Cilmi-nafsiyeedka Biol 2014 May 15; 75 (10): 817-24. doi: 10.1016 / j.biopsych.2013.08.026. Epub 2013 Oct 4.
Cocker PJ1, Le Foll B2, Rogers RD3, Winstanley CA4.
aan la taaban karin
DULSHADA:
Dhibaatooyinka fahamka ah ee ku saabsan natiijada khamaarka waxay keeneysaa u nugulaanta khamaarka noolaha. Isticmaalka mashiinka mashiinka mashiinka raajada ah (rSMT), waxaan hore u muujinnay in nacasku yahay quwad aan fiicnayn oo Don agonist ah oo wanaajinaya rajada khaldan ee abaalmarinta tijaabooyinka dhow, oo muujinaya doorka muhiimka ah ee qoysaska Dass Reseptor ee dhexdhexaadinta saameynta dhow ee maqan. Aqoonsiga noocyadda noocaas ah ee ku lug leh waxay fududeyneysaa kor-uqaadista daaweynta mashiinka qalabka tartanka.
XISBIGA:
Soddon laba malmood oo lab ah oo laga helay raajada faransiiska ah. Saddex nal oo midab leh ayaa la geyn karaa ama la saari karaa. Guul waxaa la calaamadeeyay haddii dhammaan saddexda laydh ayaa la dhigay, halka shay kasta oo iftiimiya oo kale muujiyay khasaaro. Kalluunka markaas ayaa doortay inta udhaxeysa lafir-ururinta, kaas oo keena sonkorta sonkorta 10 ee ku guulaysiga tijaabooyinka laakiin xaddiga 10-mar labaad oo ku saabsan tijaabooyinka lumay, ama in la bilaabo maxkamad cusub. Waxqabadka ayaa la qiimeeyay ka dib markii maamulka nidaamka DEP, D₃, iyo dukaamada D6-da.
Natiijooyinka:
Xulka xulashada 'D' antagonist L-741,626, D₃ antagonist SB-277011-A, iyo D₃ agonist PD128,907 wax saameyn ah kuma yeelan. Taa bedelkeeda, xulashada 'D' agonist PD168077 qayb ahaan waxay mideysay saameynta quinpirole, kordhinta jawaabaha khaldan ee aruurinta tijaabooyinka aan caadiga ahayn, halka D-antagonist L-745,870 uu hagaajiyay heerka qaladka. L-745,870 sidoo kale wuxuu ahaa kan kaliya ee kahortaga ee hoos udhigi kara saameynta xun ee quinpirole.
XUSUUS:
Dopamine Ditoter (Dopamine Ditamer) ayaa si xamaasad leh ugu lug leh muujinta rajada abaalmarinta rSMT. Awoodda L-745,870 si loo yareeyo kala-soocidda khasaarooyinka guuleysta waxay muujinaysaa in D6 antagonistku ay waxtar u yeelan karaan daaweynta mashiinka qalabka casriga ah.
© 2013 Bulshada Cilmi-nafsi ahaaneed ee Bioloji Waxaa daabacay Ururka Dhimirka Cilmi-nafsiga ee Biyolojiga Dhamaan xuquuqda.
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