J Addict Med. 2012 Jun 20.
Montag C, Kirsch P, Sauer C, Markett S, Reuter M.
kahi
Mai ke Keʻena Psychology (CM, SM, MR), Laboratory of Neurogenetics (CM, SM, MR), a me Center for Economics & Neuroscience (CM, SMM, MR), Kulanui o Bonn, Bonn, Kelemānia; a me ke Keʻena Psychical Clinical (PK, CS), Central Institute of Mental Health, Lapaʻau Kula ʻo Mannheim, Heidelberg University, Mannheim, Kelemānia.
Hōʻuluʻulu Manaʻo
ʻO nā noi hou mai ʻAsia ua hāʻawi aku i nā hōʻike mua no kahi pilina molekole ma waena o ka serotonergic a me ka dopaminergic neurotransmission a me ka hoʻohui honua. Hāʻawi ka lono i kēia manawa i nā ʻikepili e pili ana i ka huina wai hou no ka noiʻi ʻana i ka hoʻohui i ka pūnaewele-ke kumu o ka gen coding no ka nicotinic acetylcholine receptor subunit alpha 4 (CHRNA4). Ua lawe ʻia kahi hoʻokolokolo hihia. Ua lawe ʻia nā mea hou mai kahi waihona hōʻaiola nui nui, me nā kānaka mai ka lehulehu a mai ke kahua o ke kulanui. Ka nui o nā helu 132 me ka pilikia pilikia o ka hoʻohana pūnaewele a me ka 132 makahiki a me nā mana o nā kāne i komo i ke aʻo ʻana. Hāʻawi nā mea komo i nā tauira DNA a hoʻopiha i loko o ka nīnau nīnau no ka mea e hōʻole i ka pūnaewele. Ua hele pinepine ka hōʻike T- variant (CC genotype) o ka polXorphism rs1044396 ma ka huaʻa CHRNA4. Ua hōʻike hou ʻia nā hōʻike ʻokoʻa hou i kēia hopena. ^ E Ha yM. Hoʻohui ʻia me nā ʻike mai nā haʻawina ʻē aʻe, ka ʻikepili o kēia manawa i ke ala e hōʻike ai ka rs1044396 i nā hopena pleiotropic i ka nui o nā ʻano, me ka nānā ʻana, ʻuhane a me ka hoʻohui.
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