Psychopharmacology (Berl). 2015 Jun 20.
Janssen LK1, Codka G, Hashemi MM, Timmer MH, Ter Huurne NP, Geurts DE, Cools R.
aan la taaban karin
KOOWAAD:
Khamaarka bani-aadamka ayaa lala xiriiriyay isugeynta dopamine ee isugeynta, gaar ahaan dopamine D2-yareyn soo-saartay, iyo dib u dhac xagga barashada. Intaa waxaa dheer, xisaabyahannada qalanjabinta ah waxay soo jeedinayaan doorka muhiimka ah ee dopamine ee barashada dib u celinta. Si kastaba ha ahaatee, ma jiraan wax caddayn ah oo la xidhiidha xidhiidh toos ah oo u dhexeeya dopamine, barashada dib u laabashada iyo khamaarka noolaha.
Ujeeddada:
Ujeedada daraasaddan xaadirka ah waa in la baro dopamine, barashada dib u noqoshada, iyo khamaarka noolaha.
XISBIGA:
Halkan, waxaan ku qiimeyneynaa fikradda ah in khamaarka noolaha uu weheliyo dhibaatooyinka la xiriira dopamine ee barashada abaalmarinta iyo ciqaabta iyadoo la baarayo saameynta dopamine D2-receptor antagonist sulpiride (400 mg) abaalmarinta- iyo barashada dib u noqoshada ku saleysan ciqaabta ee 18 khamaarayaasha cudurada iyo 22 xakameyn caafimaad leh, iyadoo la adeegsanayo xakamaynta placebo, laba-indhoole, naqshad isku dheelitiran.
Natiijooyinka:
Iyadoo la raacayo daraasadihii hore, xayiraadaha D2 soo celiyeyaal leh sulpiride abaal-marin naafo ah oo ka soo horjeeda barashada dib-u-celinta ee kontoroolka. Taas bedelkeeda, sulpiride wax saameyn ah kuma yeelan khamaarayaasha.
Gabagabo:
Xogtaasi waxay muujinaysaa in khamaarka ciyaalka ee la xidhiidha dopamine-ka la xidhiidha barashada dib u celinta abaalmarinta iyo ciqaabta.
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