Calaamad muujinaysa calaamadaha dopamine-ka ee sii korodhsan ee dopamin-ka ee sii-deynta khalkhalka cudurada: sawir-siiyeynta xasaasiyadda positron-ka oo lala barbar dhigo [(11) C] - (+) - PHNO (2014)

Maandooriyaha maandooriyaha ayaa lala xiriiriyay waxyeelo ka soo gaartay maskaxda dopamine (DA), hase yeeshee haddii gobolkani uu ku fidsan yahay macaamilka akhlaaqda sida khamaarka noolaha (PG) ma cadda. Halkan waxaan ku adeegsaneynaa sawirro xasaasiyadeed oo xasaasiyadeed iyo sawir-qaade D3-oo doorbidaya radioligand [(11) C] - (+) - PHNO inta lagu jiro nidaam laba-scan ah si loo baaro DA sii-deynta iyadoo la kaashanayo amphetamine afka ee qamaarka cudurada (n = 12) xakamaynta (n = 11). Marka la barbardhigo natiijooyinka ka soo baxa dareemayaasha jirka ee daroogada maandooriyeyaasha, waxaan soo sheegnaa caddaynta ugu horreysa ee PG ay la xiriirto DA sii-deyn dheeraad ah oo ku jirta qiyaasta cirbadeynta (54-63% ka weyn [(11) C] - (+) - barakaca PHNO. Muhiimad ahaan, jawaabta dopaminergic ee amphetamine ee khamaarayaasha ayaa si fiican u saadaaliyay heerarka qiyaasaha daaweynta D3 (oo lagu qiyaaso miisaanka nigra), iyo xiriir la leh khamaarka khamaarka, taas oo u oggolaanaysa dhismaha qaab farsamo oo caawin kara sharaxaadda lacagaha PG. ONatiijada urgu waxay la socotaa gobolka hyperdopaminergic ee PG, waxayna taageertaa sharaxaadda in dareenka dopaminergic ee ku lug leh hababka D3 la xidhiidha ay ka qayb qaadan karto ficil-maskaxeedka dabeecadaha akhlaaqda.