Dhibaatooyinka maskaxda. 2015 Jun 4. py: bjp.bp.114.152223.
Verdejo-Garcia A1, Clark L1, Verdejo-Román J1, Albein-Urios N1, Martinez-Gonzalez JM1, Gutierrez B1, Soriano-Mas C1.
aan la taaban karin
Background
Shakhsiyaadka leh cocaine iyo khamaarista khamaarka waxay muujinayaan dabacsanaanta isdhaafsiga garashada oo laga yaabo in ay ku adkaato dabeecadaha halista ah.
ahdaafta
Waxaan baarnaa dareenka maskaxda ee garashada cognitivity ee dadka isticmaala kookaha v. Khamaarayaasha xannibaadda, waxay ujeedadoodu tahay inay kala soocaan farsamooyinka caamka ah ee saamaynta cocaine. Mabaadiida Cocaine-ka, Qalabka Cilmi-nafsaha ee 18 iyo kormeerka 18 waxay qabteen hawlo waxbarasho oo horey u socotay intii lagu jiray sawirka maskaxeed, Qaybaha maqaarka ee DRD2 / ANKK Taq1A polymorphism.
Natiijooyinka
Isticmaalayaasha cocaine iyo khamaarayaasha xiniinyaha ayaa soo bandhigay calaamado horay loo yiraahdo Vantolateral prefrontal (PFC) inta lagu guda jiro wareega wareegga. Isticmaalayaasha cocaine-da waxay muujiyeen inay kor u kiciyaan dhaqdhaqaaqa PFC (dmPFC) ee ku xiran qamaarka loo yaqaan "pathologists" inta lagu guda jiro duruufaha, iyo hoos u dhaca dhaqdhaqaaqa PFC oo hoos udhacay qamaarayaasha iyo xakamaynta inta lagu jiro isbeddelka. Natiijooyinka hiddaha hordhaca ah ayaa tilmaamaya in dadka isticmaala cocaine ee ku socda DRD2 / ANKK Taq1A1 + genotype ay keeni karaan saameyno kiciya oo keli ah oo loogu talagalay signal-ku-beddelka is-gaarsiinta PFC.
Gabagabada
Hoos-u-dhaca firfircoon ee PFC ee hoos u dhaca inta lagu guda jiro isbeddelku wuxuu noqon karaa calaamad caadi ah oo ku saabsan khamaarka iyo kookeynta cocaine. Saameyno dheeraad ah oo la xiriira cocaine-ku waxay la xiriiraan qaabab ballaaran oo la xidhiidha dysregulation-ka, taas oo ka muuqda isbeddellada calaamadaha ee dorsolateral iyo dmPFC.
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