I-Neuropsychopharmacology. 2015 Aug 20. doi: 10.1038 / npp.2015.253.
I-Kerstetter KA1, I-Wunsch AM1,2, Nakata KG1,2, Kunika i-E1, Neumaier JF2,3,4, I-Ferguson SM1,2,3.
abstract
I-medial prefrontal cortex (mPFC) ne-nucleus accumbens (NAc) zombili ziyizici ezibalulekile zokujikeleza kwe-cortico-basal ganglia-thalamic elawula indlela yokuziphatha ehlobene nokulutha. Kodwa-ke, izindima zokufakwa kokuhambisana kusuka ku-mPFC kuya kwi-NAc kulezi zindlela zokuziphatha akucaci.
Ukubhekana nalokhu, sisebenzise indlela ye-ve-veombinase encike ku-G ukuze iveze uGi / oAma-DREADDs ahlanganisiwe (Ama-Receptors WeMklami Akhiqizwa Ngokungafani NeZidakamizwa Zokuqamba) ngokukhetha ku ama-mPFC neurons aqala ukusebenza ku-NAc futhi ahlole imiphumela yokuthola umsebenzi walezi zinzwa ekuqhelisweni kokuzwela i-amphetamine nasekuthatheni izidakamizwa nasekufuneni izidakamizwa ngesikhathi sokuzilawula kwe-cocaine.
Ngokumangazayo, ukuncipha kokusebenzisana kwe-mPFC kwi-NAc kuncishiswa okwesikhashana ukuzwela kwendawo futhi akubanga nomthelela ekudleni izidakamizwa ngesikhathi sokuzilawula kwe-cocaine.
Kodwa-ke, kuvimbela umsebenzi wokuhlangana we-corticostriatal ngesikhathi sokuzwela kokuphendula okubuye kube ngcono okuphenduliwe.
Ngaphezu kwalokho, lokhu kusebenzisa amandla ngesikhathi sokulawulwa kwezidakamizwa kuholele ekuqothulweni okuhamba kancane futhi kukhuphuke ukuphendula ngesikhathi sokubuyiselwa kwezidakamizwa-umphumela obujwayelekile ngokuvimbela lezi zibambiso ze-corticostriatal ngokushesha ngaphambi kwephambili lezidakamizwa.
Le miphumela iphakamisa ukuthi ukunciphisa ukulawulwa kwe-NAc ngesikhathi sokuchayeka kwezidakamizwa kungaholela kwizinguquko zesikhathi eside emandleni wezidakamizwa kanye nesisusa esihambisana nokushayela
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