I-Inter Inter. 2010 Aug;10(4):219-30.
Umthombo
I-Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Mount School of Medicine, New York, NY, USA.
abstract
Umlutha wezidakamizwa uphawulwa izinguquko ezihlala njalo ekuziphatheni okuholela, ngokwengxenye, kusuka kumaphethini aguquliwe wesitatimende sofuzo ngaphakathi kwezifunda ze-limbic forebrain, njenge-nucleus accumbens (NAc). Lezi zinguquko ekubhalweni kwesakhi sofuzo zihlanganiswa ngochungechunge oluyinkimbinkimbi lokuguqulwa kwe-histone ezungeze iDNA okuholela ekuphindaphindweni noma ekuqalisweni kwesakhi sofuzo. Ubufakazi bamuva nje buveze inethiwekhi yezinguquko zezinhlobo zofuzo, ezilawulwa yi-transta factor DeltaFosB, eguqula ukwakheka nomsebenzi we-NAc medium spiny neurons ukulawula isimilo-somkhuba. Kulesi sibuyekezo, sizokhuluma ngenqubekela phambili yakamuva ekuqondeni kwethu umthetho we-chromatin yi-cocaine, kanye nemiphumela yalokho kulawulwa ku-plastiki ehlelekile kanye nokusebenza kwayo kokulutha kwezidakamizwa
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