Dhibaatooyinka Dhibaatooyinka Dhamaan Dhibaatooyinka?
ScienceDaily (May 12, 2008) - Isticmaalida sawir-qaadista sawir-qaadista (SPECT), cilmi-baarayaasha Nederland waxay awoodeen in ay ogaadaan kala-duwanaansho la'aanta kiimikada ee maskaxda ee shakhsiyaadka qaba dhibaatooyinka bulsheed ee guud ee wacyiga (oo loo yaqaano phobia social), iyagoo bixinaya caddayn sababo dheer oo looga shakisan yahay bayoolojiga cillad la'aanta.
Daraasaddan ayaa la barbar dhigtay cufnaanta qaybaha serotonin iyo nidaamyada dopamine neurotransmitter ee maskaxda ee dadka 12 ee lagu sheegay cudurka cillada sokeeye, laakiin aan qaadan daawo si loogu daaweeyo, iyo kooxda xakamaynta ee 12 ee dadka caafimaadka qaba ee la isku daray galmada iyo da'da.
Labada kooxba waxaa lagu duray qalab shucaac leh oo ku xidha walxaha maskaxda ee serotonin iyo nidaamka dopamine. Markii la maamulo, radiotracer wuxuu shaaca ka qaaday isbeddelada waxqabadka ee nidaamyadan isaga oo cabbiraya shucaaca ku xiran thalamus, midbrain iyo pons (oo loo yaqaan in lagu dhaqmo serotonin) iyo qallalka (oo loo yaqaan in lagu dhaqmo dopamine). Waxqabadka la beddelay ee gobolladani waxay muujiyeen heer aad u sarreeya oo shaqo khalkhalsan.
"Daraasaddeennu waxay siisaa caddayn toos ah ku lug lahaanshaha nidaamka dopaminergic ee maskaxda ee khalkhalka walaaca bulshada ee bukaannada aan horay u soo gaadhin daawada, ”Ayuu yidhi Dr. van der Wee, MD, Ph.D., oo ka tirsan waaxda cilmu-nafsiga iyo Machadka Leiden ee Maskaxda iyo Garashada ee Xarunta Caafimaadka ee Jaamacadda Leiden, Leiden (oo horena uga dhacday Rudolf Magnus Institute of Neuroscience, University Medical) Xarunta Utrecht, Netherlands). "Waxay muujineysaa in walaaca bulshada uu leeyahay qeyb jir ahaan, maskax ahaan ku tiirsan."
Serotonin iyo dopamine (neurotransmitters, ama walxaha mas'uulka ka ah bedelida calaamadaha mid ka mid ah neuronka midka kale) waxay u dhaqmaan dadka soo dhaweeyaha maskaxda. Haddii neurotransmitters ay ka baxaan dheelitirka, farriintu si habboon uguma dhex mari karto maskaxda. Tani waxay bedeli kartaa qaabka maskaxdu ay uga jawaabto xaaladaha bulsheed ee caadiga ah, taasoo keeneysa walaac.
Daraasado kale oo neerfaha ah ayaa muujiyay cilladaha gulukooska iyo isticmaalka oksijiinta ee maskaxda, sida laga soo xigtay van der Wee, oo sidoo kale tilmaamaya sababaha oo ah arrin dheeraad ah. "Inta badan dadka ku lugta leh daraasaddan hore waxaa lagu yaqaanay inay horeyba u la xanuunsanayeen cilladda, markaa ma ogin haddii cilladaha aan caadiga ahayn ay jireen ka hor inta uusan cudurka bilaabin," ayuu yiri.
Iyadoo lagu saleynayo daraasado hore, cilmi baarayaashu waxay soo jeediyeen in cilladda bulsheed ee walwalka ay ka dhalatay isdhexgalka u dhexeeya u nuglaanta cilmiga hidde-ahaaneed ama deegaanka Daraasad dhowaan la sameeyay ayaa muujisay in cilladda bulsheed ee walwalka laga yaabo inay la xiriirto isku dheelitir la'aanta serotonin neurotransmitter. Tani waa markii ugu horreysay ee nidaamka dopaminergic-ka maskaxda si toos ah loo baaro.
"Inkasta oo aysan jirin saameyn toos ah oo daaweyn ah oo ka dhalatay daraasaddan wali, waa cadeymo kale oo muujinaya cilladaha cillad-bayoolajiga, taas oo horseedi karta habab daaweyn oo cusub iyo faham ku saabsan asalka cudurka," ayuu yiri Dr. van der Wee .
Sida laga soo xigtay Machadka Qaranka ee Caafimaadka Dhimirka, xanuunka bulshadu wuxuu saameeyaa qiyaastii 15 milyan dadka waaweyn ee Maraykanka ah waana kan saddexaad ee ugu caansan ee maskaxda Mareykanka, ka dib markaad niyadjabto iyo khamriga. Muuqaalka muhiimka ah ee khalkhalka waa cabsida ah in lagu qiimeeyo dadka kale, iyada oo rajeynaysa in qiimeyntan oo kale ay noqon doonto mid xun ama ka xishooneysa. Waxay u egtahay in ay maamusho koorso joogta ah oo sii socota waxayna badanaa keentaa horumarinta khamriga iyo niyadjabka. Dhibaatadu waxay inta badan dusha sare ku leedahay qaan-gaarnimada ama qaan-gaarnimada, laakiin waxay dhici kartaa wakhti kasta, oo ay ku jiraan carruurnimada.
Is-qorayaasha daraasaddan waxaa ka mid ah J. Frederieke van Veen, Irene M. van Vliet, Herman G. Westenberg, Waaxda Maskaxda; iyo Henk Stevens, Peter P. van Rijk, Waaxda Daawada Nukliyeerka, oo ka socota Rudolf Magnus Institute of Neuroscience, Xarunta Caafimaadka Jaamacadda Utrecht, Utrecht, Netherlands.
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Tixraaca Wargeyska
1. NJ van der Wee, JF van Veen, H. Stevens, IM van Vliet, PP van Rijk, HG Westenberg. Kordhinta Serotonin iyo Dopamine Transporter Waxqabadka daaweynta cudurrada maskaxda-Bukaanka qaba cudurada guud ee walaaca ee Dhibaatada Bulshada ee loo yaqaan 123I- - (4-Iodophenyl) -Teer SPECT. Wargeyska Daawada Nukliyeerka, 2008; 49 (5): 757 DOI: 10.2967 / jnumed.107.045518
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