Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake (2006)

J Neurosci. 2006 Jul 5;26(27):7163-71. Le Merrer J1, Stephens DN. PMID: 16822973 DOI: 10.1523/JNEUROSCI.5345-05.2006 Abstract Repeated administration of abused drugs sensitizes their stimulant effects and results in a drug-paired environment eliciting conditioned activity. We tested whether food induces similar effects. Food-deprived male mice were given novel food during 30 min tests in a runway (FR […]

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When Chocolate Seeking Becomes Compulsion: Gene-Environment Interplay (2015)

Enrico Patrono , Matteo Di Segni , Loris Patella, Diego Andolina, Alessandro Valzania, Emanuele Claudio Latagliata, Armando Felsani, Assunta Pompili, Antonella Gasbarri, Stefano Puglisi-Allegra, Rossella Ventur Published: March 17, 2015 http://dx.doi.org/10.1371/journal.pone.0120191 Abstract Background Eating disorders appear to be caused by a complex interaction between environmental and genetic factors, and compulsive eating in response to adverse […]

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Transitionality in addiction: A “temporal continuum” hypotheses involving the aberrant motivation, the hedonic dysregulation, and the aberrant learning (2016)

Med Hypotheses. 2016 Aug;93:62-70. doi: 10.1016/j.mehy.2016.05.015. Patrono E1, Gasbarri A2, Tomaz C3, Nishijo H4. Article Outline Introduction The “incentive-sensitization” theory The “hedonic dysregulation” theory The “habit-based learning” theory A “temporal continuum” hypotheses involving the aberrant motivation, the hedonic dysregulation, and the aberrant learning Neuro-bio-physiological background of drug addiction “temporal continuum” hypotheses The neural basis of […]

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Rebooting my marriage in general, and our sex life: Sex is becoming something she looks forward to

Well, I’ve hit a 60 day milestone in being PMO-free. The first 30 days were very much focused on figuring out an effective path to discontinuing PMO, and the last 30 days I’ve been able to focus on rebooting my marriage – in general and our sex life. Before starting NoFap, I was on a […]

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How Internet Porn Is Making Young Men Impotent. Sex therapist and associate of Impotence Australia, Alinda Small (2016)

A look at the science behind porn-induced erectile dysfunction. 03/06/2016 6:26 AM AEST | Updated June 21, 2016 12:39 Emily Blatchford Associate Lifestyle Editor, HuffPost Australia Ever come across the acronym PIED? It stands for ‘Porn Induced Erectile Dysfunction‘, and it’s a condition affecting young Australian men. In fact, according to relationship counsellor, sex therapist […]

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Excessive cocaine use results from decreased phasic dopamine signaling in the striatum (2014)

Nat Neurosci. Author manuscript; available in PMC 2016 Jan 15. Published in final edited form as: Nat Neurosci. 2014 May; 17(5): 704–709. Published online 2014 Apr 6. doi:  10.1038/nn.3694 PMCID: PMC4714770 NIHMSID: NIHMS574802 Ingo Willuhn,1,2,3,* Lauren M. Burgeno,1,2 Peter A. Groblewski,2 and Paul E. M. Phillips1,2 Author information ► Copyright and License information ► The […]

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Loss of phasic dopamine signaling: a new addiction marker (2014)

Nat Neurosci. Author manuscript; available in PMC 2016 Jun 30. Published in final edited form as: Nat Neurosci. 2014 May; 17(5): 644–646. PMCID: PMC4928687 NIHMSID: NIHMS791448 Daniele Caprioli, Donna Calu, and Yavin Shaham Author information ► Copyright and License information ► See the article “Excessive cocaine use results from decreased phasic dopamine signaling in the […]

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