Many opiopio nā kāne me ka erectile dysfunction hewa ʻole e manaʻo e hōʻemi ʻia ka testosterone haʻahaʻa. ʻAʻole maopopo kēia testosterone liʻiliʻi liʻiliʻi pono ke hoʻokō i kahi neʻi, ʻike nui nā haʻawina ED ʻaʻohe correlation me ka testosterone, a me ka T supplementation wale nō ke hana maikaʻi loa i nā maʻi maʻi hypogonadal.
Pōʻokoʻa testosterone pāʻani o ka poʻe hana moe kolohe a me nā kānaka kīnāʻole.
Hoʻopili i ka wahine Behav. 1980 Oct;9(5):355-66.
Schwartz MF, RC Kolodny, Masters WH.
Hōʻuluʻulu Manaʻo
Hoʻohālikelike ʻia nā pae testosterone Plasma i kahi hui o 341 mau kāne me ka pono o ka moekolohe me nā kāne ma 199 kāne me ka hana maʻamau maʻamau. Ua komo nā kumuhana āpau i kahi papahana ʻoi loa o 2 mau wiki ma ka Masters & Johnson Institute. Ua hana ʻia nā hoʻoholo testosterone e hoʻohana ana i nā hana radioimmunoassay ma hope o ka chromatography kolamu; ua loaʻa nā laʻana koko āpau i ka lā lua o ka hoʻomaʻamaʻa ma waena o 8:00 a me 9:00 o ke kakahiaka ma hope o ka wikiwiki o ka pō. Nā pae neʻe o ka testosterone i nā kāne me ka hana ʻano maʻamau ('ōleloʻo 635 ng / dl), ʻaʻole i like ʻole me nā mana testosterone ma ke ʻano he kāne male (male mean 629 ng / dl). Eia nō naʻe, ʻo nā kāne me ka impotence mua (N = 13) ʻoi aku ka nui o ke kiʻekiʻe o ka testosterone ma mua o nā kāne me ka maʻi lua (N = 180), me nā pae kiʻekiʻe o 710 a me 574 ng / dl, p (0.001). ʻO ka pae testosterone maʻamau no nā kāne me ka hemahema ejaculatory ʻo 660 ng / dl (N = 15), ʻoiai no nā kāne me ka ejaculation premature ka mean ʻo 622 ng / dl (N = 91). ʻAʻole pili nā pilina testosterone Plasma i ka hopena o ka therapy akā ua hoʻopili maikaʻi ʻole ʻia me nā makahiki o nā maʻi.
ʻO kaʻoihana'ōnaehana pituitary i loko o nā maʻi me kaʻeke erectile a me ka hoʻolālāʻana o ka wā kahiko.
Hoʻopili i ka wahine Behav. 1979 Jan;8(1):41-8.
Pirke KM, Kockott G, Aldenhoff J, Besinger U, Feil W.
Hōʻuluʻulu Manaʻo
Ua aʻo ʻia ka ʻōnaehana test pituitary i loko o nā kāne me ka maʻi psychogen. ʻEwalu mau mea maʻi me ka hiki ʻole o ka erectile pelekikena makahiki 22-36 mau makahiki, ʻewalu mau kāne me ka hānau ʻole erectile kiʻekiʻe 29-55 mau makahiki, a 16 mau kāne me ka ejaculation makahiki 23-43 mau makahiki i hoʻopaʻa ʻia Ua hoʻokaʻawale hou ʻia ka pūʻulu hope loa i ʻelua mau pūʻulu: E1 (n = 7) nā mea maʻi me ka ʻole o E2 (n = 9) nā mea maʻi me ka hopohopo a me ka pale ʻana i ka hana coital. He ʻumikūmāono kāne makua makua makahiki 21-44 i lawelawe ma ke ʻano he hui hoʻokele. Ua hana ʻia ka diagnostic ma hope o ka hoʻokolohua psychiatric a me ke kino. ʻO ka poʻe maʻi e hoʻopiʻi nui ana i ka nalowale o ka libido ʻaʻole i noʻonoʻo ʻia i ka hoʻopaʻa ʻana. He ʻumi mau koko koko i loaʻa mai i ka manawa o 3 hr mai kēlā me kēia maʻi. ʻO ka Luteinizing hormone (LH), ka nui o ka testosterone, a me ka manuahi (ʻaʻole i hoʻopaʻa ʻia ka testosterone) i hoʻopaʻa ʻia. Ua hōʻike ʻia ka helu helu helu ʻana i nāʻokoʻa nui ma waena o nā mea maʻi a me nā kaohi maʻamau.
ʻO ka testosterone a me ka testosterone e paʻa ana i nā loli i loko o nā kāne me nā maʻiʻole, oligospermia, azoospermia, a me hypogonadism.
Br Med J. 1974 Mar 2;1(5904):349-51.
Hōʻuluʻulu Manaʻo
ʻO nā pae testosterone testosterone maʻamau (+/- SD), e hoʻohana ana iā Sephadex LH-20 a me ka hoʻopaʻa ʻana i ka protein protein, he 629 +/- 160 ng / 100 ml no kahi hui o 27 mau kāne makua maʻamau, 650 +/- 205 ng / 100 ml no 27 mau kāne impotent me nā ʻano moekolohe lua maʻamau, 644 +/- 178 ng / 100 ml no 20 mau kāne me ka oligospermia, a me 563 +/- 125 ng / 100 ml no 16 mau kāne azoospermic. ʻAʻohe o kēia mau waiwai i ʻokoʻa ʻokoʻa. No nā kāne 21 me nā hōʻike maʻi o ka hypogonadism ka manaʻo o ka testosterone testosterone (+/- SD), ma 177 +/- 122 ng / 100 ml, ʻokoʻa loa (P <0.001) mai nā kāne maʻamau.ʻO ke kumu testosterone nā kaukaʻi like (e like me ke kaohi ʻana o ka nui o ka plasma e pono ai e hoʻopaʻa i ka 50% o (3) H-testosterone tracer) i like me nā kāne maʻamau, maʻi ʻole, a me ka oligospermic kāne. ʻOiai haʻahaʻa no nā kāne azoospermic ʻaʻole ʻokoʻa ka ʻokoʻa (P> 0.1). No 12 o nā kāne 16 hypogonadal he pilina maʻamau ka pilina paʻa testosterone, akā hāpai i nā pilina paʻa, like me nā mea i loaʻa i nā wahine makua kāne a i ʻole nā keikikāne prepubertal (ma kahi o ʻelua mau manawa o nā kāne kāne maʻamau), i loaʻa i nā hanana ʻehā o ka lohi o ka ʻōpio. Ke kōkua nei kēia mau hopena e wehewehe i ke kumu o ka hoʻohanaʻoleʻana o ka therapy atrapy no ka hoʻomaʻamaʻaʻana i ka maʻiʻole.
Loaʻa iā testosterone ka hana i ka hana erectile?
Am J Med. 2006 May;119(5):373-82.
PUROSE:
ʻOiai ka hana kūpono o testosterone i ka hoʻomaikaʻi ʻana i ka libido, ʻoiai ke hāʻawi maoli ʻia i ka hāʻawi ʻana i nā kūkulu ʻana i nā kāne. ^ E Ha yM. ʻO ka pahuhopu nui o kēia loiloi nei e hoʻomālamalama i ka hana o testosterone i ka hana erectile a loiloi i kāna waiwai therapeutic i nā kāne me ka erectile dysfunction (ED).
KANAKA:
ʻO ka loiloi o nā puke pono (English, French, and Spanish) mai 1939 a i Iune 2005 ua lawe ʻia me ka hoʻohana ʻana i nā kumuwaiwai. mai MEDLINE, nā puke huaʻōlelo endocrinology, a me ka huli ʻana i ka ʻōlelo pili ʻana i nā paʻi e pili ana i nā ʻatikala a me nā loiloi. Ua hoʻokomo ʻia nā hoʻokolaha lāʻau, nā noiʻi holoholona, nā hōʻike hihia, nā loiloi, a me nā alakaʻi o nā hui nui.
Nā hopena:
Wahi a nā holoholona a me nā kānaka noiʻi mua e hoʻomaʻamaʻa ka testosterone ma o ka hana ʻana he vasodilator o ka penile arterioles a me nā sinusoids cavernous. Ma hope o ka hoʻolilo ʻana, ka hapanui, akā ʻaʻole naʻe nā mea āpau, he ʻāpana a hoʻopau paha nā kāne. ʻAʻole ʻike ka Hypogonadism i ka ʻike maʻamau ma ED, e kū ana ma kahi o 5% o nā hihia, a ma ka laulā, aia ka hapa o ka pilina ma waena o nā pae serum testosterone, i ka wā i kū ai i ka pae maʻamau a i ʻole ka haʻahaʻa, a me ka hana erectile.
ʻO ka hapa nui o nā hoʻokolohua e hoʻohana ana i ka testosterone no ka mālama ʻana iā ED i nā kāne hypogonadal e hōʻeha i nā pilikia metala a hōʻike i nā hopena inconsistent, akā ma ka hapanui, ke manaʻo nei paha ka testosterone e ʻoi aku ka maikaʻi ma ka pletebo. ʻOi aku ka maikaʻi o ka hana Erectile i ka hoʻomaikaʻi ʻana me ka testosterone testosterone i nā maʻi me nā maʻi koʻikoʻi o ka hypogonadism.
Hoʻomaʻamaʻa ʻia ka testosterone testosterone i ka pane ʻana i ka inhibitor phosphodiesterase 5 (PDE5) i nā kāne a me nā kāne me nā testosterone serum haʻahaʻa. Hōʻike ʻia ka ʻike ʻana o ka testosterone serum ka nui piha ma ke ʻano he kūpono kūpono no ka loiloi i ka androgenecity, akā ua ʻōlelo ʻia ka nui o ka testosterone ai ʻole bioavailable i loko o nā kūlana e hoʻololi ai i nā pae o ka sexobine sex-hormone-binding (SHBG), e like me ka mea elemakule a me nā makahiki ma nā momona.
NĀ KUMU:
Hōʻike nā data i loaʻa i ka hapa nui o nā kāne e neʻe ana i nā pae o testosterone, ma lalo o ke ʻano maʻamau, pono no ka neʻe maʻamau a me ka that kiʻekiʻe kiʻekiʻe ma muli o ka serum testosterone i loaʻa ʻole i ka hopena koʻikoʻi ma ka hana erectile. Pono ke nānā ʻana no ka hypogonadism i nā kāne a pau me ka ED i mea e ʻike pono ai i nā hihia o ka hypogonadism koʻikoʻi a me kekahi mau hihia o ka hypogonadism maʻalahi, nā mea e pōmaikaʻi ana mai ka testosterone testosterone.
ʻO ka hoʻohanohano o ka hypogonadism i ka uahi erectile.
World J Urol. 2006 Dec;24(6):657-67.
Hōʻuluʻulu Manaʻo
No ka loiloi i ka hana a me ka ʻike nui o ka hypogonadism, i hoʻākāka ʻia me kahi haʻahaʻa o testosterone (T) haʻahaʻa, ma ka erectile dysfunction (ED). Hōʻikeʻike i ka palapala.
ʻO Serum T ma lalo o 3 ng / ml i 12% o nā maʻi ED, me ka 4% ma mua a me 15% ma hope o ka makahiki o 50. Ke hōʻike nei nā haʻawina hoʻowalewale i nā kāne me ka hypogonadism koʻikoʻi e hōʻike ana i ka makemake moekolohe a me ka uluʻana, me ka pinepine o ka hana moekolohe a me nā kiʻi kūʻai. ʻO nā neʻe psychic kekahi hapa T-hilinaʻi. ʻO ka hopena o T ma luna o ka hana pilikino ka mea i hilinaʻi ʻia i ka pae paepae e kū nei i loko o kahi kanaka hoʻokahi, akā ʻano ākea ma waena o kēlā me kēia kanaka, mai 2 a 4.5 ng / ml. Pono hou nā hōʻike e hōʻoia i ka hopena nui o T ma ka intrapenile vascular mekanitions o nā erections i kāne e like me ka hihia ma nā holoholona.
ʻAʻole i ʻike ʻia ka pilina o T me ED me nā haʻawina epidemiological. E like me ka manaʻo o ka ʻike loiloi, ʻoiai he meta-kaohi ʻana o nā hoʻokolohua hoʻokolohua paʻa i hoʻokau e hoʻomau ʻia ka hoʻolaʻa T me ka hana erectile i nā maʻi hypogonadal ʻōpio me T ma lalo o 3.46 ng / ml, ʻo nā hopena o kēia ʻano mea hōʻeha i ka wā i hoʻohana wale ʻia ai i nā maʻi kahiko. kūkākūkā no ED no nā mea i hōʻike ʻia e loaʻa i ka hypogonadism ma hope o ke ana ʻana o ka laulā T. Kēia mau hopena maikaʻi paha e wehewehe ʻia e ka prevalence o ka co-morbidities kiʻekiʻe, a me ka manaʻo maoli o ED iho e hoʻonāukiuki i ka hypogonadism.
Hiki i ka hopena ʻo ka hui pū me T a me PDE5 inhibitor (PDE5I) i ka maʻi hypogonadal ED i ka wā hiki ke hoʻōla wale ʻia ʻo T terapi. Eia nō naʻe, koi ʻia nā hōʻike e hōʻoia i ka hypothesis e koi ʻia kahi pae liʻiliʻi loa o ka T no ka hopena piha o PDE5I i kekahi mau kāne, ʻoiai ua hiki i kahi PDE5I ke hoʻihoʻi i nā kikowaena piha i nā kāne hypogonadal koʻikoʻi. ʻOiai ʻaʻole haʻahaʻa loa ka pae haʻahaʻa T i nā kumu maʻamau o ED i ka maʻi o ka maʻi hypogonadal ED, aia nā mea nui i loaʻa i nā pono nui no ka nānā ʻana no ka hypogonadism ma ED. ʻO ka haʻahaʻa haʻahaʻaʻo T e hōʻoia i kahi hoʻokolokolo 3 mahina o T therapy, ma mua o ka hoʻopili ʻana i kahi PDE5I inā hiki wale nō ke mālama T T maʻi.
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