I-Nucleus accumbens Ukuvuselelwa kwe-NMDA yokusungula kuqondisa u-amphetamine ukuzwela ukuhamba phambili kanye ne-deltaI-expression ye-FoosB elandela isipiliyoni socansi kuma-rats angamadoda (i-2015)

2015 Septhemba 21;101:154-164. doi: 10.1016/j.neuropharm.2015.09.023.

I-Beloate LN1, Ukhula PW1, Casey GR2, I-Webb IC2, Coolen LM3.

abstract

Umuzwa wokuya ocansini kumagundane abesilisa alandelwa isikhathi sokuyeka ukubangela ukuzwela emvuzweni we-d-Amphetamine (Amph), okufakazelwa ukwanda kokuthanda indawo okukhona (i-CPP) ngemithamo ephansi ye-Amph. Ngaphezu kwalokho, okuhlangenwe nakho kwezocansi kufaka i-neural plasticity ngaphakathi kwe-nucleus accumbens (NAc), kufaka phakathi ukwenziwa kwe-deltaFosB, ebamba iqhaza elibalulekile ekuzuzeni izinzwa kwe-Amph.

I-NMDA receptor subunit i-NR1 nayo iyabhalwa ngokuhlanganiswa komzimba, kodwa ukufana kokusebenza kwama-receptors e-NMDA emiphumeleni yokufaka ocansini ayaziwa.

Lapha, sihlole umthelela wokufakwa kwe-intra-NAc MK 801 kokuhlangenwe nakho kocansi okwenziwe nge-NAc deltaFosB kanye nenkulumo ye-cFos, kanye nokuzalela- kanye ne-Amph-indved CPP emagundwini amadala abantu besilisa.

Ekuzameni i-1, abesilisa bathola i-MK 801 noma i-saline kwi-NAc ngesikhathi ngasinye sezinsuku ezilandelanayo ze-4 zokukhwelana noma zokubamba futhi bahlolwa i-Amph CPP kanye ne-deltaFosB 10 yezinsuku ngemuva.

I-Intra-NAc MK 801 ngesikhathi sokuziphatha kocansi ivimbele ukwanda okubangelwa isipiliyoni ku-Amph CPP kanye nenkulumo ye-NAc deltaFosB ngaphandle kokuthinta ukusebenza kocansi.

Ekulingweni kwe-2, imiphumela ye-intra-NAc MK 801 ku-CPP eyenziwe nge-mating ihlolwe ngokufakwa kwe-intra-NAc kwe-MK 801 noma i-saline ngaphambi kokuzalela ngezinsuku zokulungisa. I-Intra-NAc MK 801 ayikhinyabezanga i-CPP-indened

Okulandelayo, imiphumela ye-intra-NAc MK 801 ku-cFos immunoreactivity yahlolwa. I-MK 801 ivimbele ukuvela kwe-cFos ye-mating-in ikiwa kwi-NAc igobolondo kanye nomongo.

Ngokubambisana, le miphumela inikezela ngobufakazi bokuthi i-NAc NMDA receptor activation ngesikhathi sokuziphatha kobulili idlala indima enkulu ekuqhathaniseni i-cFos kanye nenkulumo ye-deltaFosB kanye nokuhlangenwe nakho okulandelayo-okuholele ekuqwashiseni i-cross-sensitization to the Amphomvu.