Am J Psychiatry. 1997 Feb; 154 (2): 239-42.
UTiihonen J, Kuikka J, Bergström K, Lepola U, Koponen H, Leinonen E.
Umthombo
UMnyango Wezokwelapha I-Forensic Psychiatry, iYunivesithi yaseKuopio, eFinland.
abstract
INJONGO:
Kuye kwaphakanyiswa ukuthi i-phobia yezenhlalo ihlotshaniswa nokuhluleka kwezinhlelo ze-noradrenergic ne-dopaminergic, kodwa ayikho idatha esetshenzisiwe ye-anatomic ekungahleleki kwe-monoaminergic etholakala ebuchosini bezifo ze-phobic. Ababhali bafunda ukuxilongwa kwamasayithi e-dopamine reuptake ezigulini ezinezinhlalo zomphakathi.
INDLELA:
Ucwaningo lwaluhlanganisa neziguli ze-11 ezinezimo zenhlalo kanye nezihloko zokuqhathanisa okunempilo ze-28, i-11 yazo eyayineminyaka yobudala nobulili efanelwe neziguli zokuhlaziya. Ukulinganisa kwesisindo samasayithi wokubuyisela kabusha i-dopamine senziwa ngokusebenzisa i-analogue ye-cocaine ebizwa nge-123I, i- [123I] beta-CIT, ngokukhipha okukodwa kwe-photon kubhalwe tomography (SPECT).
IZIPHUMA:
Ukuhlaziywa kwamathambo okumbumbulu kubonisa ukuthi izifo ezincane zokuhlaselwa kwe-dopamine reuptake zangehla kakhulu ezigulini ezinezinhlalo zomphakathi kunezihloko zokuqhathanisa nobudala bobulili.
IMIBUZO:
Imiphumela ibonisa ukuthi i-phobia yezenhlalo ingase ihlotshaniswe nokuhluleka kwesistimu ye-dopaminergic yokuhlaselwa.
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