I-acrylic: Ukwehla kwe-frontal cortex dopamine (okwenzeka kumlutha), kuholele ekuphenduleni okukhulu kakhulu kwe-dopamine ekudleni nakulobulili. Okunye ukuthola ukuthi i-dopamine yangaphambili ye-cortex izovimbela umsebenzi wesekethe wokuvuza.
J Neurosci. I-1992 Sep; 12 (9): 3609-18.
I-PDF ephelele
UMitchell JB, uGratton A.
Umthombo
Isikhungo Sokucwaninga Esibhedlela saseDouglas, uMnyango Wezengqondo, iYunivesithi yaseMcGill, eMontreal, eQuebec, eCanada.
abstract
I-chronoamperometry enejubane eliphakeme yayisetshenziselwa ukuqapha ukuqina kwe-dopamine ngaphakathi kwe-nucleus accumbens, insimu yesifo se-mesolimbic dopamine system, ekuziphatheni kwamagundwane ngokukhululekile nsuku zonke, ezinsukwini ezilandelanayo ze-6, ukuya kwesinye sezisusa zombili zokugcizelela; Ukudla okuthandeka kakhulu noma izintambo ezihlobene nobulili.
Lezi zilwane kungenzeka ukuthi zazinjalo noma zazithole ama-microinjection we-6-hydroxydopamine ngaphambili kwi-cortex ye-lesion dopamine. Ukudla okunyuselwe ngokuthembekile kumazinga e-dopamine ngaphakathi kwe-nucleus accumbens, futhi uma i-dopamine yangaphambili ye-cortical dopamine ibingasasebenzi, impendulo yokudla ikhuphuka ngokuhlolwa okuphindaphindiwe. Izilwane ezivezwe ekuvuseleleni okuhlobene nezocansi zikhombise kancane kancane ukukhululwa kwe-dopamine ngokuhlolwa okuphindaphindekile, futhi lokhu kuthuthukiswa bekutholakala ngenxa yokudangala kokuqala kwe-cortical dopamine.
Le miphumela ikhombisa ukuthi ukuchayeka okuphindaphindiwe emicimbini yokuqinisa ngokwemvelo kungaholela ekuphikiseni uhlelo lwe-mesolimbic dopamine ekusebenzeni kwesikhathi esizayo, futhi siphakamise ukuthi ukuqagelwa kwe-dopamine ku-prefrontal cortex kunikeza ithonya le-neurotransication le-mesolimbic dopamine.
;