Natural and Drug Rewards Act on Common Neural Plasticity Mechanisms with ΔFosB as a Key Mediator (2013)

This study examined the effects of sexual reward on DeltaFosB and the effects of DeltaFosB on sexual behavior and reward. The standard molecular changes known to occur with drug addiction were found to be the same as occur with sex. In other words, DeltaFosB evolved for sexual stimuli, yet drugs hijack this very same mechanism. […]

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Cybersex addiction: Experienced sexual arousal when watching pornography and not real-life sexual contacts makes the difference (2013)

COMMENTS:  Study found cue-induced cravings, similar to drug addicts, predicted porn addiction. Contrary to popular belief, unsatisfying sexual life had no correlation to porn addiction. Supporting the gratification hypothesis means addiction-like behaviors in response to ones chosen addiction. Laier, C., Pawlikowski, M., Pekal, J., Schulte, F. P., & Brand, M. (2013).  Journal of Behavioral Addictions. […]

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Reward, dopamine and the control of food intake: implications for obesity (2011)

Trends Cogn Sci. 2011 Jan;15(1):37-46. doi: 10.1016/j.tics.2010.11.001. Epub 2010 Nov 24. Volkow ND, Wang GJ, Baler RD. Source National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA. [email protected] Abstract The ability to resist the urge to eat requires the proper functioning of neuronal circuits involved in top-down control to oppose the […]

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Sugar and Fat Bingeing Have Notable Differences in Addictive-like Behavior (2009)

J Nutr. 2009 March; 139(3): 623–628. doi:  10.3945/jn.108.097584 PMCID: PMC2714381 Nicole M. Avena 1 , 2 , Pedro Rada 1 , and Bartley G. Hoebel 1 , * + Author Affiliations 1Department of Psychology, Princeton University, Princeton, NJ 08540 and 2The Rockefeller University, New York, NY 10021 *To whom correspondence should be addressed. E-mail: [email protected]. […]

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Effect of ΔFosB overexpression on opioid and cannabinoid receptor-mediated signaling in the nucleus accumbens (2011)

Neuropharmacology. 2011 Dec;61(8):1470-6. doi: 10.1016/j.neuropharm.2011.08.046. Sim-Selley LJ, Cassidy MP, Sparta A, Zachariou V, Nestler EJ, Selley DE. Source Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA. Abstract The stable transcription factor ΔFosB is induced in the nucleus accumbens (NAc) by chronic […]

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