Age 31 – ED cured, less social anxiety & depression, more social, increased attraction to real women

(90 days) I started out watching soft-core porn when I was 9 (Friday/Saturday nights on Cinemax, also known as Skinimax). I started masturbating a year later however, when I was 10. For the next few years, that was my PMO experience (little did I know, I was getting some of my fetishes hardwired into my […]

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Sexual Behavior and Sex-Associated Environmental Cues Activate the Mesolimbic System in Male Rats (2004)

Neuropsychopharmacology (2004) 29, 718–730, Margaret E Balfour1, Lei Yu1 and Lique M Coolen1 1Neuroscience Graduate Program, Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH, USA Correspondence: Dr LM Coolen, Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Vontz Center for Molecular Studies, 3125 Eden Ave., Cincinnati, […]

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Age 24 – Harder & longer lasting erections, strong urge for real women, greater confidence

24 years old. Hardmode. At day 21 and day 25 I dry humped a girl and orgasmed. Watched porn maybe 7 to 8 times and edged accordingly, with regret because it does slow down progress. You can feel this afterwards when you walk down the street and look at girls. Superpowers: Confidence rises with as […]

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Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine Neurons (2012)

Cold Spring Harb Perspect Med. 2012 Jul;2(7):a012070. doi: 10.1101/cshperspect.a012070. Michelle S. Mazei-Robison and Eric J. Nestler + Author Affiliations Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029 Correspondence: [email protected] Next Section Abstract The study of neuronal adaptations induced by opiate drugs is particularly relevant today […]

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Endogenous opioid-induced neuroplasticity of dopaminergic neurons in the ventral tegmental area influences natural and opiate reward (2014)

COMMENTS: The DeltaFosB studies we often cite all focused on the nucleus accumbens (reward center), and found that sex pretty much trip the same brain mechanisms as meth & cocaine. From the landmark study by this same researcher (Natural and Drug Rewards Act on Common Neural Plasticity Mechanisms with ΔFosB as a Key Mediator (2013)): […]

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Striatal regulation of DeltaFosB, FosB, and cFos during cocaine self-administration and withdrawal (2010)

J Neurochem. Author manuscript; available in PMC Oct 1, 2011. Published in final edited form as: J Neurochem. Oct 2010; 115(1): 112–122. Published online Aug 3, 2010. doi:  10.1111/j.1471-4159.2010.06907.x Erin B. Larson,* Fatih Akkentli,* Scott Edwards, Danielle L. Graham, Diana L. Simmons, Imran N. Alibhai, Eric J. Nestler,1 and David W. Self Author information ► […]

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Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens (2006)

Proc Natl Acad Sci U S A. Feb 28, 2006; 103(9): 3399–3404. Published online Feb 21, 2006. doi:  10.1073/pnas.0511244103 PMCID: PMC1413917 Neuroscience Ko-Woon Lee,* Yong Kim,* Amie M. Kim,* Kathryn Helmin,† Angus C. Nairn,*‡ and Paul Greengard*§ Author information ► Copyright and License information ► This article has been cited by other articles in PMC. […]

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Female – Age 19 & French: I’m fully rebooted sexually, no longer chronically depressed

6 months ago, I decided I would try not to look at porn or masturbate (masturbation without porn being impossible to even be thought of) for three days. I did this spontaneously, after looking at this interview of the singer I was in love with at the time. Why did I decided this? First, because […]

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Increased Impulsivity Retards the Transition to Dorsolateral Striatal Dopamine Control of Cocaine Seeking (2014)

Biological Psychiatry Volume 76, Issue 1, Pages 15–22, July 1, 2014 Jennifer E. Murray   Ruth Dilleen   Yann Pelloux   Daina Economidou   Jeffrey W. Dalley   David Belin   Barry J. Everitt Received: May 21, 2013; Received in revised form: September 18, 2013; Accepted: September 18, 2013; Published Online: October 23, 2013 DOI: http://dx.doi.org/10.1016/j.biopsych.2013.09.011 […]

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