Faʻafino Rev. 2019 Oketopa 1; 99 (4): 2115-2140. doi: 10.1152 / physrev.00014.2018.
Volkow ND1, Michaelides M1, Baler R1.
National Institute on Drug Abuse, Institutes National of Health, Bethesda, Maryland.
lē faʻatino
O le taumafaina fualaʻau o loʻo unaʻia e le vailaʻau o vailaʻau, o loʻo iai le faʻamanuiaga, ma e iai aafiaga ole kenera, tuputupu aʻe, ma le mafaufau e faʻafesoʻotaʻia le faʻaaogaina o fualaʻau, tulafono masani, ma aga fesoʻotaʻiga lautele pe leai foi. O le faʻamalosia o aʻafiaga o fualaʻau e tele lava ina faʻalagolago i le faʻailoaina o le dopamine i le vaega o loʻo i totonu, ma le faʻaaogaina o fualaʻau masani e faʻaosofia ai le glutamatergic-mediated neuroadaptations i le dopamine striato-thalamo-cortical (e tele lava i vaega muamua o le faʻataʻamilosaga e pei o le orbitofrontal cortex ma luma cingulate cortex) ma lala o le auala (amygdala ma hippocampus) lena, i tagata vaivai, e mafai ona faʻaiʻu ai i le fai ma vaisu. I se faʻatusatusaga, suiga i le faʻalauteleina amygdala iʻuga i le lelei lagona faʻalemafaufau tulaga e faʻaauauina fualaʻau avea o se taumafaiga e faʻamama le tumau latou. Counterintuitively, i le tagata ua fai ma vaisu, le moni fualaʻau taumafaina e fesoʻotaʻi ma le faʻateleina dopamine faʻateleina i faiai taui vaega, lea e ono fesoasoani i fualaʻau-aveina amioga e sui ai mo le eseesega i le va o le tele o le faʻamoemoe taui mafua mai e le faʻamautuina o vailaʻau faʻailo ma le mea moni na tupu i ai. I le tuʻufaʻatasia, o nei aʻafiaga e mafua ai le faʻaosofia o le faʻaosofia e "saili le vailaʻau" (malosi e le dopamine faʻateleina faʻaosoina e fualaʻau fomaʻi) ma le faʻaletonu muamua-lalo pito i lalo lava tulafono faʻatonutonu e fiafia i faʻamalosia fualaʻau-aveina i tua o le leaga o lagona le lelei ma se faʻaleleia atili feiloaʻiga ma le malamalama i le “fiaai i fualaʻau.” Togafitiga togafiti faʻamoemoeina e toe fesuiaʻi nei neuroadaptations faʻaali folafolaina o togafitiga togafitiga mo vaisu.
FUAFUAGA: cannabis; dopamine; faʻaumatia; nucleus accumbens; opioids; vailaʻau o faʻaaoga vailaʻau
PMID: 31507244
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