Search Results for: brain change

Stress resistance may come from one protein and its many effects on the nucleus accumbens (2014)

The molecular path of best resilience Stress resistance may come from one protein and its many effects by Bethany Brookshire November 25, 2014 Most mice will spend a lot of time making friends. But some mice that have been bullied at the paws of another mouse prefer to stay away. This susceptibility to defeat is […]

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Animal models of alcohol and drug dependence (2013)

Rev Bras Psiquiatr. 2013;35 Suppl 2:S140-6. doi: 10.1590/1516-4446-2013-1149. Planeta CS. Abstract Drug addiction has serious health and social consequences. In the last 50 years, a wide range of techniques have been developed to model specific aspects of drug-taking behaviors and have greatly contributed to the understanding of the neurobiological basis of drug abuse and addiction. […]

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Dynamics of Neuronal Circuits in Addiction: Reward, Antireward, and Emotional Memory (2009)

Pharmacopsychiatry. Author manuscript; available in PMC Sep 8, 2009. Published in final edited form as: Pharmacopsychiatry. May 2009; 42(Suppl 1): S32–S41. Published online May 11, 2009. doi:  10.1055/s-0029-1216356 PMCID: PMC2739305 NIHMSID: NIHMS140629 George F. Koob, Ph.D. Author information ► Copyright and License information ► The publisher’s final edited version of this article is available at […]

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Making a bad thing worse: adverse effects of stress on drug addiction (2008)

J Clin Invest. Feb 1, 2008; 118(2): 454–461. doi:  10.1172/JCI33946 PMCID: PMC2214707 Jessica N. Cleck and Julie A. Blendy Author information ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract Sustained exposure to various psychological stressors can exacerbate neuropsychiatric disorders, including drug addiction. Addiction is […]

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Neurobiological mechanisms for opponent motivational processes in addiction (2008)

Philos Trans R Soc Lond B Biol Sci. Oct 12, 2008; 363(1507): 3113–3123. Published online Jul 24, 2008. doi:  10.1098/rstb.2008.0094 PMCID: PMC2607326 George F Koob1,* and Michel Le Moal2 Author information ► Copyright and License information ► This article has been cited by other articles in PMC. Go to: Abstract The conceptualization of drug addiction […]

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Neurobiological Substrates for the Dark Side of Compulsivity in Addiction (2009)

Neuropharmacology. Author manuscript; available in PMC Jan 1, 2010. Neuropharmacology. 2009; 56(Suppl 1): 18–31. Published online Aug 7, 2008. doi:  10.1016/j.neuropharm.2008.07.043 PMCID: PMC2637927 NIHMSID: NIHMS86836 George F. Koob, Ph.D. Author information ► Copyright and License information ► The publisher’s final edited version of this article is available at Neuropharmacology See other articles in PMC that […]

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The Role of CRF and CRF-related Peptides in the Dark Side of Addiction (2014)

Brain Res. Author manuscript; available in PMC Feb 16, 2011. Brain Res. Feb 16, 2010; 1314C: 3. Published online Nov 11, 2009. doi:  10.1016/j.brainres.2009.11.008 PMCID: PMC2819562 NIHMSID: NIHMS164224 George F. Koob, Ph.D. Abstract Drug addiction is a chronically relapsing disorder characterized by a compulsion to seek and take drugs, the development of dependence, and the […]

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