J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Mar 23; 1114-1115: 119-124. doi: 10.1016 / j.jchromb.2019.03.027.
Lee CW1, Lee D2, Lee EM1, Park SJ1, Ji DY1, Lee DY3, ʻO Jung YC4.
Hōʻuluʻulu Manaʻo
Hoʻohālikelike ʻia ʻoihana Pūnaewele Pūnaewele (IGD) e ka pāʻani leʻaleʻa ʻole a hoʻomau ʻana o nā pāʻani pūnaewele me ka loaʻa ʻole o nā hopena maikaʻi ʻole. ʻOiai aia kahi koi lapaʻau ma ka honua holoʻokoʻa, ʻaʻohe biomarker maopopo o IGD. ʻO ka pahuhopu nui o ke aʻo ʻana e hōʻike i nā pilikino lipidomic kikoʻī i ka maʻi pāʻani pūnaewele (IGD) e pili ana i ka wai-chromatography Orbitrap mass-spectrometry (LC Orbitrap MS). ʻO ka mea nui, he 19 lipids i kau nui ʻia i ka hui IGD i hoʻohālikelike ʻia i nā kaohi olakino. ʻO ka hiʻohiʻona lipidomic ka mea nui e nā ʻano like ʻole o nā phosphatidylcholines (PC) a me nā lyso-phosphatidylcholines (LysoPCs). Ma hope o ka hoʻohālikelike helu helu multivariate a me ka hoʻohālikelike regression linear i hoʻonoho mua ʻia i ʻelua LysoPCs (C16: 0 a me C18: 0) no ka biomarker hiki. Ua hōʻike ka loiloi e hoʻohana ana i ke ʻano hana (ROC) i ka hana maikaʻi loa o ka lipid hui ʻia no ka hoʻokae ʻana i ka hui IGD mai nā kaohi olakino (AUC: 0.981, 95% manawa hilinaʻi: 0.958-1.000). ʻO ka loiloi hou aʻe me nā mea hoʻohoka kūpono a me nā kikoʻī o ke olakino i ʻōlelo ʻia i ka ikaika a me ka hiki ke hoʻohana ʻia o ka hopena ma ke ʻano he biomarkers i hiki ke kōkua i ke kuhi.
KEYWORDS: Pākuʻi Pūnaewele Pūnaewele (IGD); Lipidomics; Kūlana chromatography; Lyso-phosphatidylcholine; Orbitrap mass-spectrometry (LC-Orbitrap MS)
PMID: 30951964
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