J Psychopharmacol. 2004 Dec;18(4):544-52.
I-Franken IH1, IHulstijn KP, Stam CJ, IHendriks VM, van den Brink W.
abstract
Ukufisa i-cocaine kungenye yezimpawu zokuncika kwe-cocaine. Enye yezinkinga ngokulangazelela ukukala kwayo. Ama-indices endabuko yengqondo yendabuko njengokuziphatha kwesikhumba kanye nenhliziyo ikhiphe imiphumela ephikisanayo. Lezi zindlela zokufisa zitholwe zihambelana kuphela ngokulinganisela nokukhanuka okuzenzakalelayo kokubikwa. Ocwaningweni lwamanje, izinto ezihambelana nobuchopho ezihlobene nomcimbi (i-ERPs) kanye nokuphendula kwe-cue module (CMSR) kuhlolwa njengezinkomba zokufisa i-cocaine. Izifundo ezingaphansi kwamashumi amabili nanye ezivinjelwe i-cocaine zahlukaniswa zaba ziinqola eziphakeme nezisezingeni eliphansi ngokususelwa ekuhlukaniseni okuphakathi kwezikolo ezizibizayo zokukhanuka. Ama-ERPs ne-CMSR alinganiswa lapho izifundo zibukela izithombe ezingathathi hlangothi, zimnandi, zingathandeki futhi zihlobene ne-cocaine. Sekukonke, kwatholakala ukuthi izihloko ezincike ku-cocaine zikhombisa amagagasi ahamba kancane (ama-SPW) we-ERP ezithombeni ze-cocaine ngokuqhathaniswa nezithombe ezingathathi hlangothi. Abafisi abaphezulu kuphela ababonise ama-SPW amakhulu emikhondweni ye-cocaine, bephakamisa ubudlelwane phakathi kwe-SPWs ekhonjwe yi-cWs nokuzibika kwesifiso se-cocaine. Ngokuphikisana nezinyathelo ze-ERP, i-CMSR ayizange ihlukanise phakathi kwezithombe ze-cocaine nezithombe ezingathathi hlangothi. Ngaphezu kwalokho, akukho mehluko phakathi kwesifiso esiphansi nesiphezulu esilinganisweni se-CMSR esitholakele. Imiphumela yamanje ikhombisa ukuthi i-paradigm evuswe-potentials inikeza imiphumela ethembisayo yokufisa kwenkomba ye-cue-elicised. Ukusetshenziswa kokushintshwa kokuqala kufanelwe ukuphenywa okwengeziwe.
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