: 10.1016 / j.pnpbp.2019.109680.
Kim H1, Kim YK2, Lee JY3, Choi AR3, Kim DJ4, Choi JS5.
Hōʻuluʻulu Manaʻo
Ua lilo ka haunaele ma ka pāʻani pūnaewele (IGD) i ke kumuhana o ka hopohopo e like me ke ʻano he hana hoʻohālikelike a ua hoʻohālikelike ʻia me ka waiwai me nā mea pili ʻole. ʻOiai ʻo IGD e hōʻike nei i nā mea ʻino a me nā hana kīwī, i ka hoʻololi ʻana o ka neurobiological ma IGD akā ʻaʻole i wehewehe ʻia ka maikaʻi. Ua hoʻohana mākou 18ʻO F-fluorodeoxyglucose PET e nānā i nā ʻokoʻa i ka metabolism glucose a me ka hoʻokūkū metabolic i nā kānaka ʻōpio [kanakolukumamāono mau maʻi me ka IGD, iwakāluakumāono ʻeono mau mea maʻi me ka maʻi ʻaluna (AUD) a me kanakolukumamāiwa mau mana olakino (HC)]. Ke hoʻohālikelike nei me ka HC, hōʻike ʻo IGD i ka hypometabolism ma ka cortex cinglima kūloko (ACC) mua, kūlohelohe, mua, parietal a me ka striatum a me ka hōʻike AUD e hōʻike ana i ka hypometabolism ma ka limipital, kino a me ka lobetal parietal. Eia kekahi, hōʻike ʻo IGD i nā loulou maikaʻi ma waena o ka ACC a me ka lōʻihi o ka pāʻani a ma waena o ka cortex orbitofrontal a me ka impulsivity. A no laila, loaʻa nō ka IGD ma ka liʻiliʻi o ka hoʻokūkū metabolic ma waena o nā wahi kino a me ka limu a ma waena o ka wahi me ka wahi o ka motor me ka rehiyon occipital. A hōʻike ʻo AUD i ka hoʻomohala ʻokoʻa nui ma waena o nā ʻāina orbitofrontal a me ka parietal, a ma waena o nā wahi o somatosensory a parietal a me nā wahi kūloko, akā ka lalo o ka hoʻoneʻe metabolic i nā wahi fronto-striatal a i ʻole fronto-limbic. Hāʻawi ʻia kā mākou mau hopena i nā hōʻike e pili ana ka hypometabolism a me ka hoʻoliʻi metabolic hoʻohui i loko o ka IGD e pili ana i ka hana naʻau sensn e ke kahe ʻana o ka pāʻani lōʻihi a me ka hoʻoiho ʻana i nā ʻāina hoʻokaumaha / hoʻoikaika.
KEYWORDS: Hoʻohālikelike ka hoʻohana ʻana i ka lāʻau hānai; Hoʻopili i nā pākia; Pūnaewele ʻO ka pāʻani pūnaewele; ʻO ka ʻike hoʻi o ka metabola; ʻO ka mana o ka wā Positron
PMID: 31255649
;