(REMISSION) Functional neural changes and altered cortical-subcortical connectivity associated with recovery from Internet gaming disorder (2019)

J Behav Addict. 2019 Dec 1;8(4):692-702. doi: 10.1556/2006.8.2019.75.

Dong GH1,2, Wang M1, Zhang J3, Du X4, Potenza MN5,6,7.



Although studies have suggested that individuals with Internet gaming disorder (IGD) may have impairments in cognitive functioning, the nature of the relationship is unclear given that the information is typically derived from cross-sectional studies.


Individuals with active IGD (n = 154) and those individuals no longer meeting criteria (n = 29) after 1 year were examined longitudinally using functional magnetic resonance imaging during performance of cue-craving tasks. Subjective responses and neural correlates were contrasted at study onset and at 1 year.


Subjects’ craving responses to gaming cues decreased significantly at 1 year relative to study onset. Decreased brain responses in the anterior cingulate cortex (ACC) and lentiform nucleus were observed at 1 year relative to onset. Significant positive correlations were observed between changes in brain activities in the lentiform nucleus and changes in self-reported cravings. Dynamic causal modeling analysis showed increased ACC-lentiform connectivity at 1 year relative to study onset.


After recovery from IGD, individuals appear less sensitive to gaming cues. This recovery may involve increased ACC-related control over lentiform-related motivations in the control over cravings. The extent to which cortical control over subcortical motivations may be targeted in treatments for IGD should be examined further.

KEYWORDS: Internet gaming disorder; anterior cingulate cortex; cue-craving task; longitudinal studies

PMID: 31891311

DOI: 10.1556/2006.8.2019.75


Internet gaming disorder (IGD) has been associated with significant impairments in social and personal functioning, poorly controlled craving (Kim et al., 2018), excessive time spent gaming (Dong, Zhou, & Zhao, 2010), poor academic achievement (Hawi, Samaha, & Griffiths, 2018), and other negative measures of health and functioning. IGD has been considered as an addictive disorder, and preliminary diagnostic criteria have been established in part based on another behavioral addiction, i.e., gambling disorder (Dowling, 2014; Petry, Rehbein, Ko, & O’Brien, 2015). The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) listed IGD as a “Condition for further study” (American Psychiatric Association, 2013). In May 2018, gaming disorder was adopted for inclusion in the 11th edition of the International Classification of Diseases (ICD-11; http://www.who.int/features/qa/gaming-disorder/en/), despite debates (Aarseth et al., 2017; King & Gaming Industry Response, 2018; Rumpf et al., 2018; Saunders et al., 2017).

During cue-craving tasks, IGD relative to control subjects have demonstrated greater attention to game-related cues (Choi et al., 2014), with prefrontal regions implicated (Ahn, Chung, & Kim, 2015). During executive tasks, IGD relative to control subjects has shown diminished executive control (Nuyens et al., 2016), with the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) implicated (Dong, Wang, Du, & Potenza, 2017, 2018; Dong, Wang, Wang, Du, & Potenza, 2019). During decision-making in IGD (Pawlikowski & Brand, 2011), the striatum and ACC have been implicated (Qi et al., 2016). In these and other studies, cross-sectional approaches comparing IGD and control groups have typically been employed, limiting an understanding of how changes in brain function may underlie transitions in IGD.

While cross-sectional studies may reveal brain features associated with IGD, they cannot distinguish whether brain alterations may precede the development of IGD, result from the gaming behaviors or be generated by other mechanisms. As such, longitudinal studies may help disentangle neural vulnerabilities from neural consequences. Additionally, and importantly from a clinical perspective, understanding brain changes related to recovery is important, and this may be achieved through longitudinal studies.

In behavioral addictions like gambling disorder, many individuals recover naturally (i.e., without formal intervention (Slutske, 2006; Slutske, Piasecki, Blaszczynski, & Martin, 2010). Like those with gambling disorder, many IGD individuals may recover without professional intervention (Lau, Wu, Gross, Cheng, & Lau, 2017). Estimates of remission range from 36.7% to 51.4% in IGD (Chang, Chiu, Lee, Chen, & Miao, 2014; Ko et al., 2014). Although potential factors (such as decreases in craving) for remission in IGD have been proposed (Chang et al., 2014; Ko et al., 2014, 2015), little is known regarding brain mechanisms underlying recovery processes in IGD.

In the current study, we investigated longitudinally a group of individuals with IGD. We used functional magnetic resonance imaging (fMRI) to scan IGD subjects at “baseline” and again after 1 year, with a focus on individuals who no longer met criteria for IGD. By comparing subjective and imaging data from individuals with active versus recovered IGD, we aimed to identify subjective and neural factors underlying recovery. This approach may provide insight into individual differences relating to resiliency and recovery and could potentially help with the development of more targeted and effective interventions.

Cue reactivity and craving in IGD

Craving to addiction-related cues reflects a strong motivation to engage in addictive behaviors. Craving may promote drug use (Sayette, 2016; Sinha & Li, 2007), gambling (Potenza et al., 2003), and gaming (Dong et al., 2017) in individuals with related disorders. Thus, craving has been a target of therapies for addictions (Potenza et al., 2013), as craving may shift attention toward addiction-related cues (Sayette, 2016; Tiffany, 1990), influence the evaluation of relevant information (Sayette, Schooler, & Reichle, 2010), and impair decision-making processes (Balodis & Potenza, 2015; Berridge & Kringelbach, 2015; Dong & Potenza, 2016). In addition, reexposure to drug-related cues may lead to strong cravings and drug-seeking behaviors in drug addictions (Gardner, McMillan, Raynor, Woolf, & Knapp, 2011). For the aforementioned reasons (including IGD’s classification as an addictive disorder), we focused on craving in this study of IGD.

Like drug cues in drug addictions, gaming cues may trigger game-seeking behaviors in IGD (Dong & Potenza, 2016). IGD participants have exhibited higher cue-induced brain features in the ventral and dorsal striatum (Liu et al., 2017), altered functional networks (Ko et al., 2013; Ma et al., 2019), higher late positive potential amplitude (Kim et al., 2018), when compared with control subjects when exposed to gaming cues. Neural responses to gaming cues may predict the emergence of IGD (Dong, Wang, Liu, et al., 2019) and operate in a gender-sensitive fashion (Dong, Wang, et al., 2018). Thus, we hypothesized that brain regions implicated in prior studies of craving (e.g., the striatum) would show less activation following recovery than during active IGD when subjects were exposed to gaming cues.

When individuals are exposed to gaming-related cues, cortical brain regions (e.g., the DLPFC and ACC) may exert control over subcortical brain regions (e.g., the striatum) in addictions such as in tobacco-smoking (Kober et al., 2010) and models of cognitive control generally (Bush, Luu, & Posner, 2000). Executive functions involve a set of processes necessary for cognitive control, including selection and monitoring of behaviors to facilitate achievement of chosen goals (Hall et al., 2017). Addictions have been associated with impaired inhibitory control (Dalley, Everitt, & Robbins, 2011; Ersche et al., 2012), and these findings extend to behavioral addictions (Leeman & Potenza, 2012; Yip et al., 2018). Diminished cognitive control over craving may underlie engagement in addictive behaviors (Wang, Wu, Wang, et al., 2017; Wang, Wu, Zhou, et al., 2017). Theoretical models, such as the I-PACE (Brand et al., 2016) and others (Dong & Potenza, 2014), propose that a failure in executive control may underlie problematic gaming behaviors. Studies of IGD have found hypoactivity of the brain regions involving in executive control (Nuyens et al., 2016), including the DLPFC and dorsal ACC (Dong & Potenza, 2014). Better executive control may help in controlling cravings effectively, a goal of interventions like cognitive behavioral therapy that has been applied to addictions and Internet-use behaviors like gaming (Young & Brand, 2017). We hypothesized that activation of regions implicated in executive control (DLPFC and ACC) would show greater activation following recovery as compared to during active IGD.

Given that prior studies have demonstrated DLPFC control over striatal activation in cue-elicited craving (Kober et al., 2010), we further hypothesized that changes in cortical activation would relate to control over brain activities in reward-related brain regions like the striatum. Dynamic causal modeling, an analytic approach that can be used to investigate and quantify directed influences of neuronal populations (He et al., 2019), is well suited to examine how executive regions may exert control over subcortical processes. With respect to subjective responses, we hypothesized that neural activations would relate to subjective reports of craving that we anticipated would be less strong following recovery than during active IGD.


Overview of the procedure

From 2016 to 2017, we recruited 154 IGD subjects for fMRI during a cue-craving task (described below). We contacted participants after approximately 1 year and reevaluated them for IGD. Twenty-nine IGD subjects (five females) who did not satisfy the criteria of IGD anymore agreed to participate during scanning when performing the cue-craving task. We then compare their more recent data (recovered IGD) to the baseline data (active IGD) to identify differences over time (Figure 1A).

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Figure 1. Study design and the task used in this study. (A) The design of the 1-year tracking study. (B) The timeline of one trial in this study

Subject selection

At study onset, participants were classified as having IGD if they scored 50 or higher on Young’s Internet Addiction Test (a self-report questionnaire) and met at least five DSM-5 criteria for IGD (clinical interview; see “Supplemental Material” for additional details; Petry et al., 2014; Young, 2009). All participants underwent structured psychiatric interviews (MINI) conducted by an experienced psychiatrist (Lecrubier et al., 1997), and individuals with psychiatric disorders or behaviors were excluded (see “Supplemental Material”). In addition, no subjects reported previous experience with gambling or illicit drugs (e.g., cannabis and heroin). All subjects played League of Legends (LOL and Riot Games) for more than 1 year. This criterion was based on our use of gaming cues as stimuli in this study and LOL being the most popular online game during study onset. Individuals who recovered from IGD were needed to score less than 50 on Young’s Internet Addiction Test and meet less than five DSM-5 criteria for IGD at the 1-year time (Petry et al., 2014; Young, 2009; see Table 1 for details).



Table 1. Demographic features of IGD participants when IGD was active and recovered


Table 1. Demographic features of IGD participants when IGD was active and recovered

Age (years; mean ± SD)21.46 ± 1.8321.73 ± 1.910.823>.050
IAT score (mean ± SD)65.21 ± 11.5634.45 ± 4.1018.86<.001
DSM-5 IGD score (mean ± SD)5.76 ± 0.912.83 ± 0.6615.82<.001
Self-reported craving (mean ± SD)53.07 ± 15.4730.34 ± 6.449.19<.001

Note. IAT: Internet Addiction Test; DSM: Diagnostic and Statistical Manual of Mental Disorders; IGD: Internet gaming disorder; SD: standard deviation.


An event-related cue-reactivity task was used in this study, as has been described previously (Dong et al., 2017; Dong, Wang, et al., 2018). The task contains two types of cue pictures: 30 gaming-related pictures and 30 typing-related pictures (neutral baseline). Within each type, half of the 30 pictures contained a face and hands and half contained only hands. Gaming-related pictures show a person who is playing the online game (LOL) on a computer. In typing-related pictures, the same person is typing an article on a keyboard in front of a computer. Participants were instructed to indicate whether or not there was a face in the picture by pressing the button “1” on the keyboard when a face was present and pressing “2” when there was no face present.

Figure 1B shows the timeline of a sample trial in the task. First, a fixed 500 ms of cross was presented, followed by a cue picture as described above. Pictures were presented in a randomized order to avoid order effects. Each picture was presented for up to 3,000 ms, during which time participants needed to respond. The screen turned to black after button-pressing and lasted for 3,000 (response time) ms. Then, in the craving evaluation stage, participants were asked to evaluate the level of their craving for the corresponding stimuli on a 5-point scale, ranging 1 (no craving) to 5 (extremely high craving). This stage lasted for up to 3,000 ms and was terminated by a button press. Finally, a 1,500–3,500 ms blank screen was presented between each trial. The whole task contained 60 trials and lasted approximately 9 min. The task was presented and behavioral data were collected using E-prime software (Psychology Software Tools, Inc., Sharpsburg, PA, USA). All participants were asked to complete a 10-item gaming urge questionnaire, with scores ranging from 1 to 10, to assess gaming-related craving prior to fMRI (Cox, Tiffany, & Christen, 2001).

Data analysis

Preprocessing of the fMRI data was conducted using SPM12 (http://www.fil.ion.ucl.ac.uk/spm) and Neuroelf (http://neuroelf.net), as described previously (Dong et al., 2017; Dong, Wang, et al., 2018). Images were slice-timed, reoriented, and realigned to the first volume, with T1-coregistered volumes used to correct for head movements. Images were then normalized to MNI space and spatially smoothed using a 6-mm full width at half maximum Gaussian kernel. No subjects were removed from analysis because of head motion (the exclusion criteria were 2 mm in directional movement or 2° in rotational movement). A general linear model (GLM) was applied to identify BOLD activation in relation to brain activities. Different types of trials (gaming-related, typing-related, incorrect, or missed) were separately convolved with a canonical hemodynamic response function to form task regressors. The duration of each trial was 4,000 ms. The GLMs included a constant term per run. Six head-movement parameters derived from the realignment stage and gaming history (self-reported years of gaming) were included to address these potential confounds. A GLM approach was used to identify voxels that were significantly activated for each event during the “response” stage.

The second-level analyses were conducted as follows. First, a voxel-wise repeated-measures analysis throughout the whole brain was conducted to investigate activity related to [(recoveredGaming-related stimuli − recoveredTyping-related stimuli) −  (activegaming-related stimuli − activeTyping-related stimuli)]. Family-wise error thresholds (p < .001) were determined using 3dClustSim (an updated version of Alphasim), and all comparisons were corrected using 3dClustSim (https://afni.nimh.nih.gov/pub/dist/doc/program_help/3dClustSim.html), p < .001, two-tailed, with an extent of at least 40 voxels.


This experiment was approved by the Human Investigations Committee of Zhejiang Normal University and conformed to The Code of Ethics of the World Medical Association (Declaration of Helsinki). All participants provided written informed consent before scanning.

Recovered versus active IGD subjects showed decreased brain activations in bilateral ACC, bilateral medial frontal gyrus (MFG), left lentiform, right insula, left superior temporal gyrus, and left cuneus (Figure 2A; Table 2). Beta-weight measures showed that these differences were related to decreased brain responses following recovery (Figure 2B, C).



Table 2. Comparison of brain responses of subjects with active IGD and recovered IGD


Table 2. Comparison of brain responses of subjects with active IGD and recovered IGD

Cluster numberx, y, zaPeak intensityCluster sizebRegioncBrodmann’s area
1−6, 36, −3−5.24085Left anterior cingulate12
20, 39, 6−4.57754Right anterior cingulate32
3−18, −21, −18−5.18363Left medial frontal gyrus46
427, 36, 24−5.16441Right middle frontal gyrus46
5−21, 3, 21−5.821107Left lentiform
630, −12, 27−4.74044Right insula
7−18, 36, 24−6.075436Left cuneus18
8−60, 3, 3−6.10683Left superior temporal gyrus22

Note. IGD: Internet gaming disorder.

aPeak MNI coordinates. bNumber of voxels. p < .001, cluster size > 40 contiguous voxels. Voxel size = 3 × 3 × 3. cThe brain regions were referenced to the software Xjview (http://www.alivelearn.net/xjview8) and verified through comparisons with a brain atlas.

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Figure 2. Imaging results when comparing IGD subjects in recovery and when gaming problematically. (A) Brain regions surviving after comparison between when subjects are in recovery versus actively gaming problematically. (B, C) Beta weights extracted from the ACC and lentiform regions of interest when subjects were actively gaming problematically and in recovery


We analyzed the correlations between the brain responses in the left ACC and lentiform and self-reported craving to cues. Significant correlations between self-reported cravings and lentiform activations were found, regardless of IGD status (Figure 3). No significant correlations were observed between ACC activations and cravings.

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Figure 3. (A, B) Correlations between brain ACC and lentiform activity and subjective craving when gaming in the first scan. (C, D) Correlations between brain ACC and lentiform activity and subjective craving when gaming in the second scan. (E, F) Correlations between brain ACC and lentiform activity and subjective craving when gaming in the second–first scan

Effective ACC–lentiform connectivity in IGD subjects

We further analyzed the effective connectivity between the left ACC and left lentiform using dynamic causal modeling (DCM) at the two timepoints. The nodes used were defined through the interaction results presented above. Of the several brain regions identified in the whole-brain analyses, the ACC is located in the executive-control network and the lentiform nucleus in the reward network. Given our hypothesis that executive control over craving should be changed in recovery from IGD, we selected these two brain regions as regions of interests in this study for connectivity analyses. In other words, we selected these two regions as components of executive-control and reward networks to investigate interactions between these two systems in recovery from IGD.

We took the coordinate of the peak of the clusters (local maxima in the statistical map) as the central point to create spheres with 6-mm radii [left lentiform (−21, 3, 21); ACC (−3, 39, 6)]. About 33 voxels were included in each sphere. These regions identified for each group were included in a dynamic network, and DCM was used to determine the network’s most likely structure, given the data.

In fixed connectivity, DCM estimates demonstrated significantly increased ACC–lentiform connectivity when IGD subjects recovered (t = 3.167, p = .003). Similarly, lentiform–ACC connectivity was also significantly increased when IGD subjects recovered (t = 4.399, p < .001).

Similar features were also observed when subjects were exposed to gaming cues. In modulating effects, DCM estimates demonstrated significantly increased ACC–lentiform connectivity when IGD subjects recovered (t = 2.769, p = .009). However, lentiform–ACC connectivity was only marginally increased when IGD subjects recovered (t = 1.798, p = .09; Figure 4).

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Figure 4. DCM results in IGD subjects when actively gaming problematically and during recovery. (A) The nodes that were selected for further analysis. (B) Changes in the fixed effects between the ACC and lentiform regions of interest at different time points. (C) Changes in the modulatory effects between the ACC and lentiform regions of interest at different time points


This study investigated neural features of cue reactivity in IGD subjects longitudinally to identify neural factors associated with recovery. Decreased brain responses to gaming cues in the lentiform nucleus and ACC were associated with recovery. Better effective ACC–lentiform connectivities were also observed in IGD subjects following recovery. The findings suggest that interactions between reward and executive control systems may be important in IGD.

Decreased sensitivity to gaming cues

Consistent with our hypothesis, decreased gaming cue-related activations in reward circuit-related brain regions [lentiform, ventromedial prefrontal cortex (vmPFC, including orbitofrontal cortex (OFC)] were found when IGD subjects recovered from gaming. Reward circuitry may influence motivated or goal-directed behaviors and reward processing (Ikemoto, Yang, & Tan, 2015; Sayette, 2016), including in addictions (Balodis & Potenza, 2015; Cheng et al., 2016; Tobler et al., 2016; Yang et al., 2017). The reward system could be activated when individuals are exposed to relevant stimuli in substance use or gambling disorders (Balodis et al., 2012; Worhunsky, Malison, Rogers, & Potenza, 2014) as well as in IGD (Ko et al., 2009; Liu et al., 2017; Sun et al., 2012). Individuals with IGD as compared to those with regular game use have shown higher lentiform activation to gaming cues, consistent with cue reactivity and craving findings in substance use disorders (Dong et al., 2017; Dong, Wang, et al., 2018).

In this study, decreased activations were found in the lentiform nucleus and other reward-related brain regions after recovery. The findings suggest that neural response to gaming cues decreases following recovery, which is consistent with previous studies comparing IGD with controls (Kim et al., 2018; Ko et al., 2013; Ma et al., 2019). The correlations between decreases in lentiform activation and self-reported cue-elicited craving provide support to the notion that decreased neural reactivity in the lentiform may underlie decreased cue-elicited craving responses in recovery in IGD and may relate importantly to diminished motivations to engage excessively in gaming behaviors. Our previous study showed that gaming behaviors could increase IGD subjects’ craving (Dong, Wang, et al., 2018). Furthermore, we previously reported that greater lentiform activation to gaming cues was linked to emergence of IGD in individuals with regular game use (Dong, Wang, Liu, et al., 2019). This study suggests that during recovery a decrease in problematic gaming is linked to decreased cravings in IGD, with the lentiform nucleus implicated in this relationship. Taken together, the findings suggest an important role for the lentiform nucleus and cue-elicited craving in transitions between IGD and regular game use and vice versa. The precise relationships (e.g., whether decreased gaming leads to decreased lentiform responsivity and decreased craving or whether decreased lentiform responsivity leads to decreased craving and decreased gaming) require further investigation.

Control of craving after recovery

Another brain region showing group differences was the ACC, which has been implicated in executive control and other processes. In contrast to our hypothesis, activation was decreased in the ACC (as well as in the MFG) after recovery. The cluster identified included the ACC and MFG and extended ventrally to include the vmPFC and OFC. Notably, the medial prefrontal cortex has been implicated in cue-elicited craving in substance addictions like cocaine-use disorder (Kober et al., 2016; Wexler et al., 2001), processing of rewards, especially during notification or outcome phases (Knutson, Fong, Adams, Varner, & Hommer, 2001; Knutson & Greer, 2008), decision-making (Tanabe et al., 2007), default-mode processing (Harrison et al., 2017), and other processes (Li, Mai, & Liu, 2014). Given that the task employed in this study focused on cue-elicited craving, it is tempting to speculate that the relatively decreased activation observed in the cluster involving the OFC/vmPFC/ACC/MFG may relate to diminished cue reactivity, although this interpretation is less supported by data than the lentiform findings given the absence of a correlation with self-reported cravings.

Given that the ACC and other cortical brain regions have been implicated in executive or cognitive control (Rolls, 2000), including in people with addictive disorders (Filbey et al., 2008; Franklin et al., 2007; Kosten et al., 2005; Myrick et al., 2004; Wrase et al., 2002), it is possible that individuals with IGD who have recovered are demonstrating more efficient processing of control regions relative to when they were gaming problematically. To examine relationships between ACC and lentiform activities, we applied DCM and found that the connectivities were increased following recovery. According to psychophysiological interpretations of functional connectivities among these brain regions (Havlicek et al., 2015; Stephan et al., 2010), higher values in ACC–lentiform and lentiform–ACC connectivities during recovery relative to times when gaming problematically suggest that the interactions among these two brain regions are more efficient in subjects following recovery. As such, future research should examine the extent to which this reflects a mechanism for controlling cravings more efficiently, concurrent coupling of regions involved in reward processing, or craving-related motivations or other possibilities.

Importance and clinical implications

Theoretical models have proposed important roles for cortical and subcortical brain regions in Internet-use behaviors and disorders. A recent update of the I-PACE model (Brand et al., 2019) proposed behavioral and neural mechanisms related to transitions in Internet-use disorders like IGD. In this model, cue reactivity and changes in cortical-to-basal-ganglia circuitries were important components, consistent with the findings in this study. Of note, the updated I-PACE model also proposes a role for the insula (Brand et al., 2019), consistent with changes in cue-reactivity and craving findings and insular activation and connectivity in individuals with IGD receiving a craving-behavioral intervention (Zhang et al., 2016b). Furthermore, resting-state data from the same cohort suggested decreased connectivity (e.g., between the OFC and hippocampus and between the posterior cingulate and motor-related regions; Zhang et al., 2016a). As such, this study and other recent ones suggest potential neural targets for interventions (e.g., using brain modulation methods like rapid transcranial magnetic stimulation or transcranial direct current stimulation) to reduce cravings and promote recovery in IGD. Behavioral approaches that target craving and might operate through shared or distinct neural mechanisms (e.g., cognitive-behavioral and mindfulness-based therapies) should also be considered in light of the current findings, especially given the important role for behavioral therapies in the treatment of addictions and the value of understanding how specific therapies may operate at neurobiological levels.


Several limitations should be mentioned. First, we did not include healthy control subjects in this study. Although we have found that gaming history was not related to IGD severity (r = .088, p = .494) and also included gaming history as a factor in the GLM, a control group may have been helpful in understanding the data (e.g., with respect to possible test–retest effects). Second, most study subjects were male (only five females). As such, future studies should examine the extent to which the findings may apply to female populations, especially as gender-related differences have been observed in neural correlates in IGD populations (Dong, Wang, et al., 2018; Dong, Wang, Wang, et al., 2019; Dong, Zheng, et al., 2018). Third, although we performed a DCM analysis that suggests that executive control over lentiform activation may improve with recovery, we cannot exclude other possible explanations that should be investigated directly in future studies.


IGD subjects in recovery show decreased craving responses to gaming cues at subjective and neural levels. Future research should directly examine the extent to which the findings represent cortical control over subcortical processes in craving responses versus other possibilities, and should examine how interventions targeting cortical–subcortical interactions may be effective in the treatment of IGD.

GD designed the task and wrote the first draft of the manuscript. MW and JZ collected and analyzed the data and prepared the figures and tables. XD contributed in collecting and preparing the data. MNP contributed in editing, interpretation, and revision processes. All authors contributed to and have approved the final version of the manuscript.

Conflict of interest

The authors report no financial conflicts of interest with respect to the content of this manuscript. Dr. MNP has received financial compensation for consulting and advising to RiverMend Health, Opiant/Lightlake Therapeutics, and Jazz Pharmaceuticals; has received unrestricted research support (to Yale) from Mohegan Sun Casino and grant support (to Yale) from the National Center for Responsible Gaming; and has consulted or advised legal and gambling entities on issues related to addictions and impulse control disorders.

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