Neuropsychopharmacology. 2019 Oct 9. doi: 10.1038 / s41386-019-0534-1.
Limbrick-Oldfield EH1,2, Mick I3,4, Gubashada RE5,3, Flechais RSA3, Turton S3, Lingford-Hughes A3, Bowden-Jones H6, Clark L7,8.
aan la taaban karin
Calaamadaha cilmu-nafsiga iyo neurobiologiska ee shakhsiyaadka qaba cudurka khamaarka (GD) waxay ka tarjumayaan u nuglaanta u nuglaanta u nuglaanta balwadda ama cawaaqibka qamaarka ee mudada dheer. Adeegsiga qaab loo isticmaalo 'endophenotypic' si loo ogaado calaamadaha nuglaanta, waxaan tijaabinay ehelka noolaha ee kiisaska qaba GD. Kaqeybgaleyaasha ragga ah ee raadinaya daaweynta GD (n = 20) ayaa la barbar dhigay koox kontaroolo oo ragga ah (n = 18). Walaalaha bayoolaji ee kiisaska leh GD (n = 17, oo aan lala xiriirinin kooxda GD ee hadda jirta) ayaa la barbar dhigay koox kontaroolo oo gooni ah (n = 19) oo qayb ahaan isku soo koobay kooxda xakamaynta GD. Kaqeybgalayaashu waxay dhammeystireen qiimeyn dhameystiran oo ku saabsan cabirka caafimaad, shaqeynta neerfaha, iyo FMRI ee abaalmarinta maaliyadeed ee aan la filayn. Kooxda "GD" waxay soo bandhigtay heerar sare oo ah is-sheegis shaqsiyeed iyo dib-u-dhigis dhicis, iyo kordhinta halista qaadista ee Kambuyuutar Gamble Gamask Task. Annagu kama aannaan arag daciifnimo xagga muruqyada ah xagga shaqada calaamadda istaagidda. Walaalaha GD waxay muujiyeen xoogaa isugeyn ah; taas oo ah, kacsanaanta kacsan (degdegga deg-degga ah) iyo kordhinta qatarta qaadashada ee Kambuyuutarka Khamaarka. Annagu maanaan arkin wax farqi ah oo ka yimaadda jawaab-celinta dareen-celinta ee natiijooyinka guuleysiga, midkoodna GD ama falanqaynta walaalaha marka la barbar dhigo kooxdooda gacanta ku haysa. Kooxda 'GD' dhexdeeda, waxqabadka thalamus iyo caudate waxay si xun ula xiriireen darnaanta khamaarka. Kordhinta dareenka iyo qaadashada halista ee GD waxay ku jirtaa qaraabada noolaha ee kiisaska GD, iyagoo soo jeedinaya astaamahaan inay matalaan u nuglaanshaha hore u jireen GD.
PMID: 31597159
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