ʻO ka manaʻo lapaʻau. 2018 Apr 10; 9: 125. doi: 10.3389 / fpsyt.2018.00125. eCollection 2018.
Hong JS1, Kim SM1, Paola S2, Han DH1.
ʻO ka Oihana 1 o Psychiatry, Chung-Ang University Hospital, Seoul, South Korea.
ʻO 2 Pūnaewele Hoʻonaʻauao Hoʻonaʻauao Hui Pū ʻIa, Chung-Ang University, Seoul, South Korea.
Hōʻuluʻulu Manaʻo
Kūleʻa pinepine ka pāʻani pāʻani pāʻani pūnaewele i ka manawa a me nā mea nui i ke kaumaha (MDD). ʻIke ʻia ka kaumaha ma kahi kokoke me ka hakahaka hana uʻi (FC) i loko (a ma waena o ka ʻano maʻamau mode network (DMN) a me ka salience ʻoihana. Eia kekahi, hiki i ka serotonergic neurotransmission ke hoʻoponopono i nā hōʻailona o ke kaumaha, me ka impulsivity, hiki i ka hoʻololi ʻana i ka DMN. Ua hypothesized mākou i hoʻololi i ka pilina ma waena o ka DMN a me ka network salience hiki ke hoʻopili i kahi hui ma waena o ka 5HTTLPR genotype a me ka impulsivity i nā maʻi me ke kaumaha. ʻO ka nui o nā poʻe komo 54 me ka pāʻani pāʻani pāʻani ʻo ka pūnaewele a me MDD i hoʻopau i ka protocol noiʻi. Ua genotyped mākou no 5HTTLPR a loiloi i ka DMN FC e hoʻohana ana i ka hoʻomaha ʻana i kahi kūlana hoʻomaha malona. ʻO ka hōʻeha o ka pāʻani pāʻani Pūnaewele, hōʻeha i ke kaumaha, hopohopo, nānā a me ka impulsivity, a me ka hōʻino ʻana a me ka hoʻōho ʻana i loiloi me ka hoʻohana ʻana i ka hoʻohana ʻana i ka World Internet Addiction Scale (YIAS), Beck Depressive Inventory, Beck An depression Inventory (BAI), ʻĀina Hōʻīweliweli Hoʻomaopopo Hyperactivity Disorder scale , a me nā ʻano hoʻonaninani ʻano hana a me nā ʻano hoʻonaninani (BIS-BAS), kekahi. Ua pili pū ka SS allele me ka hoʻonui ʻia o ka FC i loko o ka DMN, me ka cortex prefrontal cortex waena (MPFC) i ka cortex posterior cing cortex, a i loko o ka salience network, a me ka hui o ka gyrus supramarginal kūpono (SMG) i ka pono rostral prefrontal cortex (RPFC). anular insular pololei (AInsular) a pololei SMG, ka cortex anterior cortex (ACC) i haʻalele iā RPFC, a waiho iā AInsular a pololei i ka RPFC, a ma waena o ka DMN a me ka hana salience, me ka MPFC a i ka ACC. Eia kekahi, ʻo FC mai ka MPFC a ACC i hoʻopili maikaʻi ʻia me nā helu BIS a me YIAS ma ka hui SS allele. ʻO SS allele o 5HTTLPR paha e hoʻololi i ka FC i loko a ma waena o ka DMN a me ka network salience, ka mea hope loa he hopena pili i ka pāʻani ʻana o ka pāʻani Internet i loko o nā mea maʻi me MDD.
KEYWORDS:
Pūnaewele ʻO ka pāʻani pūnaewele; ʻōnaehana paʻa mode; pilikia koʻikoʻi; kiko kiko; gen serotonin transporter
PMID: 29692741
PMCID: PMC5902486
DOI: 10.3389 / fpsyt.2018.00125
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