I-Mol Psychiatry. 2013 May 28. i-doi: 10.1038 / mp.2013.57.
Trifilieff P, Feng B, Urizar E, I-Winiger V, I-Ward RD, Taylor KM, Martinez D, Moore H, Ibhalsamu PD, Simpson EH, IJavitch JA.
Umthombo
I-1] UMnyango we-Neuroscience, i-Columbia University, eNew York, i-NY, e-USA [2] eNew York State Psychiatric Institute, eNew York, e-NY, e-USA.
abstract
Ukunciphisa i-dopamine D2 receptor (D2R) ebophayo ku-striatum ingenye yezinto ezivame ukutholakala ezinkingeni ezibandakanya ukuhlukunyezwa kwesisusa, okufaka ukukhuluphala, ukulimala nokukhathazeka kokungabi nakakhulu. Njengoba ukuphazanyiswa kwe-D2R ukufaka uphawu emgodini we-ventral-kuhlanganise ne-nucleus accumbens (NAc) -imigomo yokugqugquzela, sifuna ukunquma ukuthi kungenzeka yini ukubonisa ukuxhomeka kwe-D2R ekuxhasweni kwe-NAc kungathuthukisa isisusa. Kulolu cwaningo, sasebenzise isu lokuvotela i-viral ukuze sisebenzise ama-D2R ama-postsynaptic ku-NAc noma i-dorsal striatum. Siphenya imiphumela ye-D2R ngokweqile ekufundeni kwezinsimbi, ukuzimisela ukusebenza, ukusebenzisa izethulo zokubaluleka komvuzo nokuguqulwa kwesisusa ngemiphumela ehambisanayo nomvuzo.
Ukucindezeleka okukhulu kwe-postsynaptic i-D2R ku-NAc ikhetha ukugqugquzela okwedlulele ngaphandle kokushintsha ukuziphatha okudliwayo, ukumelelwa kokubaluleka kwe-reinforcer, noma amandla okusebenzisa imivuzo ehambisanayo ngezindlela eziguquguqukayo. Ngokuphambene nalokho, ukucindezeleka okukhulu kwe-D2R ku-dorsal striatum akuzange kushintshe ukusebenza kunoma yimiphi imisebenzi.
Ngakho-ke, ngokuhambisana nezifundo eziningi ezibonisa ukuthi kunciphise ukusayinda kwe-D2R kukhubaza isimilo, idatha yethu ikhombisa ukuthi i-postynaptic D2R overexpression ku-NAc ikhulisa kakhulu ukuzimisela kwesilwane ukusebenzisa umzamo wokuthola umgomo. Ukuhlanganiswa, le miphumela ihlinzeka ngokuqondisisa ngomthelela ongase ube nawo wezinqubo zokwelapha ezizayo ezithuthukisa ukusayina kwe-D2R ku-NAc.Izincwadi ze-Psychiatry ezithuthukisiwe kusengaphambili, i-28 May 2013; i-doi: 10.1038 / mp.2013.57.
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