Izindima ezihlukene zezindawo eziphambene nezindawo zokulawula izidakamizwa ekulawulweni kwezidakamizwa (2014)

I-cortex yangaphambili idlala indima ebalulekile ekubumbeni ukuqonda nokuziphatha. Ucwaningo oluningi selukhombisile ukuthi i-medial prefrontal cortex (mPFC) idlala indima ebalulekile ekufuneni, ekuqothulweni nasekubuyiselweni kokufuna kwe-cocaine kumamodeli we-rodent wokubuyela emuva. Izikhombo ze-mPFC zibonakala zidlala izindima ezihlukile kulokhu kuziphatha, njengokuthi ihlombe le-prelimbic cortex (PL) lihambisane nokufuna i-cocaine kanti ne-infralimbic cortex (IL) kuhlongozwa ukucindezela ukufuna kwe-cocaine ngemuva kokuqothulwa. Le dichotomy yokusebenza kwe-mPFC ingaba uphawu olujwayelekile, njengoba umehluko ofanayo we-dorsal-ventral ukhona ekubonisweni vs. ukuqothulwa kwesimo sokwesaba. Kodwa-ke, eminye imiphumela ikhombisa ukuthi iqhaza lama-neuron we-mPFC ekusebenzeni kwemivuzo liyinkimbinkimbi kakhulu kune-PL-seek vs IL-extinguish dichotomy. Kokubili i-PL ne-IL kukhonjiswe ukushayela nokuvimbela ukufuna izidakamizwa (kanye nezinye izinhlobo zokuziphatha) ngokuya ngezinto ezahlukahlukene kufaka phakathi isimo sokuziphatha, umlando wezidakamizwa wesilwane, kanye nohlobo lomuthi ophenywayo. Lokhu kuhlangana kokutholakele kungakhombisa ama-subcircuits amaningi ngaphakathi kwalezi zindawo ze-PFC ezisekela imisebenzi ehlukile. Kungakhombisa neqiniso lokuthi i-mPFC idlala indima ebunjiwe ekubumbeni ukuqonda nokuziphatha, kufaka phakathi ukugcwala kokufuna nokuqothula i-cocaine. Lapha sixoxa ngocwaningo oluholela kumqondo ophansi wokuthi i-dorsal ne-ventral mPFC ilawula ngokwehlukana ukufuna izidakamizwa nokuqothulwa. Siphinde siveze imiphumela yakamuva ebiza uhlobo oluphelele lwe-dichotomy ye-PL vs IL Okokugcina, sibheka eminye imisebenzi ye-mPFC ehambelana kancane nokusebenza kokuphendula kanye nokuvinjwa futhi esikhundleni salokho kufaka nokuziphatha okuyinkimbinkimbi kokuziphatha okwazisa kakhulu i-mPFC.

Le ndatshana iyingxenye yengqungquthela ekhethekile ethi Izidakamizwa Zokulutha.