IMIBUZO: I-Ecstasy esebenzisa amagundane ine-spike ku-dopamine futhi ithuthukisa lokho okubizwa ngokuthi indawo enesimo esikhethiwe- esikhetha ukuzihlalela lapho bathola khona umvuzo oqinile ngokungavamile. Amagundane nabantu abanezidakamizwa bahlangabezana nokuthandwa kwendawo enesimo. Eqinisweni, ukubuyela endaweni obukade usebenzisa kuyo izidakamizwa kuyimbangela enkulu yokubuyela emuva.
Kulolu cwaningo ukuzivocavoca kwe-aerobic (wheel run) kuqede i-dopamine spike evame ukubangelwa yi-Ecstasy, kanye nenketho yendawo enekhethelo. Ngokuyikho kwaqeda noma yiziphi izinkomba zomlutha. Ikwenzile ngaphandle kokuthinta kabi i-dopamine ne-dopamine receptors. Khumbula ukuthi yonke imilutha ibelana ngezindlela ezijwayelekile nezindlela zobuchopho, ikakhulukazi i-dopamine dysregulation. Ngakho-ke zivivinya umzimba.
I-Behav Brain Res. I-2008 Feb 11; 187 (1): 185-9. I-Epub 2007 Sep 16.
I-Chen HI, i-Kuo YM, uLiao CH, uJen CJ, uHuang AM, uCherng CG, uSu SW, uYu L.
UMnyango wePhysology, iNational Cheng Kung University College of Medicine, uTainan 701, eTaiwan, ROC.
abstract
Yize ukuvivinya umzimba kuye kwaziwa ukuthi kulawule ubuchopho be-brainity, umthelela wayo emvuzweni we-psychostimulant kanye nohlelo lwe-dolamine ehambisanayo ihlale icwaningwe. I-psychostimulant, i-3,4-methylenedioxymethamphetamine (MDMA), njengamanje umuthi wokuhlukumezeka osetshenziswa emhlabeni wonke. Sinqume ukubheka imiphumela yokushintsha kokuzivocavoca isikhathi eside, okuyimpoqo yokuqothula ngenani le-hedonic le-MDMA emgundwini weC57BL / 6J wesilisa.
I-MDMA ethonyelwe indawo enendawo yokukhangisa (CPP) isetshenziswe njengendlela yokuziphatha ekuboniseni ukusebenza kahle kwe-MDMA. Siphawule ukuthi amagundane okulawula ukuhlala kuwo wonke akhombisa i-CPP ethembeke kakhulu ye-MDMA nenqubo yethu yokubeka isimo. Kuyathakazelisa ukuthi ukubonwa ngaphambi kokuzivocavoca kwethayile kwehle i-CPP ebangelwe yi-MDMA ngendlela esezingeni elifanele. Ngokukhethekile, amagundane enza umsebenzi wokunyathela omatasa we-12-veki awakhombisanga ukusondelana okusondele kwigumbi elihlobene ne-MDMA kule paradigm ye-CPP.
Amaviki ayishumi nambili we-treadmill egijima awashintshanga umzimba we-MDMA 30min kulandela ukujova okukodwa kwe-MDMA (3mg / kg). Siphinde sasebenzisa inqubo ye-Microdialysis ukutadisha izindlela ezingaphansi zomvuzo we-MDMA ongalungile owenziwe yi-12-vhiki yokuzivocavoca ngaphambili. Sithole ukuthi ukukhishwa kwe-dopamine eyingozi kakhulu ye-MDMA okuvuselelekile kuma-nucleus accumbens kuchithwa kumagundane asetshenzisiwe, kanti ukuphakama okusobala kokukhishwa kwe-dopamine okuqaphelekayo kwaqapheleka kumagundane okulawula ukuhlala phansi.
Ekugcineni, uhlelo lokuzivocavoca lwe-12-sonto alushintshanga amazinga amaprotheni ama-dopamine receptors, ama-vesicular noma ama-membrane abathutha kule ndawo. Siphetha ngokuthi ukuvivinya isikhathi eside, okuphoqelelayo kuyasebenza ekunciphiseni ukusebenza kahle kwe-MDMA ngokunokwenzeka ngomthelela wayo oqondile ekubuyiselweni kokukhishwa kwe-dopamine ye-MDMA-evuswe ku-dopamine kuma-nucleus accumbens.
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