Am J Psychiatry. 2001 Dec;158(12):2015-21.
I-Volkow ND, Chang L, Wang GJ, UFowler JS, I-Ding YS, USedler M, Logan J, UFranceschi D, UGatley J, Hitzemann R, UGifford A, Wong C, UPappas N.
Umthombo
UMnyango Wezokwelapha, I-Brookhaven National Laborator, Upton, NY 11973, e-USA. [i-imeyili ivikelwe]
abstract
INJONGO:
Indima ye-dopamine kwinqubo yokulutha (ukulahleka kokulawula nokusebenzisa izidakamizwa okuphoqayo) ayiqondakali kahle. Ukutholwa okungaguquki kwezifundo eziluthwe izidakamizwa kuyizinga eliphansi lama-dopamine D2 receptors. Abahlukumezi be-cocaine, amazinga aphansi we-D2 receptors ahlotshaniswa nezinga eliphansi le-metabolism ku-orbitof Pambal cortex. Ngoba i-orbitof Pambal cortex ihlotshaniswa nokuziphatha okuphoqayo, ukuphazamiseka kwayo kungahle kube nomthelela ekutholeni izidakamizwa okuphoqayo ezifundweni eziluthayo. Lolu cwaningo luhlolisise ukuthi ngabe ukuhlangana okufana nalaba abahlukumezi be-methamphetamine.
INDLELA:
Abahlukumezi be-methamphetamine abayi-15 kanye nezifundo ze-20 ezingekho emthethweni zokusebenzisa kabi izidakamizwa bafundwa nge-positron emission tomography (PET) kanye ne- [11C] raclopride ukuze kuhlolwe ukutholakala kwe-dopamine D2 receptors kanye ne-[18F] fluorodeoxyglucose yokuhlola i-glucose metabolism yesigodi umsebenzi wobuchopho.
IZIPHUMA:
Abahlukumezi be-Methamphetamine babenezinga eliphansi kakhulu lokutholakala kwe-D2 receptor kunezifundo zokuqhathanisa (umehluko we-16% ku-caudate ne-10% ku-putamen). Ukutholakala kwe-receptor ye-D2 kuhlotshaniswa nesilinganiso se-metabolic ku-cortex ye-orbitofrontal kubahlukumezi nakwizifundo zokuqhathanisa.
IMIBUZO:
Izinga eliphansi lokutholakala kwe-dopamine D2 receptor liye labikwa ngaphambili kubahlukumezi be-cocaine, izidakwa, nabahlukumezi be-heroine. Lolu cwaningo luhambisa lokhu kuthola abahlukumezi be-methamphetamine. TUhlangana phakathi kwenqanaba le-dopamine D2 receptors kanye ne-metabolism ku-cortex ye-orbitofrontal abahlukumezayo, ephinda ithole okutholakele kwangaphambi kokuhlukumeza kwe-cocaine, uphakamisa ukuthi i-D2 receptor-Mediated dysregation ye-orbitofrontal cortex ingasebenza inqubo evamile yokulahleka kokusebenzisa izidakamizwa okuphoqayo ezifundweni eziluthwe izidakamizwa.
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