Psychoneuroendocrinology. 2015 Nov; 61: 53. hana: 10.1016 / j.psyneuen.2015.07.534. ʻO Epub 2015 Aug 8.
Aʻo Chatzittofis A1, Hoʻopili S1, Öberg K1, Hallberg J1, Nordström P1, Jokinen J.
o ka Naauao
- ʻO nā kāne me ka maʻiʻehaʻeha uaʻoi aku ka kiʻekiʻe o ka DST ma muli o ka mana kīnā ma mua o nā mana.
- ʻO nā kāne me ka maʻi hōʻeha,ʻoi aʻe ka kiʻekiʻe o DST-ACTH mau kiʻekiʻe i ka hoʻohālikeʻana i nā mana.
Hōʻuluʻulu Manaʻo
ʻO ka maʻi o ka wahine e pili ana i nā maʻi pathophysiological e like me ka hoʻopiʻiʻana i ka wahine kāne, ka hoʻoponoponoʻana i ka wahine, ka ponoʻole, a me ka puʻupuʻu i'ōleloʻia no ka DSM-5. Eia naʻe,ʻaʻoleʻike ikiʻia e pili ana i ke neurobiology i hope o kēia maʻi. Ua hōʻikeʻia kahi'ākau o ka maʻi pituitary adreal (HPA) ma nā maʻi psychiatric akāʻaʻole iʻimiʻia i ka maʻi o ka wahine. ʻO ke kumu o kēia aʻoʻana,ʻo ia ka nānāʻana i ka hana o ka axis HPA i ka maʻiʻeha.
ʻO ka haʻawina e pili ana i nā maʻi male 67 me ka maʻiʻeha me ka 39 mau kōkua kōkua kāne ola. ʻO nā plasma o ka plasma kakahiaka o cortisol a me ACTH ua heluʻia a ua hanaʻia me ka cortisol ka mea liʻiliʻi (0.5 mg) a hanaʻo ACTH i ka hoʻoponopono post dexamethasone. Ua hoʻohālikelikeʻia ka mana kīnāʻole me nā kūlana DST-cortisol ≥138 nmol / l. Nā pākuʻi kaulike (SCS), ka helu helu maʻamau o ka maʻi maʻamau (HD: CAS), Montgomery-Åsberg Pahūʻana i ka helu heluʻana (MADRS-S) a me ka nīnau nīnau'ōpiopio (CTQ), no ka heluʻana i ka moe kolohe, ka pōpilikia o ke ola mua.
ʻO nā maʻi me ka maʻiʻehaʻeha he mea nui loa ka DST me nā mea kākoʻoʻole a uaʻoi aku ka kiʻekiʻe kiʻekiʻe o DST-ACTH mau mea i ka hoʻohālikeʻana i nā limahana olakino. Ua hōʻike pinepineʻia nā maʻi i keʻano o ka'ōhumu'ōpiopio a me nā hiʻohiʻona pōʻino e pili ana i nā limahana olakino. Nā helu CTQ i hōʻike i kahi pilikino maikaʻiʻole me DST-ACTH me ka SCS a me ka HD: Nā helu CAS i hōʻike i ka hoʻohalikeʻole me ka cortisol lālani i nā maʻi. ʻO ka hōʻailona o ka maʻiʻeha koko kahi i pili nui loa i ka DST ma ka hoʻopauʻana a me ka DST-ACTH plasma kiʻekiʻe ma ka manawa i hoʻoholoʻia no ka maʻi o ka'ōpiopio.
ʻO nā hualoaʻa e hōʻike ana i ka dysregulation axis HPA i nā kāne kāne me ka maʻiʻeha.
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