Cilmi-nafsiyeedka Biol 2017 Jun 16. pii: S0006-3223 (17) 31672-4. doi: 10.1016 / j.biopsych.2017.06.010.
van Holst RJ1, Codka G2, Janssen LK2, Janssen M3, Berry AS4, Jagust WJ4, Cools R5.
aan la taaban karin
DULSHADA:
Muuqaalka dheef-shiid kiimikaadka ah ee dopamine wuxuu door muhiim ah ka ciyaaraa fayaqabka ee khamaarka cudurada wadnaha. Si kastaba ha ahaatee, ma jirto wax caddayn ah oo toos ah oo loogu talagalay farqiga u dhaxeeya qamaarayaasha cudurada iyo maaraynta caafimaadka caafimaadka marka laga eego gudbinta dopamine ee gobolka daroogo la'aanta ah. Halkan waxaan ku siinaynaa caddaynta qiimeyntan iyada oo la isbarbardhigayo awoodda loo yaqaan 'dopamine synthesis' ee qeybaha hoose iyo qaybaha qaybta qallalka ee 13 khamaarayaasha pathologists iyo 15 maadooyinka ilaalinta caafimaadka leh.
XISBIGA:
Tani waxay gaartay iyada oo la isticmaalayo [18F] Fluoro-levo-dihydroxyphenylalanine dibad-baxa xasaasiga ah ee xasaasiyadda positron scan iyo gobollada mudnaanta ee xiisaha leh ee la soo qaaday iyadoo lagu salaynayo kormeer muuqaal ah ee sawirada sawir-celinta qowmiyadeedka sheybaarka.
Natiijooyinka:
Natiijooyinkayagu waxay muujinayaan in awoodda kobcinta dopamine loo kordhay ee qamaarka loo yaqaan "pathological gamblers" marka la barbar dhigo maadooyinka ilaalinta caafimaadka leh. Dopamine synthesis wuxuu ahaa 16% ka sarreeya jirka jirka, 17% ka sarreeya dheriga dharka, iyo 17% oo ka sarreeya qanjirka quwadda ee qamaarka loo yaqaan 'pathological gamblers' marka loo eego maadooyinka kontaroolka. Waxaa intaa dheer, awoodda dopamine ee awoodda loo yaqaan 'damealen' iyo madaxa caudate waxay si fiican u xidhiidhsan yihiin khalkhalka khamaarka ee qamaarka loo yaqaan 'pathological gamblers'.
XUSUUS:
Natiijada ka soo baxda, natiijooyinkani waxay keenaan caddayn balaadhan oo loogu talagalay kobcinta dopamine-ka ee kordhinta qalliinka wadnaha.
KEYWOOD: Maandooriyaha; Dopamine; Khamaarka; Nuuroimaging; Abaalmarin; [[18] F] DOPA
PMID: 28728675
DOI: 10.1016 / j.biopsych.2017.06.010
;