Hoʻohālikelike i ka hana ma mua o fronto-limbic i ka hui pūʻana i nā mea hana hewa i nā keiki (2019)

Hōʻuluʻulu Manaʻo

kāʻei kua

keiki hoʻopilikia a ua pili ʻole ka haʻalele ʻana i ka nui o ka neʻe no ka hoʻomohala ʻana i ke ʻano o ka nui o ka hana, ka noʻonoʻo ʻana a me nā nā pilikia pilina a me ka nui o ka huina s lawehala. Ma ka likeʻole i ka nui o ka noiʻi e nānā ana i nā hopena hopena maikaʻiʻole o ka hoʻopiʻi keiki, akā,ʻaʻoleʻike ikiʻia e pili ana i keʻano o ke keiki nā moe kolohe a me nā waihona neuronal e hāpai ana i ka'ōpiopio i ke kolohe.

Nāʻano a me nā hiʻohiʻona

Ke nānā nei kēiaʻokoʻa i kaʻokoʻa kūlana hoʻomaha hoʻopili paʻa ʻana (rs-FC) ma waena o nā lawena lawaiʻa non-pedophilic (N = 20; CSO-P) a me nā mana olakino olakino (N = 20; HC) e hoʻohana ana i kahi ʻano pili lāʻau. ʻO ke kiko o kēia noiʻi o rs-FC i CSO-P ua kau i luna o nā wahi prefrontal a me limbic i kūpono loa no ka hoʻoulu ʻana i ka manaʻo a me ke ʻano hana.

Results

Hōʻike nā hualoaʻa i kahi hōʻemi nui o rs-FC ma waena o ka centromedial kūpono amygdala a hema ka hema ke kūkākūkā mua i nā keiki lawehala i hoʻohālikelike ʻia i nā kaohi.

Hopena & ʻōlelo paipai

Hāʻawi ʻia, i ka lolo olakino, aia kahi ikaika ma luna o lalo control pale o ka prefrontal ma luna o nā hana limbic, i hōʻike kēia mau hopena i ka hōʻemi rs-FC ma waena o ka amygdala a me ka cortex prefrontal cortex dorsolateral a hiki ke hāpai i ka hana kolohe a me ka moekolohe. ʻO kahi ʻike hohonu o kēia mau manaʻo e pono ai i kahi ʻike ʻoi loa ka hanana ʻana o ka hewa kolohe o ke keiki, a me ka hoʻomohala hou aʻe o nā ʻokoʻa ʻē aʻe a kūpono maikaʻi.

Keywords

Hoʻopiʻi maikaʻi aku i ke keiki

Ka hōʻino ʻana o ke keiki

Kūlana hoʻomaha

Hoʻohui paʻa

Hoʻohālikelike kahe hana mana (fMRI)

1. Introduction

He ʻeha ākea ka hewa o nā keiki (CSO) e pili ana i nā miliona o nā keiki a puni ka honua, ʻoiai ua haʻi aku ka United Nations i nā kuleana o ke keiki, ma 1989, i ka Helu 19 a me 34, e pale ai i ke keiki hoʻopilikia (Barth et al., 2013; Stoltenborgh et al., 2011). ʻO nā hewa hewa o nā keiki i waena o nā lawehala e hoʻonāukiuki i ka hopohopo nui a puni ka lehulehu ma o nā lehulehu, hoʻomana, a me nā hui socioeconomic. Ma muli o nā hopena olakino pōkole a me ka lōʻihi ka maʻi hōʻeuʻeu post-traumatic (PTSD) i nā kaumaha a me nā kaumaha, a me ka hoʻonui pū ʻana s lawehala (Hornor, 2010; Joiner et al., 2007). Nā kumuhana ākea ākea-manaʻo e manaʻo nei ka laulima ākea o ka hōʻino kino ʻana o nā keiki hana (CSA) ma mua o 10% (Pereda et al., 2009; Stoltenborgh et al., 2011). Ma kahi o 3% o nā keikikāne a me 9% o nā kaikamāhine ua pāwī o ka hōʻino kino a me ka moekolohe.Finkelhor et al., 2014; Häuser et al., 2011). ʻOiai ʻo kēia mau pālahalaha nui a me ka manaʻo nui e pale i kēia mau hewa, ʻike iki ka pili e pili ana i ka hoʻomakeke ʻana o ka CSobi a me nā mākaʻi e alakaʻi ana iā CSO (Kärgel et al., 2015). Oiai pedofilia ka mea i ʻike ʻo ia ka mea koʻikoʻi nui no ka hana ʻana ma CSO, ʻaʻole lawa a pedophilia a ʻaʻole pono no CSO (Seto, 2008; Seto et al., 2006). Ke hōʻike nei nā hoʻokūkū ma waena o ka mea hoʻomāinoino i nā kāne lawehala e pili ana i ka 50% o nā hewa a pau e hana ʻia ana e CSO non-pedophilic.ʻO Maletzky lāua ʻo Steinhauser, 2002). ʻO nā mea helu pono, ʻo ia ka pono o ka pihi, i kēia manawa aia nā manaʻo e pili ana i ka nui o ka makemake ʻole o ka CSO, no ka mea ʻaʻole i hōʻike ʻia ka hapa nui o CSO (Hanson et al., 1999). Wahi a Blanchard et al. (2006), hana hewa loa i ka hewa i nā kamaliʻi e nā lawehala non-pedophilic. Hoʻokomo nui kēia mau hewa i ka hoʻoweliweli a hoʻopilikia i ka hoʻohālikelike ʻana i nā mea hoʻokele pedophilic (Kingston et al., 2007). Hōʻalo ʻia nā haʻawina e pili ana i nā hana kīʻaha o CSO i ka poʻe neʻe me ka makemake ʻole o ka male ʻana i nā keiki. Ka hana kolohe hiki paha ma muli o nā hopena paʻakikīThakker a me Ward, 2012). He hana ʻino ma ka laulā (Davidson et al., 2000), a me ke ʻano hoʻomāinoino i ka pilikino (Howells et al., 2004; Ward a me Beech, 2006), kū pinepine e like me ka hopena o ka hoʻoponopono lohi i nā manaʻo manaʻo (Gillespie et al., 2012; Langton a me Marshall, 2000; ʻO Ward a me Hudson, 2000). Eia kekahi, ke ʻano nui o ke ʻano kākau puke i ke kīnā ʻole i ke kīnā ʻole i ke hoʻoponopono i nā kīʻaha maikaʻi i hoʻopili ʻia e lilo i kumu kumu i ka hana kolohe o ka moe kolohe (ʻO Hanson lāua ʻo Harris, 2000).

I ka pae neural, aʻo nā loiloi e pili ana i ka hana olakino i ʻike i ka pili ʻana o nā hana limu, i ka ʻokoʻa amygdala a me ka ka hana kino mua (PFC) koʻikoʻi i ka hoʻoponopono pono o ka ʻuhane.Davidson et al., 2000; Dörfel et al., 2014; Gillespie et al., 2012; Lee et al., 2012; Paschke et al., 2016) a ʻano hanaBeauregard et al., 2001; Georgiadis a me Kringelbach, 2012; Klucken et al., 2016; Stoléru et al., 2012). Ua kuhi ʻia ʻo ia ka PFC e hōʻoia i ka naʻau ʻeuʻeu a me ke kūlohelohe a me ka maʻi kūloko a me ka hopena.Kärgel et al., 2015; Rosenbloom et al., 2012) akā, ʻaʻole maopopo loa ka hana kikoʻī o nā ʻano prefrontal ʻokoʻa. Ua kākoʻo ʻia ka hana o ka amygdala ma ke ʻano he kikowaena o ka ʻuhane a me ke ʻano kūlohelohe ma o nā haʻawina e hoʻopili ana i kāna hana e hana i ka ʻuhane ʻōpala.ʻO Etkin lāua ʻo Wager, 2007; Kamphausen et al., 2013) a me ka hoʻonaninua (Baird et al., 2004; Mohnke et al., 2014; Schiltz et al., 2007; Walter et al., 2008), a me ke kala hewa (Kärgel et al., 2015; Poeppl et al., 2014). ʻAʻole kahi hale homogous i ka amygdala, akā he hui paʻakikī i hoʻokumu ʻia i ʻekolu sububitions nui: he basolateral, he superficial, a he centromedial complex, nā mea o ke kikowaena a me ke kūloko medial (CMA; Amunts et al., 2005; Roy et al., 2009). He hana koʻikoʻi ka CMA i ka kuhikuhi ʻana i nā pane pane.Ko et al., 2015) e nā mea hoʻomalu i ka oʻanā a me nā ʻāpana cortical a striatal (ʻO Davis, 1997; Roy et al., 2009), ke komo ʻana i nā hana moʻo i wahine (Gillespie et al., 2012). Kūʻē kekahi poʻe noiʻi nui i ka hana nui o ka nucleial medial i ka kāohi o ka hana reproduction (Dominguez et al., 2001; Kondo, 1992; Newman, 1999). Ke kākoʻo nei nā hōʻike hōʻike i ka hana koʻikoʻi no ka CMA i ka hana i kuhikuhi ʻia i nā makana (Parker et al., 2014; Robinson et al., 2014) e like me ka mea hana. Eia kekahi, hui nui ka CMA i ka hypothalamus, no ka mea ke hoʻokūkū nui nei hoʻi i ka kuhikuhi ʻana i nā mea pili ʻole i ka moekolohe (Poeppl et al., 2015) ke ʻano ikaikaFalkner me Lin, 2014). Eia kekahi, Beauregard et al. (2001) ua manaʻo ʻia he mea koʻikoʻi nā amygdala i ka hoʻololi ʻana o nā pane endocrine a me autonomic ma o nā kuhi ʻana mai CMA a i ka hypothalamus. Ua kūʻē nā kumu hou i pili i ka hoʻololi ʻana o ka hana CMA hoʻoponopono hui nā hemahema i nā kānaka me nā kiʻekiʻe o nā hiʻohiʻona psychopathic (Moul et al., 2012).). Ma kahi kikoʻī, ua hoʻohālikelike ʻia ka hana limahana a me ka hoʻopili ʻana ma waena o ka amygdala a me ka PFC. noʻonoʻo noʻonoʻo (Motzkin et al., 2011).). E pili ana i nā pae ʻāina anatomical (Öngür et al., 2003) a me ke kiko o ka hana (Hanaʻia, 2004), nā kūpono pili ʻāina komo i ka hoʻoponopono kānāwai. Hiki i ka nui ke hoʻokaʻawale i ka orbitofrontal (OFC), nā dorsolateral (dlPFC), ka ventrolateral a me ka PFC medial. ʻOiai nā hōʻike ʻike loiloi anatomical i hōʻike i ka pilina pili kūlohelohe ma waena o ka amygdala a me ka OFC, ka ventrolateral PFC a me ka dorsomedial PFC (Ghashghaei et al., 2007), nā dlPFC e hoʻohana i kona mana nui ma luna o nā hana limahana kūʻokoʻa ma ke kū pono ʻole ma o ka OFC (Gillespie et al., 2012; Phillips et al., 2008).). Hoʻomaopopo kēia mau ʻāina i ka hana nui no ka kaohi o nā mea kolohe ʻano, ka hana a me nā ʻano.Beauregard et al., 2001; Leon-Carrion et al., 2006; Toates, 2009) me ka hoʻoulu kaua paʻa (Davidson et al., 2000).). ʻO ka cortex orbitofrontal cortex (OFC) ka noho i ka ʻaoʻao o ka mahele o ka ʻaoʻao mua o ka lolo ma ka ʻokoʻa o ka ʻōpū o ka lolo (Fuster, 1997).). Ke hoʻokō nei ka OFC i ka mea nui i ka hoʻoponopono pili naʻau. Ua hoʻopuka nā liona ma ka OFC a me nā wahi ʻo PFC i pili i ka syndromes i hōʻailona ʻia e ke ʻano ka pulunaele a me ka ʻaihue (no ka ʻike hou aku e ʻike Nā Rolls, 2004). (Gillespie et al., 2012) i wehewehe i ka mea nui o ka OFC i ka hoʻomaopopo ʻana i ka hui ʻana o ka hoʻoponopono o ka manaʻo a me ka cognition ma muli o ka pilina ikaika o ka amygdala. ʻO ka OFC a me nā mea pili e pili ana i ka pilina, ʻo ia hoʻi ka amygdala. Hoʻohui ka pilina mai nā wahi o ka cortex prefrontal, ʻoi aku paha i ka OFC, i ka amygdala i manaʻo ʻia no ka mea e hana ʻia ana i ke kino kūmau,Davidson et al., 2000) a me ke ʻano o ka hana ʻuhane (Schmidt et al., 2017). Stoléru et al. (2012), i hoʻoponopono ʻia i ka OFC e like me ka mea nui loa no ka pehi ʻana i ka moekolohe a me ka maʻi hypghesala, OFC a me PFC medial, a i ʻole substrate neural o ka moʻau wahine. I Georgiadis lāua ʻo Kringelbach (2012), nā amygdala a me ka orbital a me ventromedial nā cortards pili me ka makemake a me ka moekolohe excitation. ^ E Ha yM. Nā Hoʻololi o ka hoʻopili paʻa ʻana ma waena o OFC a me amygdala i loaʻa nō hoʻi ma CSO (Kärgel et al., 2015).). ʻO ke kuleana o ka dlPFC i ka kaohi o ka hoʻokō e hoʻomau nei i ke kumuhana o ka hoʻokūkū mau.ʻO Mars a me Grol, 2007) Aia ka dlPFC i loko o ka ka mua lobe a pili pū me ka cognitive ka mana hana (Baena et al., 2010) a kū i ka mea nui Nā wahi a Brodmann 9 a ʻo 46 akā 8-9, 9-45, 46-10, a me 46 – 45 (ʻO Rajkowska a me Goldman-Rakic, 1995 no kahi ike; Miller a me Cohen, 2001).). Ua pili pinepine ʻia me ka mālama wale ʻana o ka ʻike i ka nānā ʻana i ka ʻike pili kūloko o nā hoʻihoʻi naʻau a me nā hoʻolālā kaʻa (ʻO Curtis lāua ʻo DʻEsposito, 2003) a ua manaʻo e hāpai i ka hoʻoponopono ʻana o ka naʻau ma o ke kaʻina hana o ka reappraisal (Golkar et al., 2012), A ʻōpiopio alakaʻi (Ballard et al., 2011). Akā pili pū kekahi i ka hoʻokau wahine (Beauregard et al., 2001; Leon-Carrion et al., 2006), ka moekolohe (Schmidt et al., 2017) a me ka impulsivity (Ko et al., 2015; ʻO lāua ʻo Raine, 2009) ma ke ala e kau ai i ka hoʻokele hoʻokele e pili ana i ka ʻano hoʻoikaika a me ka ʻuhane.Delgado et al., 2008) Lee et al. (2012) ua ʻike he kūpono ka pilina (fc) ma waena o dlPFC a me amygdala, i pili pono no ka hoʻoponopono ʻana i ka manaʻo maikaʻi ʻole, a ma ke ʻano he kumu kumu no ka hewa kolohe (Ward, 2014). Ma ka laina me kēia mau ʻike, ua hoʻopili ka pili o ka pilina ma waena o dlPFC a me amygdala me ka nui o ka hopohopo no ka hana ʻino (Davidson et al., 2000), halihali (Ko et al., 2015) ke ʻano hanana hypersexual (Schmidt et al., 2017), nā hewa kolohe loaʻaʻole (Poeppl et al., 2013), nā pōʻino koʻikoʻi i ka hoʻoponopono lula, a me ka hoʻoulu kaua ʻana (Hou et al., 2007). No laila ke kumu nui o ka amygdala i ka ʻikepili i nā manaʻo i ka wā o ka hana o ka PFC o ka mālama i ka hopena o ka amygdala. Hōʻike nā pilikia o ka hoʻoponopono naʻau i mea e hōʻeha i ka CSO.

ʻO ka hapa nui o nā haʻawina e pili ana i ka hoʻokau hewa ʻana o ke keiki e mālama ʻia ana i nā lawehala pedophilic a he nui nā haʻawina i helu ʻole i nā hopena o ka lawehala a me ka makemake kolohe. Ke hōʻike nei kahi ʻano ulu kino i ka CSO ma mua o ka pedophilia, e pili ana i ka hemahema o ka hana hoʻokūkū a me ka hoʻoponopono o nā naʻau.Kärgel et al., 2016, 2015; Poeppl et al., 2013). No laila, noiʻi kēia noiʻi e noiʻi kūlana hoʻomaha ka hana hāmeʻa paʻa ma ke keʻena ʻoi aku ka loiloi ʻana i ke keiki ʻole-pedophilic nā moe kolohe i loko o ka ʻoihana amygdala, kūpono nui loa no ka hoʻoponopono ʻana i ka manaʻo, ka ʻano, a me ka wahine hoʻi. Maikaʻi mākou i nā ʻokoʻa i ka hoʻopili hoʻohui ʻana ma waena o ka laugdala a me nā wahi i loko o ka cortex prefrontal e pili ana i ka hoʻoponopono kānāwai. Ke kuhi nei kēia noiʻi e hāʻawi i kahi ʻike ʻoi loa o ka pilina ma waena o ka hana hoʻomohala aberrant a me ka hoʻonaninani kūlohelohe, a me ka hoʻolaha ʻana i ka pale pale a me ka hopena therapeutic i CSO.

2. Nā Papahana

2.1. Nā mea komo

ʻIkuhi ʻia nā mea komo i loko o ka pānaʻi noiʻi noiʻi ʻana i kahi Kelemania i kapa ʻia ʻo "Neural Mechanism under under Pedophilia a me ka Hewa kolohe i nā keiki ”(NeMUP; www.nemup.de). Mai ka huina holoʻokoʻa NeMUP o nā mea i ʻike ʻia ma mua o 400, ʻo ka ʻikepili mai nā kumuhana non-pedophilic i mālama i ke keiki hoʻopilikia loiloi ma Hannover Medical School and Essen University Hospital (CSO-P, N = 20) a me nā mana olakino maʻamau (HC, N = 20) i hoʻohālikelike ʻia me ka mahalo i ka makahiki, IQ, hāʻawi lima, a ke kauā ua hui ʻia (1 Pūnaewele). Hoʻokipa ʻia nā ʻikepili i nā hoʻohālike mai kēia mau pūnaewele, ʻo ka mea i loaʻa iā ia nā ʻikepili ma kahi 3T Skyra MRT, a ua lawe ʻia ka nui o nā kumuhana CSO-P ma laila. No ka hoʻopaʻa ʻana i nā mea hoʻokūkū kūpono, hoʻohālikelike ʻia nā hui e pili ana i ka hana pili ʻana i ka wahine. nā moekolohe a ʻo ka ulu ʻana (Pākuʻi S1, S2 & S3). ^ E Ha yM. Ua lawe ʻia nā kumuhana me kahi mōʻaukala o CSO mai nā hoʻoponopono hoʻoponopono. Ua wehewehe ʻia kahi mōʻaukala o CSO ma ke komo ʻana o ka poʻe ma kahi liʻiliʻi ma kahi liʻiliʻi o ka CSO no nā keiki liʻiliʻi ma lalo o ka makahiki 14, ka mea e komo ai i nā hana o ke komo ʻana i ke keiki a me ka maʻi vaginally me ka pahuhopu hoʻonaninani iā ​​lākou iho. ʻO nā pākuʻi puka nā maʻi psychiatric loiloi i loko nā nīnau kūkala semi-hoʻonohonoho (SKID; Wittchen et al., 1997), nā hanana ʻeha o ka waiʻona a i ka hōʻino ʻana i ka lāʻau lapaʻau / hilinaʻi, a me nā lāʻau lapaʻau i kēia manawa e pili ana i ka hana pilikino a i ʻole ka maʻi ʻana o ka pedophilia. ʻAʻole kekahi o nā mea i komo psychotropic lāʻau lapaʻau no ka manawa o ka liʻiliʻi ma 3 mau pule ma mua o ka loiloi. Ua hoʻihoʻi ʻia nā mana olakino mai ke kaiāulu ma o ka hoʻolaha ʻana i nā ʻoihana aupuni. Ua ʻae ʻia ka noiʻi e ke komite ʻenehana o kēlā me kēia papa noiʻi ʻokoʻa. Hāʻawi ka poʻe hoa āpau i ʻae ʻia i ʻae ʻia i ka pepa noiʻi ma mua o ka hoʻokomo ʻia ʻana a loaʻa ka uku kālā no ko lākou komo ʻana.

ʻ Xlelo 1. ʻO keʻano o nā hui aʻo.

lepe kiʻi: Poloaʻi i ka loiloi ʻia me ka hoʻohana ʻana i kahi mana 10-mea hoʻohui ʻia o ka German Edinburgh Handedness Inventory. Hōʻī ʻia nā helu naʻauao mai nā subtests ʻehā o ka hopena pōkole o ka Kelemania WAIS ke hoʻohana nei i kēia ʻanoʻatikala:hua'ōlelo) + nā helu pālākiō (mea like)] * 3.0 + [nā helu pālākiō (poloka hoʻolālā) + nā helu pālākiō (kumu kumu)) * 2.5. ʻO ka ʻokoʻa ma waena o nā hui i loiloi ma ke ʻano he ʻelua-hōʻike t-ʻoi loa. Abbr .: CSO-P = non-pedophiles me ka mōʻaukala o ke keiki hele hewa. ^ E Ha yM. HC = ola palekana. r = pololei, l = hema, amb = ambidextrous. SD = loʻea kūlike. N = helu o nā kumuhana i ka hui.

2.2. ʻO ka loiloi loiloi a me nā nīnau no ka noʻonoʻo

Ma kēia noiʻi, pili mākou i ka hui ʻana o nā hewa pili i ka lawehala me ka psychopathology a me nā kaʻina hana e ʻike i ka hoʻowalewale ʻia. hewa ʻole. ^ E Ha yM. No laila, no nā kikoʻī, ua hoʻokomo mākou i kēia mau nīnau a me nā semi-i hoʻonohonoho ʻia nā kūkākūkā kalepa: DSM-IV-TR ʻO Axis I (SCID I) a me Axis II (SCID II; Fydrich et al., 1997; Wittchen et al., 1997; Lake 2 Pūnaewele); Palapala Kahiko Skale Kūʻai (HAM-D; Hamilton, 1996b); ʻO ka Haili Loʻo i ka Hamilton ʻona (HAM-A; Hamilton, 1996a); Nīnau nīnau trauma keiki kāne (CTQ; Bernstein a me Fink, 1998); Barrat huakai lahui (BIS; ʻO Patton et al., 1995); a me ka Wender Utah Rating Scale no ka Hōʻeuʻeu Haumaha Hoʻoikaika (ADHD) no nā pākeke (Homburger ADHD unahi (HASE); Rösler et al., 2008; Lake 3 Pūnaewele). Ua mālama ʻia ka hoʻākāka ʻokoʻa ʻana o nā hana hoʻohālikelike o ka rs-FC a me nā ʻano noʻonoʻo. Ua hoʻokō ʻia nā loiloi āpau ma waena o nā mea noiʻi ʻike loea, mākaukau e hoʻohana i kēia mau mea hana. I ka lua lua, MRI loiloi ua hana ʻia me ke ana ʻana i ka hana a me ke ana ʻana. ʻAʻole i loaʻa nā CTQ, BIS a me ADHD data no ka ʻelua o nā kumumana hoʻomalu. ʻAʻole i loaʻa nā ʻike ADHD no kahi o nā kumuhana CSO. Hōʻike ʻia ka hewa a me nā hiʻona i nā kikoʻī i ka Hoʻohui S1.

Pakuhi 2. Nā maʻi axis Psychiatric-I a me nā maʻi axis-II ma ke kumu o ka nīnauele SKID I & II.

'Ōlelo Aʻo. ʻO CSO-P = mau nonoho ʻole me ka mōʻaukala o ke keiki hele hewa; HC = ola palekana; N = helu o nā kumuhana i ka hui; OR = mau palena o ka lā / RR = pili i ka pilikia; ʻO ka ʻokoʻa ma waena o nā hui i loiloi e hoʻohana ʻia Hoʻolaha-Exact-test.

ʻ Xlelo 3. Nā maʻi maʻi o ke kumu.

'Ōlelo Aʻo. CSO-P = keiki pili hewa me ka makemake ʻole o ka pedophilic; HC = ka palekana olakino; N = helu o nā kumuhana i ka hui; SD = loʻea kūlike. ʻO ka ʻokoʻa ma waena o nā hui i loiloi ma ke ʻano he ʻelua-hōʻike t-test.

2.3. Neuroimaging

Ua kiʻi ʻia nā kiʻi āpau ma ʻelua mau pūʻulu 3T Siemens Skyra MRI, hoʻokahi ma Hannover a hoʻokahi hoʻi ma Essen, i hoʻopiha ʻia me nā coil kanaluna 32. Ke kāohi nei i ka holo ʻana o nā hōʻailona ma waena o nā pūnaewele ʻelua, ua ʻae ʻia nā hanana kaulike MRI Phantom.Hellerbach et al., 2013). Ma hope o ka loaʻa ʻana o kahi kiʻi T1 kūkulu, hana nā mea komo i kahi scan fMRI mokuʻāina hoʻomaha me ka lōʻihi o 11 min. Ua aʻo ʻia i nā mea komo e moe mālie, e paʻa mau nā maka, a hele auwana i ko lākou noʻonoʻo. Loaʻa nā kiʻi Structural T1 ma o ke kaʻina MPRAGE (ʻoki = 192, FoV = 256 mm, nui voxel = 1 × 1 × 1 mm, TR = 2.5 s, TE = 4.37 ms, ʻoki kikowaena = 7 °, helu mamao = 50%). Loaʻa nā kiʻi T2 * hana keu me ka hoʻohana ʻana i an Imaging planar imaging (EPI) kaʻina (ʻāpana = 38, kahua ʻike = 240 mm, ka nui o ka voxel = 2.3 × 2.3 × 3 mm, ka nui o nā puke = 275, ka manawa o ka hana hou = 2.4 s, manawa kuʻi = 30 ms, ʻaoʻao kūwāhi = 80 ° , helu mamao = 10%).

2.4. Ka ʻikepili ʻana i ka ʻikepili

Kuhi ʻia nā ʻikepili me ka hoʻohana ʻana i ka SPM 8 (Welina Hope Center no Neuroimaging, Lākana, ʻEnelani) a me DPABI 2.3 (Song et al., 2011; Yan et al., 2016). Ua hahai nā ʻōkuhi preprocessing i ka protocol maʻamau i hōʻike ʻia e nā mea kākau o luna. Ua hoʻoneʻe ʻia nā kiʻi ʻelima mua i ka mooolelo no ka hiki ʻole o ka hōʻailona mua a me ka hoʻololi ʻana o nā kumuhana i ka scanner. Ua hoʻopau ʻia nā kiʻi a i hoʻoponopono ʻia i ke kiʻi ʻano e hoʻoponopono no ka neʻe ʻana. ʻAʻohe kumuhana i hōʻike neʻe o ke poʻo ʻoi aku ka nui ma mua o ka 3 mm i ka unuhi a i ʻole ka nui ma mua o ka 3 ° i ka pala. Ua hoʻomaʻamaʻa ʻia nā kiʻi i ke kahua staiotaxic Neurological Institute (MNI).Collins et al., 1998) me ka hoʻohana ʻana hoʻokaʻawale i ke kiʻi T1 (Ashburner lāua ʻo Friston, 2005) a hoʻopi ʻia i 3 × 3 × 3 mm³. ^ E Ha yM. Hoʻopau ʻia nā kumu kumu o nā hōʻailona pono ʻole (Weissenbacher et al., 2009), e like me nā nuisance covariates, me nā kiko kikoʻī (12) kikoʻī ʻĀkau nui (Satterthwaite et al., 2013; Yan et al., 2013); ka mea keʻokeʻo hōʻailona; a ka wai o ka maʻi hōʻailona. Eia kekahi, ua hōʻano hou ka hōʻailona honua i ke ʻano o ke kaʻina hana nei e hāpai i ka holomua o ke kikoʻī o hoʻopili paʻa ʻana (Fox et al., 2009) a hiki ke hoʻomaikaʻi i ka hoʻoponopono ʻana i nā kiʻi artifact (Yan et al., 2013). Loaʻa ʻia nā kiʻi hualoaʻa a hoʻonaninani kūwali ʻia (0.01-0.08 Hz).

Ke noʻonoʻo nei i ke ʻano o ka hoʻopili ʻana i nā hana i maʻalahi i ka neʻe iki ʻana o ke poʻo, ua alakaʻi mākou i kahi kaʻina scrubbing neʻe e ka lawe ʻana i nā scans me kahi paepae hoʻokalakupua (FWD) o> 0.4 mm, e like me ka wehewehe ʻana Jenkinson et al. (2002). Ma hope o ka holoi ʻana, mālama ʻia nā kumuhana āpau> 50% mau helu manawa. ʻAʻohe ʻokoʻa ʻokoʻa (p> .05) ma FWD o nā helu manawa i koe i loaʻa ma waena o CSO a me HC i nā ʻikepili ʻelua. Ma mua ʻikepili helu, ke kiʻi nei i nā kiʻi me kahi kāmele Gaussian o 6 × 6 × 6 mm³ (piha piha ma ka hapalua lōʻihi).

2.5. ʻIkeʻikepili

Ka helu ikepili a me ke koho ROI: I mea e hoʻoponopono ai i waena o nā ʻokoʻa o ka hui amygdala uʻi ʻili pūnaewele pili ʻana, ua koho ʻia ka amygdala hema a me ka ʻākau no ROIs no ke ʻano loiloi. Ma keʻano pilikino, ʻo ka ʻāpana sentromedial (CMA) o ka amygdala hema a me ka ʻākau hoʻi he priori i wehewehe ʻia he ʻano hua (Laau. 1) a huki ʻia mai ka pahu pahu hana Anatomy (Eickhoff et al., 2007; 2006, 2005; Qin et al., 2014), ma muli o ko lākou koʻikoʻi koʻikoʻi i ka hoʻoponopono hui nā hemahema (Moul et al., 2012), kuhikuhi ana i nā pane pane (ʻO Davis, 1997; Roy et al., 2009), a ke hoʻonohonoho ʻana i nā moekolohe (Gillespie et al., 2012). I mea e kiʻi ai i ka pilina hana, ʻo Pearson's Koʻolau ʻoihana a he lulu ma waena o lā pūnaewele o nā hua amygdala a me ke kaʻina manawa o nā voxel āpau i ka lolo. E helu no ka maʻamau helu, helu ʻia nā coefficients hoʻopili e ka Fisher Z-loli. Ua hoʻohana ʻia kēia mau ʻōuli i hoʻololi ʻia no ke kumu hoʻohālike 1st ma SPM 8. Ma kahi hōʻike loea 2nd, ka makahiki, ka pūnaewele, a me IQ i hoʻokomo ʻia ma covariates i loko o ka manaʻo hoʻohālike. A hopena pālua i ʻelua-hōʻike tUa hana ʻia nā hana ma waena o nā hui i kēlā me kēia kanaka Z-values ​​ma ke ʻano leo-ʻina e hoʻoholo i ka wahi lolo ka hōʻike ʻana i nāʻokoʻa like ʻole o ka hui ma waena o ka amygdala a me nā leo'ē aʻe i loko o ka ʻoihana ʻo amygdala. Hōʻalo i ka loiloi olakino (Kriegeskorte et al., 2009) i kapa ʻia ʻo "luʻu lua" ʻana o ka pūnaewele amygdala i unuhi ʻia mai kahi mana kūʻokoʻa o 30 mau mana olakino i hoʻohana ʻole ʻia i kēia kālailai akā ana ʻia me nā kūmole MRI like. Ua wehewehe mākou i ka pūnaewele amygdala i ka wā hoʻomaha e like me nā voxels e hōʻike ana i nā pilina koʻikoʻi me ka amygdala, p <0.05 (uncorrected), i ka laʻana holoʻokoʻa. No kēlā me kēia kumuhana, ua hoʻohana ʻia ka pūnaewele amygdala ma ke ʻano he mask no ka nānā ʻana i ka ʻāpana-hoihoi (ROI) (p <0.05, ua hoʻoponopono ʻia kahi leo liʻiliʻi no nā hoʻohālikelike he nui i loko o ka pūnaewele amygdala holoʻokoʻa, e ʻike. Laau. 1) ma waena o nā hui (Poldrack, 2007; Worsley et al., 1996).

1. Hoʻoiho i ke kiʻi kumu kiʻekiʻe (297KB)
2. Hoʻoiho i ke kiʻi piha

XiraU 1. Ma waena o nā hui ʻokoʻa i kūlana hoʻomaha hoʻopili paʻa ʻana (rs-FC) o ka hema (A) a me ka'ākau (B) CMA (p <0.05, FWE hoʻoponopono ma ka pae cluster): ʻAʻohe mea ʻokoʻa i ka rs-FC ma waena o nā hui i ʻike ʻia me ka hoʻohana hema. amygdala ma ke ʻano kahiki (A). Ua hōʻike nui ʻia ka CSO-P i ka hoʻohuihui haʻahaʻa haʻahaʻa ma waena o CMA kūpono a me ka dlPFC (C). ua kau ʻia nā ʻokoʻa rs-fc ma luna o ka wahi MNI maʻamau UAAIIeIA. ^ E Ha yM. Nā pakuhi Bar e hōʻike ana i nā helu Z i kēlā me kēia hui no dlPFC (D). Abbr. Hōʻike naʻauao ʻo MNI Montreal Neurological Institute FWE ʻĀpana pololei CMA = pololei centromedial amygdala. ʻO CSO-P = mau nonoho ʻole me ka mōʻaukala o ke keiki hele hewa. ^ E Ha yM. HC = ola palekana. rs-FC: hoʻomaha ʻana i ka hoʻohana ʻana i nā hoʻopili lawelawe.

Ua manaʻo ʻia nā hualoaʻa he mea nui e hoʻohana ana i ka hewa ʻohana p <0.05 (FWE), i hoʻoponopono ʻia no nā hoʻohālikelike he nui ma kahi pae pae.

2.6. ʻO ka nānā ʻana

Ua hana ʻia nā loiloi post-hoc i SPSS v 24 (IBM Inc.) me ka hoʻohālikelike ʻana i nā kumumanaʻo hoʻokahi kumumanaʻo (CEs) o nā waiwai o ka Persona. Kuhi ʻia kēia mau waiwai mai kahi mai, e hōʻike ana i nā ʻokoʻa ma waena o nā pūʻulu o FC (ʻo ka pihi voxel mai nā koʻi MNI ma −24, 18, −51 (dlPFC; hua ROI: pololei CMA)) me ka hana o ka papa hana SPM8. Hoʻopili ʻia nā CE me nā psychometric a me nā ana hoʻokolohua (ADHD, HAM-A, CTQ, a me BIS). Ua manaʻo ʻia he pilina ʻo Pearson o p <0.05 he mea nui.

3. Results

3.1. Nā kiʻi Demokalika a me nā lāʻau lapaʻau

O ke keiki pili hewa hui (CSO-P) nui i nā helu kiʻekiʻe ma nā nīnau no nā keiki he ʻelima no ka wā kamaliʻi (CTQ).3 Pūnaewele). Ua piʻi aʻe kahi kiʻekiʻe o ka hopohopo (p <0.05) a me nā ʻōuli e pili ana i ke kaumaha (p <0.01) e like me HAM-A a me HAM-D, a me nā helu kiʻekiʻe o nā maʻi pilikino (Mann-Whitney-U. = .015), a me nā maʻi axis psychi-one i hala (p = <.001) (2 Pūnaewele). ʻAʻohe ʻano koʻikoʻi o nā hōʻailona o ka ADHD ma waena o CSO-P a me nā mana olakino (HC). Eia nō naʻe, hōʻike ka hoʻohālikelike hui i ka ʻokoʻa nui i nā helu WURS-K, ke hōʻike nei i nā hōʻailona ADHD i ka wā kamaliʻi ma nā keiki ʻauhau kamaliʻi (11 mau kanaka me kahi ʻoki ʻokiʻoki i ʻike ʻia ma mua o 30 e hōʻike ana i ka ADHD i kona wā kamaliʻi; 2 ma waena o nā mana olakino a me 9 ma waena o CSO- P). ʻAʻohe meaʻokoʻa i loko ka pulunaele e like me ka Pākuʻi Barratt-impulsiveness (BIS).

3.2. Hoʻohui paʻa

ʻO nā hoʻohālikelike o nā hui i hōʻike nui ʻia kūlana hoʻomaha hoʻopili paʻa ʻana (rs-FC) i loko o ka amygdala kikowaena i CSO-P ma waena o ka amygdala centromedial kūpono (CMA) a me ka hema ke kūkākūkā mua (dlPFC) (4 Pūnaewele & Laau. 1). Ua māhele ʻia ka hapa nui o ke pua i waenakonu PFC aʻo 24 voxels i hoʻolauna ʻia i loko o ka PFC maikaʻi loa e pili ana i ka hōʻailona kuʻina ʻomi ʻili (AAL; Tzourio-Mazoyer et al., 2002). ʻAʻole ʻokoʻa kahi o ka fc ma waena o CMA hema a me nā kāpili o ka lolo i loaʻa ma CSO-P i hoʻohālikelike ʻia me HC. ʻAʻohe hui nui ma waena o ka pono rs-FC a psychometric nā hana e komo ai ka CTQ, HAM-A, HAM-D, ADHS, a i ʻole BIS. Eia kekahi, ʻo ka hopena o ke koʻi o ka axis-I me ka wehe ʻana o ka pūʻulu (i ʻole a i ʻole, ʻehaʻeha, a i ʻole, ʻaʻole i ʻae ʻia / ʻae ʻole) i hoʻokaʻawale i ka hoʻohālikelike ʻana i nā kuhi kikoʻina o ka cll dlPFC i ka pō holoʻokoʻa a ma nā ʻāpana like ʻole. ʻokoʻa ka hoʻohana ʻana i ka hōʻike ʻole ʻaʻole parametric. ^ E Ha yM. ʻAʻole i ʻike ʻia nā hoʻoponopono pili nui.

ʻ Xlelo 4. Nā hōʻailona koʻikoʻi i ka RS-FC ma waena o ke keiki non-pedophilic nā moe kolohe a me ka palekana olakino.

Hoʻomaopopo. CMA = centro medial amygdala; MNI = Ke Kahua Neurological Montreal; dlPFC = ke kūkākūkā mua; L = waiho. r = pololei. ʻO ka ʻokoʻa ma waena o nā hui i loiloi ma ke ʻano he ʻelua-hōʻike nā ho'āʻo. ^ E Ha yM. Ua hoʻoponopono ʻia nā hopena no nā hoʻohālikelike he nui i hoʻohana ʻia nā helu hewa o ka ʻohana a ua palena ʻia i ka ʻoihana amygdala.

4. kūkākūkā

I ko mākou ʻike, ʻo ia ka noiʻi mua ʻana e noiʻi i nā loli i loko ka hoʻopili ʻana o ka lolo hoʻomaha ma kahi kikoʻi maʻamau o ke keiki non-pedophilic nā moe kolohe ua hoʻohālikelike ʻia i nā koina olakino maikaʻi. Hōʻike nā hualoaʻa i nā hōʻike no ka hoʻoneʻe ʻana o ka pilina hana ma waena o CMA ʻākau a me ka dlPFC hema, i ke keiki lawehala e hoʻohālikelike ʻia i nā mana olakino ʻole ʻole. ʻAʻole ʻike ʻia nā hopena i ka makahiki, IQ, hāʻawi lima, a ke kauā a ʻaʻole i pili i ke kaumaha, ka hopohopo, nā ʻokoʻa hoʻāla i nā wā kamaliʻi, ka pulunaele, nā mākaʻikaʻi o nā kauka ADHD, a i ʻole ʻo ka ulu ʻana nā mea, e like me ka hoʻomaka ʻana o ka masturbation, ejaculation, coitus, a i ʻole ka helu o TSO a i ʻole nā ​​hoa hana. Hāʻawi ʻia ka pilina o ka fronto-limbic i hōʻike ʻia e ka ʻohana ākea e hōʻike ana i ka hana pono ʻole o nā hana prefrontal a me subortical i hoʻopili ʻia i nā ʻano like ʻole. hewa ʻole (ea Birbaumer et al., 2005; Contreras-Rodríguez et al., 2015; Joyal et al., 2007; Kiehl et al., 2001; Raine et al., 1997; ʻO lāua ʻo Raine, 2009). ʻOiai he kānalua paha nā loli maʻamau i ka limu a me / a i ʻole ke hoʻonohonoho ʻana i mua o ka prefrontal e pili pono i ka moekolohe.Joyal et al., 2007), aia nā ʻikepili empirical e hōʻike ana i kahi kikowaena o ka dorsolateral mahele o ka ka hana kino mua a me ka amygdala i ka hoʻoponopono ʻana i nā manaʻo (Lee et al., 2012) a ʻano hanaSchmidt et al., 2017). Hoʻomaopopo ʻia kēia mau wahi e komo i ka hewa lawaiʻa keiki.Kärgel et al., 2015; Mohnke et al., 2014; Poeppl et al., 2013) a me ka moekolohe kūae paha ma muli o ka pilina ikaika i ka OFC (Gillespie et al., 2012) akā, koi hou aku noiʻi. Hoʻopau i ka pili pono ʻana ma waena o nā hana limbic a me ka prefrontal kinoha, aia pū me ka amygdala a me ka cortex orbitofrontal e hoʻonui i loko o nā ʻāpana dorsolateral, i hōʻike mua ʻia ma kahi hōʻike o ka hana ʻino ʻana i nā pedophiles e hoʻohālikelike ai i nā kīkala lau ʻole hoʻohālikelike a me nā mana olakino (Kärgel et al., 2015). Kākoʻo kā mākou ʻike i ke kuhi o ka noiʻi mua e hiki ke kipaku ʻia kēia hopena e ka lawehala moekolohe keiki ma mua o ke alo o kahi makemake pedophilic wale. ʻOkoʻa iā Kärgel a me nā hoapili (Kärgel et al., 2015), Ua lele ʻo Poeppl a me nā hoa hana i ka hoʻololi kino ʻana o ka dlPFC hema a me ka amygdala ʻākau he pedofilia-kiko, a pākuʻi ʻia nā hanana laulā he mea nui no ka hoʻoulu ʻana i ka moekolohe ma o ka hoʻopilikia ʻana i ka loiloi ʻana i ka manaʻo a me ka hiki ʻole o ka miscategorization o nā keiki e like me ka mooolelo (Poeppl et al., 2015). Eia nō naʻe, i ka noʻonoʻo ʻana i nā haʻawina e hoʻokele pono ana a hoʻokaʻawale i nā hopena o CSO a me ka makemake pedophilic, makemake ʻia kekahi e pili ana i ka hui ʻana ma waena o ka dlPFC a me ka amygdala e like me ka hana hana i kikoʻī no ka lawehala hewa, ma mua o ka makemake pilikino (Kärgel et al., 2015). I kēia hihia, e pili pono ka makemake o ka wahine i ke koho ʻana i nā mea hōʻeha.

Hōʻike ka ʻike o ka wā o ka wā a me mua paha i ka nui o ka interplay ma waena o nā hana prefrontal a me limbic - ʻo ia hoʻi, ka pilina huakaʻi - no ka cognitive, motivational, a me ka hoʻoikaika ʻana i ka hana ma ka wā o ke kaʻina hana hōʻino a me / a me nā manaʻo i loko o ka hana hewa ʻana o ke keiki.Cunningham a me Brosch, 2012; Janak me Tye, 2015; Kärgel et al., 2015; Poeppl et al., 2013). Pono ke ʻano kūpono o ka moe kolohe i ke kūkulu ʻana i ka ʻikepili pili pono me ka lawa pono pono hoʻokolokolo (Massau et al., 2017), a he pono e hoʻoponopono ʻia ma o nā mea hoʻomehana i alakaʻi ʻia e nā kūkulu prefrontal. ʻOiai wale nō, Kärgel et al. (2016) hōʻike ʻia o ke kūlana maikaʻi loa control pale i nā pelophile ʻole CSO i ka wā i hoʻohālikelike ʻia i nā pedophiles me CSO a me nā palekana olakino, e like me ka hōʻike ʻana o nā haʻahaʻa haʻahaʻa na hala o ke komisina a me ka hoʻonui hou ʻana i ka hema Nā huahele cingulate a waiho ʻia he cortex mua i mua o kahi paradigm GoNogo. No laila, nā ʻike hou, me ka noiʻi o kēia manawa, hiki ke hoʻomau hou i ke kumumanaʻo o ka fronto-limbic functioning (Cohen et al., 2002; Kärgel et al., 2015; ʻO Poeppl a me Nitschke, 2013; Walter et al., 2007; Ward, 2014) he kumu kumu kūpono paha no ka moekolohe o ke keiki kūʻokoʻa i ka hanana ʻana o kahi makemake pedophilic. ʻOiai ʻo OFC, lateral PFC a me ka dorsomedial PFC e pili pū ana i ka amygdala - ke ala pehea o ka dlPFC e hoʻopuka ai i kona mana i ka hoʻoponopono ʻana i ka moe kolohe a me ka hewa.Mohnke et al., 2014; Phillips et al., 2008). E pili ana i nā ʻike pili e pili ana i ka pili ʻana a me ka hoʻopili pono ʻana o ka Amygdala, he mea kupanaha loa, ʻaʻole ʻike mākou i ka hoʻololi pono ʻana o ka hoʻohui ʻana i ka OFC a me ka ventromedial PFC. ʻOiai ʻo nā noiʻi hou i hōʻike aku ai i ka pili ʻana i nā pilina anatomical ma waena o ka amygdala a me ka dlPFC (Bracht et al., 2009) i ka manaʻo o kekahi ua kūpono ka pilina hope loa o ka OFC no ka pale o ka pale ʻana i ka hoʻolālā o nā limu.Delgado et al., 2008; Phillips et al., 2008; Nā Rolls, 2004) ʻO ke kūpono o ka pili ʻana o ka loaʻa ʻana he mea kikoʻī. ʻOiai ʻo ka huaʻāina PFC i ʻike ʻia ʻaʻole wale ka waena o ka PFC wale nō a ʻo ka PFC cortex maikaʻi loa ka mea i ʻike ʻia he kumu koʻikoʻi no ka mālama pono ʻana i ka hanana amioga.Kärgel et al., 2016) ʻaʻole i hoʻopili pono ʻia ka FC i nā ana i ka impulsivity i lawe ʻia mai BIS, ADHS-SB a me WURS-K. I ka ʻike ʻole ʻana i ka pilina me ka impulsivity, hiki i kahi ke kuhi ke ʻae nā pili o ka lawelawe ʻana i nā ʻoihana hoʻokūkū kiʻekiʻe. hana hoʻomanaʻo, hoʻonohonoho neʻe), kahi pili me ka pili ke kūkākūkā mua kūlike Kūkā ʻia kekahi mau mea metodolo i kēia manawa. A hiki aku i nā hoʻokolokolo ʻana o nā hoʻoponopono hoʻoponopono i ka laulā maʻamau, a me nā manaʻo koʻikoʻi e like me ke ʻano o ka moe kolohe i ke ʻano, pono nā hopena noiʻi kūloko. Kūlana hoʻomaha ʻO ka hana hoʻopili honuʻo ia ke ʻano maʻalahi i ka loiloi a ʻaʻole i hoʻoweliweli maʻalahi ʻia, a no laila, e hoʻolako i kahi ala hoʻohiki no ka maʻi e hiki mai ana a me ka loiloi-loiloi ma CSO. ʻO ka hapa nui o nā noiʻi e noiʻi ana i nā hoʻololi ʻana o ka naʻau i ka lawena lawaiʻa keiki e lawaiʻa ana me ka hoʻohana ʻana i nā hiʻohiʻona o nā lawehala kolohe keiki, ka paʻakikī o ka hoʻokaʻawale. paraphilia a me nā hewa ʻole (Mohnke et al., 2014). No laila, ua pili mākou i nā lawehala lawehala non-pedophilic e hōʻoia i ka loaʻa ʻana o nā hewa kūikawā, e like me ka hypothesized i ka noiʻi mua (e la. Kärgel et al., 2015). Pono e noʻonoʻo hou i kēia pilikia i mālama a mālama pono i ko lākou hopena i ka makemake a me ke ʻano. ʻOiai ʻo ka pilikia nui ma ka wā o ka hoʻokipa ʻana a ke kūlana hoʻokolohua i nā mea i hoʻopaʻa ʻia ai, ua lanakila mākou i ka hoʻohālikelike ʻana i ka lehulehu lawehala koʻikoʻi a me ka lehulehu e pili ana i ka hale paʻahao. Ke hoʻokipa nei i nā mea hoʻokae kūpono e like me ka mea hiki, ua palena mākou i kā mākou noi ʻana i kekahi pūʻulu o nā lawehala hana keiki ʻole ʻole pedofilia a ʻaʻohe koʻokoʻo koʻokoʻo koʻikoʻi ka maʻi noʻonoʻo a i ka lāʻau ʻana paha psychopharmacological. Eia nō naʻe, ua piʻi ka kiʻekiʻe o CSO-P i nā kiʻekiʻe kiʻekiʻe o e ola kahi comorbidity kūlohelohe (e like me ke ʻano o nā helehelena pilikino), hiki ke lilo i kahi ʻāpana i ka paʻakikī etiology o ka hana ʻino. ʻAʻole hiki ke hoʻopaʻapaʻa ʻia ko mākou ʻike ʻana ʻaʻole maʻa i nā lawehala o nā keiki, akā no ka hoʻohālikelike ʻana i nā moekolohe kahi ʻano antisocial laulaha. ʻO ka mea hope loa, ke ʻano wale o ka noho ʻana i kahi hui hoʻoponopono e hiki ke loaʻa ka mana i ka hoʻopili pili pono a me ka noʻonoʻo maikaʻi (Kim, 2015). No ka hoʻopaʻa ʻana i ka paʻahao ma ke ʻano he confounder kūpono, pono ia e hoʻohālikelike i nā lawehala kolohe keiki mai ka mālamele i nā lawehala kolohe keiki. E ʻike i nā hopena i loaʻa i ka hewa a i ʻole pedophilia kikoʻī, ʻo ka hoʻolālā kūpono he hoʻolālā × 2 × 2 (CSO + P, P-CSO) e hōʻike ʻokoʻa i kēlā me kēia hanana. Pono e noʻonoʻo hou i kahi noiʻi hou. ʻO ka mea hope, makemake mākou e hoʻokākala i nā hopena o kā mākou ʻike no ka noiʻi i ka wā e hiki mai ana, a me ka hoʻomaikaʻi ʻana i nā ʻano therapeutic a me ka pale ʻana iā CSO. ʻAʻohe mea kānalua e pono nui nā ʻōnaehana lapaʻau kūpono no ka lawehala kolohe. He loiloi Cochrane ma ka lāʻau (Khan et al., 2015) a me ka noʻonoʻo noʻonoʻo i nā mea lawehala (Dennis et al., 2012) hopena ua hōʻike ʻole kahi hōʻike kūpono i nā hoʻolālā lapaʻau e hiki ke hōʻemi i ka hopena lōʻihi o ka hoʻihoʻi hou ʻana, no laila, pono kahi ʻano hana hou a pono kā lākou loiloi kūpono. Hāʻawi ʻia kā mākou mau ʻike i ka pili e pili ana i ka pilina o ka hoʻomaha ʻana i ka hoʻopili ʻana i ka hana, nā hoʻoponopono mua o nā hana limbic, a me ka hana hewa ʻana o ke keiki. ʻO kahi ala kūpono e mālama ai i ka poʻe lawehala, pono e kamaʻilio i kēia me ka hoʻokaʻao fronto-limbic FC, ma o nā ala therapeutic ʻano i ʻike ʻia e hoʻoikaika ai i kēia mau hana, therapy mālama-noʻonoʻo cognitive therapy (MBCT; Frewen et al., 2010) a me ke kaili pili nā kālaihana (Perez et al., 2016), ai ʻole ma nā ʻenehana kūpono e hoʻoikaika i kēia mau wahi ma o nā hana hōʻeuʻeu transcranial (tDCS; Gbadeyan et al., 2016; Padberg et al., 2017) ai ole ke kuhikuhi paha i ka manawa kikoʻī (fMRI)Paret et al., 2016).

5. Panina

I ka hōʻākāka, hōʻike kā mākou ʻike i ua hōʻemi hoʻopili paʻa ʻana ma waena o CMA hema a me ka dlPFC hema, he ʻāpana o ka nā kaila neurobiological i lalo o ka hana hewa a nā keiki. ʻO nā hemahema i ka hoʻopili hoʻohui ʻana o kēia mau mea e alakaʻi ai i ka mana o ka hanana ʻino. No laila, e nānā pono nā ʻano therapeutic e pili ana i hiki iā lākou ke hoʻoikaika i ka pilina pili ma waena o kēia mau hana. ʻO ka pīhoihoi ʻaʻole mākou i ʻike i ka launa huakaʻi paʻa a OFC a me ka ventrolateral a i ʻole ventromedial PFC. Pono ʻia ka noiʻi hou ʻana i ka mālamalama ma waena o ka naʻau a me ke alakaʻi, a hiki paha i ke kōkua maikaʻi ʻana i ka hoʻopaʻa ʻia ʻana o ka hanana kolohe hewa ʻole i ka laulā, a me nā moekolohe hewahewa pū kekahi, a me ka like ʻole a me ka like ʻole. kūpono maikaʻi.

Hōʻike manaʻo

Hōʻike nā mea kākau i ka makemake ʻole kūleʻa.

'Ōlelo hōʻeia

Ua mahalo ʻo nā mea kākau iā Agnès Bechinie, Kim Borchert a me Lisa Christoph no kā lākou kōkua i ka hoʻokumu ʻana i kēia kākau. ʻO kēia noiʻi he ʻāpana o ka papahana noiʻi multisite e pili ana i nā hana neural i lalo ma lalo pedofilia a me ka ʻeha ʻino i nā keiki (i kapa ʻia ʻo NeMUP), nā kālā a ka Federal Ministry of Education a and Research (BMBF): 01KR1205 i BS, MW, KMB, HW, JP a me THCK. Ua hoʻolako ʻia nā māhele o ke aʻo ʻana e ka German Research Foundation (DFG): ʻO Schi 1034 / 3-1 i BS.

Ka'Apili Hou A. Nāʻikepili hou

ʻO ka aʻe aʻe kahiʻikepili hoʻohui e pili ana i kēia ʻatikala:

Hoʻoiho i ka palapala ʻōlelo (15KB)Kōkua i nā faila docx

Papa ʻaina 1.

Hoʻoiho i ka palapala ʻōlelo (15KB)Kōkua i nā faila docx

Papa ʻaina 2.

Hoʻoiho i ka palapala ʻōlelo (16KB)Kōkua i nā faila docx

Papa ʻaina 3.

ʻIkepili noiʻi no kēia ʻatikala

Loaʻa nā ʻikepili i ʻole / ʻikepili e loaʻa i ka noi

E pili ana i ʻikepili noiʻi

E hoʻomaopopo '

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^☆

ʻO "NeMUP" ka huaʻikepili o kahi pūʻulu noiʻi Kelemania i kākoʻo ʻia e ka German Federal Ministry for Education and Research a kū no Neuronal Mechanism Uʻike Pka hana popoki a me ke kolohe.