Transitions into underage and problem drinking: developmental processes and mechanisms between 10 and 15 years of age (2008)

Pediatrics. 2008 Apr;121 Suppl 4:S273-89. Windle M, Spear LP, Fuligni AJ, Angold A, Brown JD, Pine D, Smith GT, Giedd J, Dahl RE. Source Department of Behavioral Science and Health Education, Emory University, 1518 Clifton Rd NE, Room 520, Atlanta, GA 30322, USA. [email protected] Abstract Numerous developmental changes occur across levels of personal organization (eg, […]

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Motivational systems in adolescence: possible implications for age differences in substance abuse and other risk-taking behaviors (2010)

Brain Cogn. 2010 Feb;72(1):114-23. Epub 2009 Sep 16.   Doremus-Fitzwater TL, Varlinskaya EI, Spear LP. Source Center for Development and Behavioral Neuroscience, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, USA. Abstract Adolescence is an evolutionarily conserved developmental phase characterized by hormonal, physiological, neural and behavioral alterations evident widely across mammalian species. For instance, adolescent […]

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The emergence of gonadal hormone influences on dopaminergic function during puberty (2010)

Horm Behav. 2010 Jun;58(1):122-37. Epub 2009 Nov 10.   Kuhn C, Johnson M, Thomae A, Luo B, Simon SA, Zhou G, Walker QD. Source Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. [email protected] Abstract Adolescence is the developmental epoch during which children become adults-intellectually, physically, hormonally and socially. Brain […]

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A unique adolescent response to reward prediction errors (2010)

Nat Neurosci. 2010 Jun;13(6):669-71. Epub 2010 May 16.   Cohen JR, Asarnow RF, Sabb FW, Bilder RM, Bookheimer SY, Knowlton BJ, Poldrack RA. Source Department of Psychology, University of California Los Angeles, Los Angeles, California, USA. [email protected] Abstract Previous work has shown that human adolescents may be hypersensitive to rewards, but it is not known […]

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Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models (2009)

Psychopharmacology (Berl). 2009 Sep;206(1):1-21. Epub 2009 Jun 23.   Schramm-Sapyta NL, Walker QD, Caster JM, Levin ED, Kuhn CM. Source Duke University, Durham, NC, USA. [email protected] Abstract BACKGROUND AND RATIONALE: Epidemiological evidence suggests that people who begin experimenting with drugs of abuse during early adolescence are more likely to develop substance use disorders (SUDs), but […]

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Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescents (2006)

J Neurosci. 2006 Jun 21;26(25):6885-92.   Galvan A, Hare TA, Parra CE, Penn J, Voss H, Glover G, Casey BJ. Source The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA. [email protected] Abstract Adolescence has been characterized by risk-taking behaviors that can lead to fatal outcomes. This […]

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Developmental Neurocircuitry of Motivation in Adolescence: A Critical Period of Addiction Vulnerability (2003)

Am J Psychiatry. 2003 June; 160(6): 1041–1052.   PMCID: PMC2919168 R. Andrew Chambers, M.D., Jane R. Taylor, Ph.D., and Marc N. Potenza, M.D., Ph.D. Abstract Objective Epidemiological studies indicate that experimentation with addictive drugs and onset of addictive disorders is primarily concentrated in adolescence and young adulthood. The authors describe basic and clinical data supporting […]

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(L) UConn Researcher: Dopamine Not About Pleasure Anymore (2012)

November 30, 2012 By: Christine Buckley, College of Liberal Arts and Sciences To John Salamone, professor of psychology and longtime researcher of the brain chemical dopamine, scientific research can be very slow-moving. “It takes a long time for things to change in science,” he says. “It’s like pulling on the steering wheel of an ocean […]

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Reduced neuronal inhibition and coordination of adolescent prefrontal cortex during motivated behavior (2011)

J Neurosci. 2011 Jan 26;31(4):1471-8.   Sturman DA, Moghaddam B. Source Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. Abstract Adolescence is a time of both cognitive maturation and vulnerability to several major psychiatric illnesses and drug dependence. There is increasing awareness that behavioral or pharmacological intervention during this period may be critical […]

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