Eur Neuropsychopharmacol. 2010 Noof; 20 (11): 766-75. doi: 10.1016 / j.euroneuro.2010.07.010. Epub 2010 Sep 1.
Peterson E1, Møller A, Doudet DJ, Bayley CJ, Hansen KV, Rodell A., Linnet J, Gjedde A.
aan la taaban karin
Jawaab-celinta Ku-Dhaqanka Maqaarka Maqnaanshaha (SCR) ee khamaarka noolaha (PG) waxay la xiriiri kartaa farsamooyinka dopaminergic. Waxaan qoreynay tiro lamid ah maaddooyinka PG iyo maaddooyinka xakamaynta caafimaadka (HC), ka dibna tijaabinay sheegashada ah in SCR ay ku yartahay waxqabadka dopaminergic ee maadooyinka PG. Intii lagu guda jiray khamaarka firfircoon, SCR waxay ku kala duwanaayeen maadooyinka PG iyo HC (P <0.05), laakiin tomography qiiqa positron waxay muujisay isla helitaanka daawada dawada ee 'dopamine receptor'. Si kastaba ha noqotee, maadooyinka aadka u-raadinta (HS) ee maadooyinka 'PG' waxay leeyihiin helitaanka aqbalaadda dawada ee loo yaqaan 'dopamine reseptor' (P <0.0001) ee aasaasiga ah, marka la barbar dhigo maadooyinka dareenka-raadinta caadiga ah (NS) PG. Waxaan ogaanay in HS iyo kahortaga NS ay isla indho indheyn isku mid ah u sameeyeen koror xoog leh oo awood qabasho ah (BP (ND)) oo aad u sarreysa marka loo eego kuwa doonaya dareenka caadiga ah. Labada kooxba, PG iyo HC, maaddooyinka aadka u xiisaha-raadinta leh waxay si weyn kor ugu qaadeen helitaanka soo-dhoweynta ee striatum, marka la barbar dhigo maadooyinka sida caadiga ah u raadinaya dareenka, gaar ahaan (P <0.05 iyo P = 0.02, siday u kala horreeyaan) iyo wadajir (P <0.0005). Waxaan ku soo gabagabeyneynaa in SCR ay ku yartahay xaaladdiisa waxqabadka dopaminergic ee maadooyinka aadka u raadinaya dareenka, iyadoon loo eegin xaaladda PG.
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