I-Psychopharmacology (i-Berl). 2015 Feb; 232 (4): 745-54. doi: 10.1007 / s00213-014-3709-9. I-Epub 2014 Aug 21.
IMurnane KS1, I-Gopinath KS, UMaltbie E, UDaunais JB, Telesford QK, I-Howell LL.
abstract
I-RATIONALE:
Umlutha we-Cocaine ubonakala ngokushintshana kwemijikelezo yokungabambi futhi ukubuyela emuva kanye nokulahlekelwa kokulawulwa kokusetshenziswa kwezidakamizwa naphezu kwemiphumela emibi kakhulu yempilo ehlobene nokuhlukunyezwa kwayo.
INJONGO:
Inhloso yalolu cwaningo olukhona bekuwukucacisa imibuthano ebaluleke kakhulu ye-neural ebandakanyeka ebungozini obukhona ekuqaliseni kokuzibusa kwe-cocaine ngemuva kokuhlala isikhathi eside.
IZINDLELA:
Lezi zifundo zaziyizinkawu ezintathu zabesifazane abahlaselwe ukuzilawula isikhathi eside kulandela umlando omude wokuzibusa nge-cocaine. Ukuhlolwa kokuqala kuhlolisise imiphumela yokulawulwa kwe-cocaine eyingozi (i-0.3 mg / kg, IV) ekuxhumaneni kobuchopho okusebenzayo kuwo wonke ubuchopho nakwezinethiwekhi ezithile zobuchopho ezihlobene nokulawulwa kokuziphatha kusetshenziswa ukucabanga kokusebenza kwengqondo kobuhlakani ezifundweni eziqonda ngokugcwele. Kamuva, lezi zifundo zavunyelwa ukuthi ziqale kabusha ukuzilawula kwe-cocaine ukunquma ukuthi ngabe ukulahleka kokuxhunyaniswa kwe-basal ngaphakathi kwamanethiwekhi athile obuchopho kubikezela ubukhulu bokuphinda kuqalile ukusebenzisa i-cocaine ngemuva kokuhlala isikhathi eside.
IZIPHUMA:
Ukuphathwa kwe-cocaine okwenzeka ngokuqinile kunciphise kakhulu ukuxhumeka kokusebenza komhlaba wonke nokukhetha ukungasebenzi kahle kwamasekhethi angaphambili alawula indlela yokuziphatha, ngenkathi isindisa ukuxhumana kwezindawo ezithintekayo ngaphakathi kwezijikelezo ezinamandla. Okubalulekile, ukuxhumana okungahambanga kahle phakathi kwezindawo zokuqala nezindawo ezigwinyayo ngesikhathi sokuvinjwa kwabikezela ukusetshenziswa kwe-cocaine lapho lezi zifundo zinikezwa ukufinyelela okuvuselelwa kwe-cocaine.
IMIBUZO:
Ngokusekelwe kulokhu okutholakele, ukulahleka kokuqala kokuxhumana kokusebenza kwesistimu kungenzeka kube yindlela ebucayi esekela umoya ongemuhle ongezansi wokujikeleza nokujikeleza okuphawula umlutha we-cocaine.
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