Ukucabangela kwamangqamuzana kubonisa ukuthi inyosi engapheliyo ukubhema ihlasela ingqondo yezobuchopho
Juni 6th, i-2011 ku-Neuroscience
Ubufakazi obucacile bomphumela omubi wokusetshenziswa kwensangu okungapheli okuvezwe eMhlanganweni Wonyaka Wama-58 weSNM kungaholela ekwelashweni kwezidakamizwa okungahle kwenzeke futhi kusize olunye ucwaningo oluthintekayo kuma-cannabinoid receptors, uhlelo lwe-neurotransmission oluthola ukunakwa okuningi. Ososayensi basebenzise ukucabanga kwamangqamuzana ukubona ngeso lengqondo izinguquko ebuchosheni bababhemi abasindayo bensangu uma kuqhathaniswa nabangabhemi futhi bathola ukuthi ukusetshenziswa kabi kwalesi sidakamizwa kuholele ekwehleni kwenani lama-receptor e-CB1 e-cannabinoid, angabandakanyeki nje ekuzijabuliseni, ekudleni nasekubekezeleleni izinhlungu kepha yeminye imisebenzi yengqondo nengokwenyama yomzimba.
"Izidakamizwa ziyinkinga enkulu kwezokwelapha nakwezomnotho," kusho uJussi Hirvonen, MD, PhD, umbhali oholayo wocwaningo oluhlanganyelwe phakathi kweNational Institute of Mental Health kanye neNational Institute on Drug Abuse, Bethesda, Md. "Ngeshwa, asikwazi ngokuphelele qonda izindlela ze-neurobiological ezibandakanyeka ekuluthweni. Ngalesi sifundo, sikwazile ukukhombisa okokuqala ukuthi abantu abahlukumeza i-cannabis banokungajwayelekile kwama-cannabinoid receptors ebuchosheni. Lolu lwazi lungahle lubonakale lubucayi ekwakhiweni kwezindlela ezintsha zokwelashwa kokuhlukunyezwa kwe-cannabis. Ngaphezu kwalokho, lolu cwaningo lubonisa ukuthi ukuncipha kwamamukeli kubantu abahlukumeza insangu kubuyela kokujwayelekile lapho beyeka ukubhema umuthi. ”
Ngokusho kweNational Institute on Drug Abuse, inambuzane iyinombolo-eyodwa yezidakamizwa ezingekho emthethweni e-America. I-chemicalactive chemic in the marijuana, noma i-cannabis, i-delta-i-9-tetrahydrocannabinol (THC), ehlangene nezinhlobonhlobo ze-receptors ezigcotshwa yi-cannabinoid ebuchosheni nasemzimbeni wonke lapho zibhema noma zilayishwa, zikhiqiza okuphezulu. I-receptors ye-cannabinoid ebuchosheni ithonya izinhlobonhlobo zezitshalo nezenzo zengqondo, kufaka phakathi injabulo, ukuhlushwa, ukubonwa kwesikhathi kanye nenkumbulo, ukuqonda komqondo, nokuhlanganiswa kokuhamba. Kukhona futhi ama-receptor e-cannabinoid kuwo wonke umzimba ohilelekile emisebenzini eminingi yokugaya, isifo senhliziyo, isifo sokuphefumula kanye nezinye izinhlelo zomzimba. Njengamanje ama-subtypes amabili e-receptors e-cannabinoid ayaziwa, i-CB1 ne-CB2, eyayivele iqhaza ikakhulukazi emisebenzini yesistimu ye-nervous central futhi ekugcineni emisebenzini yesistimu yesimiso semzimba kanye nasesimisweni se-stem yesistimu ye-circulatory.
Kulolu cwaningo, abacwaningi baqasha abashayeli be-cannabis abane-30 bansuku zonke ababe beqashwe esikhungweni sokugula esibhedlela esivaliwe cishe amasonto amane. Lezi zihloko zazitholakala nge-positron emission tomography (PET), enikeza ulwazi mayelana nezinqubo zomzimba emzimbeni. Izihloko zafakwa nge-radiligand, i-18F-FMPEP-d2, eyinhlanganisela ye-isotope ye-fluorine e-radioactive ne-analog ye-neurotransmitter ehambisana ne-CB1 yokuthola ubuchopho.
Imiphumela yocwaningo ibonisa ukuthi inombolo ye-receptor yanciphisa ngamaphesenti angu-20 ebuchosheni bokubhema komuthi we-cannabis uma kuqhathaniswa nezihloko zokulawula okunempilo ezinobungozi obunqunyiwe obunini be-cannabis ngesikhathi sokuphila kwabo. Lezi zinguquko zitholakale zinezixhumanisi nenombolo yezifundo zeminyaka. Ezingxenyeni zangempela ze-30 zomshukela, i-14 yezihloko zine-PET scan yesibili ngemva kwenyanga yokuziyeka. Kube nokunyuka okuphawulekayo komsebenzi we-receptor kulezo zindawo eziye zancipha ekuqaleni kwaleso sifundo, isibonakaliso sokuthi nakuba ukubhema okungenayo isifo sikashuna kubangela ukuhlukunyezwa kwe-receptors ye-CB1, umonakalo uphindaphindwa ngokuziyeka.
Ulwazi olutholakala kulezi zifundo nolwazi oluzayo lungasiza olunye ucwaningo oluhlola indima ye-PET imaging ye-receptors ye-CB1-hhayi nje ukusetshenziswa kwezidakamizwa, kodwa futhi nezifo zabantu, kuhlanganise nesifo somzimba kanye nomdlavuza.
Imininingwane engaphezulu: I-Scientific Paper 10: J. Hirvonen, R. Goodwin, C. Li1, G. Terry, S. Zoghbi, C Morse, V. Pike, N. Volkow, M. Huestis, R. Innis, National Institute of Mental Ezempilo, iBethesda, MD; Isikhungo Sikazwelonke Sokuhlukumeza Izidakamizwa, iBaltimore, MD; "Ukwehliswa kwemithetho yokubuyisela emuva nokukhetha esifundeni ama-CB1 receptors kuma-smokers abhema nsuku zonke," Umhlangano Wonyaka Wama-58 weSNM, ngoJuni 4-8, 2011, eSan Antonio, TX.
Kunikezwe iNhlangano Yezokwelapha Zenyukliya
;