(L) Nature and nurture teased apart in brain’s reward centre (2012)

PET scanning study has important implications for future research into disorders such as schizophrenia, addiction and Parkinson’s disease. By Eliot Barford A study by Imperial College London scientists has provided an unprecedented insight into the roles nature and nurture play in our behaviour, with important implications for future research into disorders such as schizophrenia, addiction […]

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Nature or Nurture? Determining the Heritability of Human Striatal Dopamine Function: an [18F]-DOPA PET Study (2012)

Neuropsychopharmacology. 2012 Oct 24. doi: 10.1038/npp.2012.207.   Stokes PR, Shotbolt P, Mehta MA, Turkheimer E, Benecke A, Copeland C, Turkheimer FE, Lingford-Hughes AR, Howes OD. Source 1] Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK [2] Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, […]

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Sensitivity to ethanol and other hedonic stimuli in an animal model of adolescence: implications for prevention science? (2010)

Dev Psychobiol. 2010 Apr;52(3):236-43. Spear LP, Varlinskaya EI. Source Department of Psychology, Center for Development and Behavioral Neuroscience, Binghamton University, State University of New York, Binghamton, NY 13902-6000, USA. [email protected] Abstract Age-related patterns of sensitivity to appetitive and aversive stimuli seemingly have deep evolutionary roots, with marked developmental transformations seen during adolescence in a number […]

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The emergence of gonadal hormone influences on dopaminergic function during puberty (2010)

Horm Behav. 2010 Jun;58(1):122-37. Epub 2009 Nov 10.   Kuhn C, Johnson M, Thomae A, Luo B, Simon SA, Zhou G, Walker QD. Source Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. [email protected] Abstract Adolescence is the developmental epoch during which children become adults-intellectually, physically, hormonally and socially. Brain […]

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A unique adolescent response to reward prediction errors (2010)

Nat Neurosci. 2010 Jun;13(6):669-71. Epub 2010 May 16.   Cohen JR, Asarnow RF, Sabb FW, Bilder RM, Bookheimer SY, Knowlton BJ, Poldrack RA. Source Department of Psychology, University of California Los Angeles, Los Angeles, California, USA. [email protected] Abstract Previous work has shown that human adolescents may be hypersensitive to rewards, but it is not known […]

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Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescents (2006)

J Neurosci. 2006 Jun 21;26(25):6885-92.   Galvan A, Hare TA, Parra CE, Penn J, Voss H, Glover G, Casey BJ. Source The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA. [email protected] Abstract Adolescence has been characterized by risk-taking behaviors that can lead to fatal outcomes. This […]

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(L) UConn Researcher: Dopamine Not About Pleasure Anymore (2012)

November 30, 2012 By: Christine Buckley, College of Liberal Arts and Sciences To John Salamone, professor of psychology and longtime researcher of the brain chemical dopamine, scientific research can be very slow-moving. “It takes a long time for things to change in science,” he says. “It’s like pulling on the steering wheel of an ocean […]

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Reduced neuronal inhibition and coordination of adolescent prefrontal cortex during motivated behavior (2011)

J Neurosci. 2011 Jan 26;31(4):1471-8.   Sturman DA, Moghaddam B. Source Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. Abstract Adolescence is a time of both cognitive maturation and vulnerability to several major psychiatric illnesses and drug dependence. There is increasing awareness that behavioral or pharmacological intervention during this period may be critical […]

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Striatum processes reward differently in adolescents versus adults (2012)

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1719-24. Epub 2012 Jan 17. Sturman DA, Moghaddam B. Source Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. Abstract Adolescents often respond differently than adults to the same salient motivating contexts, such as peer interactions and pleasurable stimuli. Delineating the neural processing differences of […]

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The adolescent brain (2008)

Dev Rev. 2008; 28(1): 62–77. doi:  10.1016/j.dr.2007.08.003 PMCID: PMC2500212 B.J. Casey,a,* Sarah Getz,a and Adriana Galvanb Abstract Adolescence is a developmental period characterized by suboptimal decisions and actions that give rise to an increased incidence of unintentional injuries and violence, alcohol and drug abuse, unintended pregnancy and sexually transmitted diseases. Traditional neurobiological and cognitive explanations […]

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