Developmental Neurocircuitry of Motivation in Adolescence: A Critical Period of Addiction Vulnerability (2003)

Am J Psychiatry. 2003 June; 160(6): 1041–1052.   PMCID: PMC2919168 R. Andrew Chambers, M.D., Jane R. Taylor, Ph.D., and Marc N. Potenza, M.D., Ph.D. Abstract Objective Epidemiological studies indicate that experimentation with addictive drugs and onset of addictive disorders is primarily concentrated in adolescence and young adulthood. The authors describe basic and clinical data supporting […]

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A time of change: Behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cues (2010)

Brain Cogn. 2010 Feb;72(1):124-33. Somerville LH, Jones RM, Casey BJ. Source Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065, USA. [email protected] Abstract Adolescence is a developmental period that entails substantial changes in affective and incentive-seeking behavior relative to both childhood and adulthood, including a heightened propensity to engage in risky […]

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Mental fatigue impairs midbrain function in cocaine-addicted individuals, researchers find

Fatigue can make relapse more likely. In this study, a task designed to induce fatigue activated the midbrain in healthy subjects but not in cocaine-addicted subjects (top row). However, when testsubjects were first given a dose of a pharmaceutical drug that boosts braindopamine function (methylphenidate, bottom row), these effects completely flipped: There was some midbrain […]

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The Relative Health Benefits of Different Sexual Activities (2010)

Brody, S. (2010), The Relative Health Benefits of Different Sexual Activities. Journal of Sexual Medicine, 7: 1336–1361. doi: 10.1111/j.1743-6109.2009.01677.x Keywords: Sexual Intercourse; Health Behaviors; Masturbation ABSTRACT Introduction.  Although many studies examine purported risks associated with sexual activities, few examine potential physical and mental health benefits, and even fewer incorporate the scientifically essential differentiation of specific sexual behaviors. […]

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Why does vivid memory ‘feel so real?’ Real perceptual experience, mental replay share similar brain activation patterns (2012)

July 23rd, 2012 in Neuroscience Neuroscientists have found strong evidence that vivid memory and directly experiencing the real moment can trigger similar brain activation patterns. The study, led by Baycrest’s Rotman Research Institute (RRI), in collaboration with the University of Texas at Dallas, is one of the most ambitious and complex yet for elucidating the […]

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(L) Study: People Who Are Constantly Online Can Develop Mental Disorders (2012)

Study: People Who Are Constantly Online Can Develop Mental Disorders LINK TO STUDY CHARLOTTE (CBS Charlotte) — Get off that computer. A new study finds that constantly being online can affect your mental health. Researchers at the University of Gothenburg recently studied more than 4,100 Swedish men and women between the ages of 20 and […]

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Prediction of detached personality in healthy subjects by low dopamine transporter binding (2000)

Am J Psychiatry. 2000 Feb;157(2):290-2. Laakso A, Vilkman H, Kajander J, Bergman J, paranta M, Solin O, Hietala J. Source Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland. [email protected] Abstract OBJECTIVE: Low striatal dopamine D(2) receptor binding in healthy human subjects has been associated with detached personality in studies using positron emission tomography […]

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Reprogram With Healthy Habits and Warm Fuzzies: Trumping Addictions and Compulsions

By Patricia L. Gerbarg, M.D. and Richard P. Brown, M.D. Humans are incredibly adaptable, brilliant learners. Advances in neuroscience show that we have a brain that is capable of changing itself [1]. While this confers enormous survival advantages, it also burdens us with unintended consequences: We can be reprogrammed to take pleasure from and crave […]

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DeltaFosB in the Nucleus Accumbens Regulates Food Reinforced Instrumental Behavior and Motivation (2006)

FULL STUDY The Journal of Neuroscience, 6 September 2006, 26(36): 9196-9204; doi: 10.1523/JNEUROSCI.1124-06.2006 Peter Olausson1, J. David Jentsch2, Natalie Tronson1, Rachel L. Neve3, Eric J. Nestler4, and Jane R. Taylor1 1.Correspondence should be addressed to Jane R. Taylor, Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Ribicoff Research Facilities, Connecticut Mental […]

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